Product image of Ketoprofene Biogaran (Ketoprofen) supplied by GNH India

Ketoprofene Biogaran

Active Ingredient:
Ketoprofen
Origin:
EU

Ketoprofene Biogaran (Ketoprofen)

Ketoprofen, the active ingredient in Ketoprofene Biogaran, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an oral tablet for oral use. It is employed to relieve inflammation and pain in musculoskeletal and rheumatic conditions.
GNH India supplies Ketoprofene Biogaran as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Biogaran

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Indications & Clinical Uses

Ketoprofen is an NSAID that reduces inflammation and pain in several musculoskeletal disorders.

  • Rheumatoid arthritis: decreases joint inflammation and pain, improving mobility.
  • Osteoarthritis: alleviates chronic joint pain and stiffness associated with cartilage degeneration.
  • Ankylosing spondylitis: reduces spinal inflammation and discomfort.
  • Acute musculoskeletal pain: provides rapid relief of pain from sprains, strains or injuries.
  • Post‑operative pain: helps control moderate pain following surgical procedures.

How It Works

  • Ketoprofen exerts its anti‑inflammatory and analgesic effects by reversibly inhibiting cyclooxygenase enzymes COX‑1 and COX‑2. This inhibition lowers the synthesis of prostaglandins, which are mediators of inflammation, pain, and fever, thereby reducing these symptoms at the site of tissue injury.

Side Effects

Ketoprofen may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Dyspepsia or stomach upset
  • Nausea or vomiting
  • Headache
  • Dizziness
  • Mild skin rash
  • Elevated liver enzymes

Serious or Rare Side Effects

  • Gastrointestinal bleeding or ulceration
  • Severe renal impairment
  • Hepatic failure
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis
  • Anaphylactic reactions
  • Cardiovascular thrombotic events

Precautions & Warnings

When prescribing or dispensing Ketoprofene Biogaran, consider the following safety measures.

  • Assess gastrointestinal risk: avoid in patients with a history of ulcers or GI bleeding.
  • Monitor renal function: use caution in patients with renal insufficiency.
  • Avoid in known hypersensitivity to ketoprofen or other NSAIDs.
  • Use caution with anticoagulants: increased bleeding risk.
  • Use caution in cardiovascular disease: may increase thrombotic risk.
  • Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Ketoprofen can interact with several drug classes, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): heightened bleeding risk.
  • Other NSAIDs or aspirin: additive gastrointestinal toxicity.
  • Corticosteroids: increased risk of ulceration.
  • Lithium: elevated lithium serum levels.
  • Methotrexate: reduced clearance, potential toxicity.

Moderate Interactions (Monitor Closely):\n- Diuretics: possible reduction in renal perfusion.

  • ACE inhibitors or ARBs: may impair renal function.
  • Beta‑blockers: potential for reduced antihypertensive effect.
  • Digoxin: altered plasma concentrations.
  • Cyclosporine: increased nephrotoxicity risk.

Frequently Asked Questions

Ketoprofene Biogaran contains ketoprofen, an NSAID indicated for the relief of inflammation and pain in rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, acute musculoskeletal injuries, and postoperative pain. It helps reduce swelling and improve joint function in these conditions.

Ketoprofen blocks the cyclooxygenase enzymes COX‑1 and COX‑2, which are essential for producing prostaglandins. By lowering prostaglandin levels, the drug diminishes the inflammatory response, reduces pain signals, and helps lower fever in affected tissues.

The appropriate dose of Ketoprofene Biogaran is determined by the prescribing healthcare professional based on the patient’s condition, age, renal and hepatic function, and other individual factors. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Ketoprofen is generally avoided during the third trimester of pregnancy because of potential fetal cardiovascular effects. It should be used only if clearly needed and prescribed by a qualified clinician. Limited data exist for breastfeeding; the drug may pass into milk, so a risk‑benefit assessment is required.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Ketoprofen shares the core COX‑inhibiting mechanism of other NSAIDs but has a relatively rapid onset of analgesia and a slightly higher potency for pain relief in musculoskeletal conditions. Its safety profile is similar, with comparable gastrointestinal and renal risks, though individual tolerability may vary.

Ketoprofene Biogaran should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in the original packaging, protect them from moisture and direct sunlight, and ensure the container is tightly closed to maintain product stability.

Ketoprofene Biogaran is supplied as oral tablets that are taken by mouth with a full glass of water. It may be taken with or without food, although taking it with meals can help reduce gastrointestinal discomfort.

Serious risks include gastrointestinal bleeding or ulceration, severe renal impairment, hepatic dysfunction, cardiovascular thrombotic events, and rare but life‑threatening skin reactions such as Stevens‑Johnson syndrome. Patients should be monitored for signs of these conditions, especially during long‑term therapy.

Ketoprofene Biogaran is contraindicated in individuals with known hypersensitivity to ketoprofen or any NSAID, those with active gastrointestinal ulceration or bleeding, severe renal or hepatic impairment, and patients in the third trimester of pregnancy. Caution is also advised for patients with uncontrolled hypertension or heart failure.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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