Product image of Ketoprofene Cristers (Ketoprofen) supplied by GNH India

Ketoprofene Cristers

Active Ingredient:
Ketoprofen
Origin:
EU

Ketoprofene Cristers (Ketoprofen)

Ketoprofen, the active ingredient in Ketoprofene Cristers, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an oral formulation for oral use. It is employed to relieve mild to moderate pain and to manage inflammatory conditions such as rheumatoid arthritis, osteoarthritis and other musculoskeletal disorders.

GNH India supplies Ketoprofene Cristers as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Cristers

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Indications & Clinical Uses

Ketoprofen belongs to the NSAID class and is used to treat pain and inflammation in several musculoskeletal disorders.

  • Rheumatoid arthritis: reduces joint inflammation and pain, improving mobility.
  • Osteoarthritis: alleviates chronic joint discomfort and swelling.
  • Musculoskeletal inflammatory conditions: diminishes inflammation in tendons, bursae and soft tissues.
  • Mild to moderate pain: provides analgesic relief for acute or chronic pain episodes.

How It Works

  • Ketoprofen exerts its effect by non‑selectively inhibiting cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes. This inhibition blocks the conversion of arachidonic acid to prostaglandins, thereby decreasing prostaglandin synthesis. Reduced prostaglandin levels lead to diminished inflammation, pain perception, and fever response in affected tissues.

Side Effects

Ketoprofen may cause a range of adverse reactions, from mild to severe. Patients should be aware of both common and serious possibilities.

Common Side Effects

  • Gastrointestinal upset: nausea, dyspepsia or abdominal discomfort.
  • Headache: mild to moderate intensity.
  • Dizziness or vertigo.
  • Skin rash or mild itching.

Serious or Rare Side Effects

  • Gastrointestinal ulceration or bleeding.
  • Acute renal impairment or worsening of chronic kidney disease.
  • Hepatic dysfunction, including elevated liver enzymes.
  • Severe skin reactions such as Stevens‑Johnson syndrome.
  • Anaphylactic or anaphylactoid reactions.
  • Cardiovascular events, including hypertension or thrombotic episodes.

Precautions & Warnings

Before initiating therapy with Ketoprofen, certain safety considerations should be observed.

  • Assess gastrointestinal risk: avoid use in patients with active ulcers or a history of GI bleeding.
  • Monitor renal function: caution in patients with existing kidney disease or dehydration.
  • Evaluate hepatic status: use carefully in those with liver impairment.
  • Review cardiovascular history: consider alternatives for patients with uncontrolled hypertension or prior thrombotic events.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, and protect from moisture.

Avoid Interactions

Ketoprofen can interact with several drug classes, altering efficacy or safety.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of serious bleeding.
  • Other NSAIDs or COX‑2 inhibitors: heightened gastrointestinal toxicity.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: may reduce antihypertensive effect and impair renal function.
  • Diuretics: potential for reduced renal perfusion.
  • Lithium: NSAIDs can raise lithium serum levels, requiring monitoring.

Frequently Asked Questions

Ketoprofene Cristers contains ketoprofen, an NSAID indicated for the relief of mild to moderate pain and for reducing inflammation in conditions such as rheumatoid arthritis, osteoarthritis and other musculoskeletal inflammatory disorders. It helps improve joint function and decrease discomfort associated with these diseases.

Ketoprofen works by non‑selectively blocking the cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which are essential for converting arachidonic acid into prostaglandins. By lowering prostaglandin production, the drug reduces the inflammatory response and the perception of pain at the site of injury or disease.

The appropriate dose of Ketoprofene Cristers is determined by the prescribing healthcare professional based on the individual’s medical condition, age, weight and response to therapy. Patients should follow the prescriber’s instructions and not adjust the dose without medical guidance.

Safety data for ketoprofen in pregnancy and lactation are limited. It is generally advised to avoid NSAIDs, including ketoprofen, during the third trimester of pregnancy and to discuss potential risks with a healthcare provider before use while pregnant or breastfeeding.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Ketoprofen shares a similar mechanism of action with other NSAIDs, providing analgesic and anti‑inflammatory effects. Compared with ibuprofen or naproxen, ketoprofen may have a slightly longer half‑life, allowing for less frequent dosing, but individual response and safety profiles vary, so choice should be individualized by the prescriber.

Ketoprofene Cristers should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability.

Ketoprofene Cristers is taken orally, usually with a full glass of water. It can be taken with or without food, although taking it with meals may reduce gastrointestinal discomfort. The exact administration schedule should follow the prescriber’s directions.

Serious risks include gastrointestinal bleeding or ulceration, severe renal impairment, hepatic injury, allergic reactions such as Stevens‑Johnson syndrome, and increased cardiovascular events. Patients should be monitored for signs of these conditions and seek immediate medical attention if they occur.

Ketoprofene Cristers should be avoided in individuals with known hypersensitivity to ketoprofen or other NSAIDs, active gastrointestinal ulcers, severe heart failure, uncontrolled hypertension, or significant renal or hepatic impairment. It is also contraindicated in patients taking anticoagulants where bleeding risk is a concern.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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