Product image of Ketoprofene Cristers Lp (Ketoprofen) supplied by GNH India

Ketoprofene Cristers Lp

Active Ingredient:
Ketoprofen
Origin:
EU

Ketoprofene Cristers Lp (Ketoprofen)

Ketoprofen, the active ingredient in Ketoprofene Cristers Lp, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an oral formulation for systemic use. It is employed to relieve mild to moderate pain and to manage inflammatory conditions such as rheumatoid arthritis, osteoarthritis and other musculoskeletal disorders.

GNH India supplies Ketoprofene Cristers Lp as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Cristers

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Indications & Clinical Uses

Ketoprofen is an NSAID that reduces inflammation and pain by inhibiting cyclooxygenase enzymes.

  • Rheumatoid arthritis: decreases joint pain, swelling and stiffness.
  • Osteoarthritis: alleviates chronic joint discomfort and improves mobility.
  • Musculoskeletal pain: provides relief from strains, sprains, back pain and other soft‑tissue injuries.

How It Works

  • Ketoprofen reversibly inhibits both cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, which blocks the conversion of arachidonic acid to prostaglandins. The reduced prostaglandin synthesis diminishes inflammation, pain signaling, and fever responses, producing its analgesic and anti‑inflammatory effects throughout the body.

Side Effects

Ketoprofen may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Gastrointestinal upset: dyspepsia, nausea or abdominal discomfort.
  • Headache: mild to moderate intensity.
  • Dizziness or vertigo.
  • Skin rash or pruritus.
  • Elevated liver enzymes.

Serious or Rare Side Effects

  • Gastrointestinal bleeding or ulcer perforation.
  • Acute renal impairment or failure.
  • Severe skin reactions such as Stevens‑Johnson syndrome.
  • Hepatic dysfunction or hepatitis.
  • Anaphylactic or severe allergic reactions.

Precautions & Warnings

When prescribing or dispensing Ketoprofene Cristers Lp, consider the following safety measures.

  • Assess renal function: avoid or adjust use in patients with significant renal impairment.
  • Monitor gastrointestinal health: contraindicated in active peptic ulcer disease or recent GI bleeding.
  • Avoid concomitant anticoagulants: increased risk of serious bleeding.
  • Use caution in cardiovascular disease: NSAIDs may elevate blood pressure and cardiovascular events.
  • Store at room temperature: keep in the original pack, protect from moisture and direct sunlight.

Avoid Interactions

Ketoprofen can interact with several drug classes, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): heightened bleeding risk.
  • Selective COX‑2 inhibitors (e.g., celecoxib): additive gastrointestinal and renal toxicity.
  • Lithium: increased serum lithium concentrations.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: may reduce renal function when combined.
  • Diuretics: potential for renal impairment and electrolyte disturbances.
  • Methotrexate: reduced clearance leading to toxicity.

Frequently Asked Questions

Ketoprofene Cristers Lp contains ketoprofen, an NSAID indicated for the relief of mild to moderate pain and for reducing inflammation in conditions such as rheumatoid arthritis, osteoarthritis and other musculoskeletal disorders.

Ketoprofen blocks the activity of cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which are essential for producing prostaglandins. By lowering prostaglandin levels, it diminishes the inflammatory response and the transmission of pain signals.

The appropriate dose of Ketoprofene Cristers Lp is determined by a qualified prescriber based on the patient’s condition, age, weight and overall health. Dosage instructions should always follow the healthcare professional’s recommendation.

Ketoprofen is generally not recommended during pregnancy, especially in the third trimester, because of potential risks to the fetus. It also passes into breast milk, so breastfeeding mothers should consult their physician before using this medication.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Ketoprofen shares the core mechanism of COX inhibition with other NSAIDs but is often noted for its relatively rapid onset of analgesia. Compared with ibuprofen or naproxen, it may provide stronger pain relief at comparable doses, though individual response and safety profiles can vary.

Ketoprofene Cristers Lp should be stored at room temperature, below 25 °C, in its original packaging. Protect the product from moisture, excessive heat and direct sunlight to maintain its stability.

The medication is taken orally, usually with a full glass of water. It can be taken with or without food, but taking it with food may reduce gastrointestinal discomfort for some patients.

Serious risks include gastrointestinal bleeding or ulcer perforation, severe renal impairment, liver injury, and rare but life‑threatening skin reactions such as Stevens‑Johnson syndrome or anaphylaxis. Patients should seek immediate medical attention if they experience symptoms like severe abdominal pain, blood in stool, sudden swelling or rash.

Individuals with a known hypersensitivity to ketoprofen or other NSAIDs, active peptic ulcer disease, severe heart failure, uncontrolled hypertension, or significant renal or hepatic impairment should avoid using this medication unless specifically directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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