Ketoprofene Eg (Ketoprofen)

Ketoprofen is used to manage pain and inflammatory conditions affecting the musculoskeletal system.

• Rheumatoid arthritis: reduces joint swelling, pain and stiffness.
• Osteoarthritis: alleviates chronic joint pain and improves mobility.
• Musculoskeletal disorders: eases pain from strains, sprains and overuse injuries.
• Acute pain: provides rapid relief of short‑term pain episodes.
• Post‑operative pain: helps control pain after surgical procedures.

• Ketoprofen inhibits cyclooxygenase (COX‑1 and COX‑2) enzymes, which blocks the conversion of arachidonic acid to prostaglandins. By reducing prostaglandin synthesis, it diminishes inflammation, pain signaling, and fever responses at the site of tissue injury.

Ketoprofen may cause a range of adverse reactions, from mild to severe.

Common Side Effects

• Gastrointestinal discomfort: nausea, dyspepsia or abdominal pain.
• Headache: mild to moderate intensity.
• Dizziness or vertigo.
• Skin reactions: rash or mild itching.
• Elevated liver enzymes: transient laboratory changes.

Serious or Rare Side Effects

• Gastrointestinal ulceration or bleeding.
• Severe hypersensitivity: anaphylaxis or Stevens‑Johnson syndrome.
• Renal impairment: acute kidney injury or reduced function.
• Cardiovascular events: increased risk of myocardial infarction or stroke.
• Hematologic abnormalities: thrombocytopenia or leukopenia.

When prescribing Ketoprofen, clinicians should consider patient‑specific risk factors and monitor for adverse events.

• Renal function: assess baseline kidney status and avoid in severe impairment.
• Gastrointestinal risk: use with caution in patients with a history of ulcers or bleeding.
• Cardiovascular health: avoid in individuals with uncontrolled hypertension or recent cardiac events.
• Concomitant medications: review for other NSAIDs, anticoagulants or corticosteroids.
• Pregnancy and lactation: use only if clearly needed after risk‑benefit evaluation.
• Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture and direct sunlight.

Ketoprofen can interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin): increased bleeding risk.
• Other NSAIDs or aspirin: heightened gastrointestinal toxicity.
• Corticosteroids: synergistic ulcerogenic effect.
• ACE inhibitors or ARBs: potential reduction in renal function.
• Lithium: elevated lithium serum levels.

Moderate Interactions (Monitor Closely):\n- Diuretics: possible decrease in renal perfusion.

• Methotrexate: reduced clearance leading to toxicity.
• Selective serotonin reuptake inhibitors (SSRIs): modest increase in bleeding risk.
• Oral hypoglycemics: may affect blood glucose control.
• Antihypertensives: potential attenuation of blood pressure‑lowering effect.