Ketoprofene Eg Stada (Ketoprofen)

Ketoprofen is an NSAID that reduces inflammation and pain in several musculoskeletal disorders.

• Mild to moderate pain: Provides analgesic relief by decreasing local prostaglandin production.
• Osteoarthritis: Helps improve joint function and reduces swelling associated with degenerative joint disease.
• Rheumatoid arthritis: Alleviates inflammatory symptoms and joint tenderness in autoimmune arthritis.
• Acute musculoskeletal injuries: Diminishes pain and edema following strains, sprains, or overuse injuries.
• Post‑operative inflammation: Assists in controlling localized inflammation after minor surgical procedures.

• Ketoprofen reversibly inhibits cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, blocking the conversion of arachidonic acid to prostaglandins. By lowering prostaglandin levels at the site of application, it reduces inflammation, pain signaling, and fever responses associated with musculoskeletal and joint disorders.

Ketoprofen may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

• Skin irritation or erythema at the application site.
• Pruritus or mild itching.
• Dryness or peeling of the treated skin.
• Localized burning sensation.
• Mild headache.

Serious or Rare Side Effects

• Severe allergic reaction (e.g., angio‑edema, anaphylaxis).
• Stevens‑Johnson syndrome or toxic epidermal necrolysis.
• Systemic NSAID‑related gastrointestinal bleeding.
• Renal impairment with prolonged use.
• Hepatotoxicity manifested by abnormal liver enzymes.

Before using Ketoprofene Eg Stada, consider the following safety measures.

• Allergies: Avoid if you have known hypersensitivity to ketoprofen or other NSAIDs.
• Skin conditions: Do not apply on broken, infected, or severely inflamed skin.
• Pregnancy: Use only if clearly prescribed; safety data are limited.
• Renal or hepatic disease: Consult a healthcare professional before use.
• Concomitant NSAIDs: Limit use with other systemic NSAIDs to reduce risk of adverse effects.
• Store at room temperature: Keep below 25°C in the original packaging, protected from moisture and direct sunlight.

Ketoprofen can interact with several drug classes, influencing efficacy or safety.

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin): Increased risk of bleeding.
• Other NSAIDs or COX‑2 inhibitors: Heightened gastrointestinal and renal toxicity.
• Corticosteroids: Elevated chance of ulceration and bleeding.

Moderate Interactions (Monitor Closely)

• ACE inhibitors or ARBs: May reduce renal function, especially in dehydrated patients.
• Diuretics: Potential for decreased renal perfusion.
• Lithium: NSAIDs can raise lithium serum levels, requiring monitoring.