Product image of Ketoprofene Lp Arrow (Ketoprofen) supplied by GNH India

Ketoprofene Lp Arrow

Active Ingredient:
Ketoprofen
Origin:
EU

Ketoprofene Lp Arrow (Ketoprofen)

Ketoprofen, the active ingredient in Ketoprofene Lp Arrow, is a nonsteroidal anti‑inflammatory drug (NSAID) presented as an oral tablet for oral use. It is employed to relieve mild to moderate pain and to reduce inflammation associated with conditions such as rheumatoid arthritis, osteoarthritis and other musculoskeletal disorders, primarily in adult patients. The drug works by inhibiting cyclooxygenase enzymes, which lowers prostaglandin production and thereby diminishes the inflammatory response. It is formulated for systemic absorption after swallowing and is intended for short‑term management under medical supervision.

GNH India supplies Ketoprofene Lp Arrow as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Arrow Generiques

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Indications & Clinical Uses

Ketoprofen is indicated for inflammatory and pain‑related conditions that involve the cyclooxygenase pathway.

  • Rheumatoid arthritis: reduces joint inflammation and pain, improving mobility.
  • Osteoarthritis: alleviates chronic joint discomfort and swelling.
  • Musculoskeletal pain: provides analgesic relief for strains, sprains and back pain.
  • Mild to moderate acute pain: manages postoperative or injury‑related pain where NSAID therapy is appropriate.

How It Works

  • Ketoprofen exerts its anti‑inflammatory and analgesic actions by non‑selectively inhibiting the cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes. This blockade reduces the conversion of arachidonic acid to prostaglandins and thromboxanes, mediators that promote inflammation, pain, and fever. By lowering prostaglandin levels at sites of tissue injury, ketoprofen diminishes vascular permeability, edema and sensitization of nociceptors, resulting in symptom relief.

Side Effects

Ketoprofen may cause a range of adverse reactions, which are generally categorized by frequency and severity.

Common Side Effects

  • Gastrointestinal discomfort: nausea, dyspepsia or abdominal pain.
  • Headache: mild to moderate intensity.
  • Dizziness or vertigo.
  • Skin rash or pruritus.
  • Diarrhea: loose stools occasionally.
  • Peripheral edema: mild swelling of lower limbs.

Serious or Rare Side Effects

  • Peptic ulcer disease or gastrointestinal bleeding.
  • Severe hepatic injury or markedly elevated liver enzymes.
  • Renal impairment or acute kidney injury.
  • Anaphylactic or severe hypersensitivity reactions.
  • Myocardial infarction or other thrombotic cardiovascular events.

Precautions & Warnings

When prescribing or dispensing ketoprofen, several safety considerations should be observed to minimize risk.

  • Assess gastrointestinal risk: avoid in patients with active ulcers or a history of GI bleeding.
  • Evaluate renal function: use caution in those with impaired kidney function or dehydration.
  • Monitor hepatic status: avoid in severe liver disease and check liver enzymes periodically.
  • Cardiovascular caution: consider risk of thrombotic events in patients with established heart disease.
  • Concomitant drug review: avoid concurrent use with other NSAIDs, anticoagulants or corticosteroids without supervision.
  • Store at ambient temperature: keep below 25 °C in the original packaging, protected from moisture and light.

Avoid Interactions

Ketoprofen can interact with several medicines, altering efficacy or increasing toxicity.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): heightened bleeding risk.
  • Other NSAIDs or COX‑2 inhibitors: additive gastrointestinal toxicity.
  • SSRIs or SNRIs: increased chance of GI bleeding.

Moderate Interactions (Monitor Closely)

  • Lithium: NSAIDs can raise lithium serum levels.
  • Methotrexate: reduced clearance leading to toxicity.
  • Corticosteroids: enhanced risk of ulceration.

Frequently Asked Questions

Ketoprofene Lp Arrow contains ketoprofen, an NSAID indicated for the relief of mild to moderate pain and for reducing inflammation in conditions such as rheumatoid arthritis, osteoarthritis and other musculoskeletal disorders. It is prescribed when a short‑term anti‑inflammatory and analgesic effect is required.

Ketoprofen works by non‑selectively inhibiting the cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which blocks the conversion of arachidonic acid to prostaglandins and thromboxanes. The resulting decrease in prostaglandin levels reduces inflammation, pain, and fever at the site of tissue injury.

The specific dose of Ketoprofene Lp Arrow is determined by the prescribing clinician based on the individual’s condition, severity of symptoms, age, renal and hepatic function, and other concurrent medications. Healthcare professionals follow local prescribing guidelines to select an appropriate regimen.

Safety data for ketoprofen in pregnancy and lactation are limited, and the drug is generally avoided unless the potential benefit outweighs the risk. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternative therapies with their healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity of Ketoprofene Lp Arrow. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Both ketoprofen and ibuprofen belong to the NSAID class and share a similar mechanism of COX inhibition. Ketoprofen is often considered slightly more potent on a milligram‑per‑milligram basis, but it may also carry a higher risk of gastrointestinal irritation. Choice between them depends on clinical response, tolerability and physician preference.

Ketoprofene Lp Arrow tablets should be stored at ambient temperature, preferably below 25 °C. Keep them in the original blister or container, protect from moisture, heat and direct sunlight, and keep out of reach of children.

The product is taken orally, usually with a full glass of water. It may be taken with food or after meals to lessen possible stomach upset, unless the prescriber advises otherwise. Swallow the tablet whole; do not crush or chew unless instructed.

Serious adverse events include gastrointestinal bleeding or ulceration, severe liver injury, acute kidney impairment, anaphylactic reactions, and cardiovascular events such as myocardial infarction or stroke. Patients should seek immediate medical attention if they experience symptoms like black stools, severe abdominal pain, jaundice, sudden swelling, or difficulty breathing.

Ketoprofene Lp Arrow should be avoided in individuals with known hypersensitivity to ketoprofen or other NSAIDs, active peptic ulcer disease, severe heart failure, uncontrolled hypertension, significant renal or hepatic impairment, and in patients taking anticoagulants without close monitoring. Pregnant women in the third trimester and breastfeeding mothers should also refrain unless directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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