Product image of Ketoprofene Lp Cristers (Ketoprofen) supplied by GNH India

Ketoprofene Lp Cristers

Active Ingredient:
Ketoprofen
Origin:
EU

Ketoprofene Lp Cristers (Ketoprofen)

Ketoprofen, the active ingredient in Ketoprofene Lp Cristers, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an oral dosage form for oral use. It is used to relieve mild to moderate pain and to reduce inflammation in conditions such as rheumatoid arthritis, osteoarthritis and musculoskeletal disorders.

GNH India supplies Ketoprofene Lp Cristers as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation for global distribution, sourcing from EU‑approved manufacturers that meet European pharmacopoeia specifications.

Manufacturer / TM Owner

Cristers

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Indications & Clinical Uses

  • Ketoprofen is indicated for inflammatory and pain‑related conditions affecting the musculoskeletal system.
  • Mild to moderate pain: provides analgesic relief for acute or chronic pain.
  • Rheumatoid arthritis: reduces joint inflammation and improves mobility.
  • Osteoarthritis: alleviates joint pain and stiffness associated with degenerative changes.
  • Musculoskeletal injuries: diminishes inflammation and facilitates functional recovery.

How It Works

  • Ketoprofen exerts its effect by non‑selectively inhibiting cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, which blocks the conversion of arachidonic acid to prostaglandins. The reduction in prostaglandin synthesis diminishes peripheral sensitisation of nociceptors and lowers inflammatory mediators, resulting in analgesic, antipyretic and anti‑inflammatory actions throughout the body.

Side Effects

Ketoprofen may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Gastrointestinal upset: nausea, dyspepsia or abdominal discomfort.
  • Headache: mild to moderate intensity.
  • Dizziness or vertigo.
  • Skin rash or pruritus.

Serious or Rare Side Effects

  • Gastrointestinal ulceration or bleeding.
  • Renal impairment or acute kidney injury.
  • Severe hypersensitivity reactions such as Stevens‑Johnson syndrome.
  • Cardiovascular events like myocardial infarction or stroke.

Precautions & Warnings

When prescribing ketoprofen, clinicians should consider several safety precautions to minimise risk.

  • Assess renal function: evaluate kidney status before initiating therapy and monitor periodically.
  • Monitor gastrointestinal risk: avoid use in patients with a history of peptic ulcer disease or bleeding.
  • Check for NSAID hypersensitivity: discontinue if allergic reactions occur.
  • Use cautiously in cardiovascular disease: consider increased risk of thrombotic events.
  • Store at ambient temperature below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Ketoprofen can interact with other medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of bleeding.
  • Other NSAIDs or aspirin: additive gastrointestinal toxicity.
  • Systemic corticosteroids: heightened chance of ulceration or bleeding.

Moderate Interactions (Monitor Closely)

  • Diuretics: may reduce renal clearance of ketoprofen.
  • Methotrexate: potential for increased toxicity.
  • Selective serotonin reuptake inhibitors (SSRIs): elevated bleeding risk.

Frequently Asked Questions

Ketoprofene Lp Cristers contains ketoprofen, an NSAID that is used to relieve mild to moderate pain and to reduce inflammation in conditions such as rheumatoid arthritis, osteoarthritis and other musculoskeletal disorders.

Ketoprofen works by non‑selectively inhibiting the cyclooxygenase enzymes COX‑1 and COX‑2, which reduces the synthesis of prostaglandins. Lower prostaglandin levels decrease inflammation, pain signalling and fever, providing analgesic and anti‑inflammatory effects.

The appropriate dose of Ketoprofene Lp Cristers is determined by the prescribing healthcare professional based on the patient’s condition, age, renal and hepatic function, and other individual factors. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data for ketoprofen in pregnancy and lactation are limited. It is generally advised to avoid NSAIDs, including ketoprofen, during the third trimester and to discuss any use during pregnancy or breastfeeding with a qualified healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Both ketoprofen and ibuprofen belong to the NSAID class and share similar mechanisms of COX inhibition. Ketoprofen is often considered slightly more potent on a milligram‑per‑milligram basis, but individual response, tolerability and safety profile may differ, so the choice depends on clinical judgment and patient factors.

Store Ketoprofene Lp Cristers at ambient temperature below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability.

Ketoprofene Lp Cristers is intended for oral administration. The tablet or capsule should be swallowed whole with a full glass of water, preferably with food or milk to reduce gastrointestinal irritation, unless otherwise directed by a healthcare professional.

Serious risks include gastrointestinal ulceration or bleeding, renal impairment, severe hypersensitivity reactions such as Stevens‑Johnson syndrome, and cardiovascular events like myocardial infarction or stroke. Patients should be educated to seek immediate medical attention if they experience signs of these conditions.

Ketoprofene Lp Cristers should be avoided in individuals with known hypersensitivity to ketoprofen or other NSAIDs, active gastrointestinal ulcer or bleeding, severe renal or hepatic impairment, and in patients with established high cardiovascular risk unless specifically advised by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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