Product image of Ketoprofene Lp Zentiva (Ketoprofen) supplied by GNH India

Ketoprofene Lp Zentiva

Active Ingredient:
Ketoprofen
Origin:
EU

Ketoprofene Lp Zentiva (Ketoprofen)

Ketoprofen, the active ingredient in Ketoprofene Lp Zentiva, is a nonsteroidal anti-inflammatory drug presented as an oral dosage form for systemic use. It treats mild to moderate pain and inflammatory conditions such as rheumatoid arthritis, osteoarthritis, and musculoskeletal pain in adults.

GNH India supplies Ketoprofene Lp Zentiva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Zentiva France

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Indications & Clinical Uses

  • Ketoprofen is used to manage pain and inflammation associated with several musculoskeletal and rheumatic disorders.
  • Rheumatoid arthritis: reduces joint inflammation and pain, improving mobility.
  • Osteoarthritis: alleviates chronic joint pain and stiffness.
  • Musculoskeletal pain: provides relief from acute injuries, sprains, and strains.

How It Works

  • Ketoprofen exerts its effect by non‑selectively inhibiting cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which blocks the conversion of arachidonic acid to prostaglandins. The resulting decrease in prostaglandin synthesis reduces inflammation, pain, and fever at the site of tissue injury.

Side Effects

Ketoprofen may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Gastrointestinal discomfort or dyspepsia
  • Nausea or vomiting
  • Headache
  • Dizziness
  • Mild skin rash
  • Elevated blood pressure

Serious or Rare Side Effects

  • Gastrointestinal ulceration or bleeding
  • Severe allergic reactions such as anaphylaxis or Stevens‑Johnson syndrome
  • Hepatic injury or elevated liver enzymes
  • Renal impairment or acute kidney injury
  • Cardiovascular events such as myocardial infarction or stroke

Precautions & Warnings

  • Before initiating therapy, clinicians should consider several safety aspects.
  • Assess gastrointestinal risk: evaluate history of ulcers or bleeding before use.
  • Monitor renal function: avoid in patients with severe kidney impairment.
  • Check cardiovascular status: use cautiously in those with heart disease.
  • Avoid concomitant use with other NSAIDs or anticoagulants unless necessary.
  • Pregnancy and lactation: use only if benefits outweigh risks.
  • Store at ambient temperature: keep in original packaging, protect from moisture and heat.

Avoid Interactions

Ketoprofen can interact with several drug classes, requiring attention to avoid harmful effects.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased bleeding risk.
  • Other NSAIDs or COX‑2 inhibitors: additive gastrointestinal toxicity.
  • Selective serotonin reuptake inhibitors (SSRIs): heightened bleeding risk.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: may reduce renal function.
  • Lithium: NSAIDs can increase lithium levels.
  • Diuretics (e.g., thiazides): may impair renal clearance.

Frequently Asked Questions

Ketoprofene Lp Zentiva contains ketoprofen, an NSAID indicated for the relief of mild to moderate pain and for reducing inflammation in conditions such as rheumatoid arthritis, osteoarthritis, and acute musculoskeletal injuries.

Ketoprofen blocks both COX‑1 and COX‑2 enzymes, preventing the formation of prostaglandins that mediate inflammation, pain, and fever. By lowering prostaglandin levels, it diminishes the inflammatory response and provides analgesia.

The appropriate dose of ketoprofen is determined by the prescribing clinician based on the patient’s condition, age, renal and hepatic function, and other individual factors. Patients should follow the dosage instructions provided by their healthcare professional.

Ketoprofen is generally avoided during pregnancy, especially in the third trimester, because of potential risks to the fetus and complications during labor. Use while breastfeeding is also discouraged unless the benefit outweighs the risk, and only under medical supervision.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Ketoprofen is similar to other NSAIDs such as ibuprofen and naproxen in its mechanism of COX inhibition, but it often provides a slightly longer duration of analgesia. Its safety profile is comparable, though individual tolerance and specific organ risk factors may influence the choice of agent.

Store the product at ambient temperature, preferably below 25 °C. Keep it in the original container, protect it from moisture, direct sunlight and excessive heat to maintain stability and potency.

Ketoprofene Lp Zentiva is taken orally, usually with a full glass of water. It may be taken with or without food, but taking it with meals can help reduce gastrointestinal discomfort.

Serious risks include gastrointestinal ulceration or bleeding, severe allergic reactions such as anaphylaxis or Stevens‑Johnson syndrome, liver injury, kidney impairment, and increased risk of cardiovascular events like heart attack or stroke. Patients should seek immediate medical attention if they notice any of these signs.

Ketoprofen should be avoided in individuals with a known hypersensitivity to ketoprofen or other NSAIDs, active gastrointestinal ulcer or bleeding, severe renal or hepatic impairment, uncontrolled hypertension, and in the third trimester of pregnancy. Consultation with a healthcare provider is essential before starting therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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