Product image of Ketoprofene Medisol (Ketoprofen) supplied by GNH India

Ketoprofene Medisol

Active Ingredient:
Ketoprofen
Origin:
EU

Ketoprofene Medisol (Ketoprofen)

Ketoprofen, the active ingredient in Ketoprofene Medisol, is a Nonsteroidal anti-inflammatory drug (NSAID) presented as an intravenous solution for intravenous use. It treats pain and inflammation, including postoperative pain and musculoskeletal disorders, in adult patients. It is indicated for the management of acute pain, postoperative discomfort, and inflammatory musculoskeletal conditions, offering rapid analgesic and anti‑inflammatory effects when administered intravenously.

GNH India supplies Ketoprofene Medisol as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide. The company ensures quality compliance with EU standards and provides reliable logistics for global healthcare facilities.

Manufacturer / TM Owner

Medisol

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Indications & Clinical Uses

Ketoprofen is an NSAID that reduces inflammation and pain by inhibiting cyclooxygenase enzymes.

  • Pain: provides analgesic relief in acute pain conditions.
  • Postoperative pain: reduces discomfort following surgical procedures.
  • Musculoskeletal disorders: alleviates inflammation in conditions such as osteoarthritis and rheumatoid arthritis.
  • Inflammation: controls systemic inflammatory responses in various clinical settings.

How It Works

  • Ketoprofen exerts its therapeutic effect through reversible inhibition of cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes. By blocking these enzymes, it decreases the synthesis of prostaglandins, which are mediators of inflammation, pain, and fever. The reduction in prostaglandin levels leads to diminished inflammatory response, analgesia, and antipyretic activity. The inhibition is dose‑dependent and reversible, allowing normal prostaglandin production to resume after the drug is cleared, which contributes to its safety profile compared with irreversible COX inhibitors.

Side Effects

Ketoprofen may be associated with a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Gastrointestinal discomfort: nausea, dyspepsia, or abdominal pain.
  • Headache: mild to moderate intensity.
  • Dizziness or vertigo.
  • Injection site reactions: erythema, pain, or swelling.

Serious or Rare Side Effects

  • Gastrointestinal bleeding or ulcer perforation.
  • Severe skin reactions such as Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Anaphylactic or severe hypersensitivity reactions.
  • Renal impairment or acute kidney injury.

Precautions & Warnings

When using Ketoprofene Medisol, clinicians should observe several precautionary measures to minimize risk.

  • Assess renal function: monitor serum creatinine and urine output before and during therapy.
  • Evaluate hepatic function: check liver enzymes periodically.
  • Use caution in cardiovascular disease: NSAIDs may increase risk of thrombotic events.
  • Avoid in patients with known hypersensitivity to ketoprofen or other NSAIDs.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Ketoprofen can interact with other medicines, influencing efficacy or safety.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of bleeding.
  • Other NSAIDs or COX‑2 inhibitors: additive gastrointestinal toxicity.
  • ACE inhibitors or ARBs: heightened risk of renal impairment.

Moderate Interactions (Monitor Closely)

  • Diuretics: possible reduction in diuretic effect and renal function.
  • Lithium: ketoprofen may raise lithium serum concentrations.
  • Methotrexate: reduced clearance leading to toxicity.
  • SSRIs or SNRIs: enhanced bleeding tendency.

Frequently Asked Questions

Ketoprofene Medisol is an intravenous formulation of ketoprofen, an NSAID indicated for the treatment of acute pain, postoperative pain and inflammatory musculoskeletal disorders. It provides rapid analgesic and anti‑inflammatory effects when administered by a healthcare professional.

Ketoprofen works by reversibly inhibiting the cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which reduces the synthesis of prostaglandins. Lower prostaglandin levels diminish inflammation, pain signalling and fever, producing the drug’s analgesic, anti‑inflammatory and antipyretic actions.

The appropriate dose of Ketoprofene Medisol is determined by the prescribing clinician based on the patient’s condition, severity of pain, weight, renal and hepatic function, and any concomitant therapies. Dosing regimens are individualized and should follow the prescriber’s instructions.

Safety data for ketoprofen in pregnancy and lactation are limited, and the product is classified as having an unknown pregnancy category. It is generally avoided unless the potential benefit outweighs the risk, and breastfeeding mothers should consult their healthcare provider before use.

To order Ketoprofene Medisol, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and any necessary import documentation.

Ketoprofene Medisol belongs to the same class of non‑steroidal anti‑inflammatory drugs as ibuprofen, diclofenac and naproxen. Compared with some oral NSAIDs, the intravenous route offers faster onset of action and more predictable plasma levels, which can be advantageous in acute postoperative settings.

Ketoprofene Medisol should be stored at 2‑8 °C in a refrigerator, protected from light. The solution must not be frozen or shaken vigorously. If temperature excursions occur, the product should be inspected for clarity and used only if it remains within specifications.

Ketoprofene Medisol is administered intravenously by a qualified healthcare professional. The prescriber determines the infusion rate and total dose, which is typically delivered over a short period to achieve rapid analgesia. Administration should follow aseptic technique and institutional infusion guidelines.

Serious risks include gastrointestinal bleeding or ulcer perforation, severe skin reactions such as Stevens‑Johnson syndrome, anaphylaxis, and acute renal failure. Patients should be monitored for signs of bleeding, rash, respiratory distress or sudden changes in kidney function during therapy.

Ketoprofene Medisol is contraindicated in patients with known hypersensitivity to ketoprofen or any NSAID, active gastrointestinal ulcer or bleeding, severe renal or hepatic impairment, and in those with a history of severe cardiovascular events unless specifically directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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