Ketoprofene Sale Di Lisina Coop (Ketoprofen Lysine)

Ketoprofen is an NSAID that reduces inflammation and pain in several musculoskeletal and rheumatic conditions.

• Rheumatoid arthritis: decreases joint inflammation and relieves pain, improving functional ability.
• Osteoarthritis: alleviates chronic joint discomfort and stiffness, supporting mobility.
• Musculoskeletal pain: provides relief from acute strain, sprain or injury‑related pain.
• Ankylosing spondylitis: reduces spinal inflammation and associated pain.
• Acute gout flares: lessens inflammatory pain and swelling.

• Ketoprofen exerts its anti‑inflammatory and analgesic actions by reversibly inhibiting the cyclooxygenase enzymes COX‑1 and COX‑2. This inhibition blocks the conversion of arachidonic acid to prostaglandins, thereby decreasing prostaglandin synthesis at sites of inflammation. The reduced prostaglandin levels diminish vascular permeability, pain‑sensitising signals and leukocyte infiltration, resulting in lowered inflammation and pain perception. The effect is dose‑dependent and contributes to the clinical relief of pain and swelling.

Ketoprofen may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

• Gastrointestinal discomfort: nausea, dyspepsia or abdominal pain.
• Headache: mild to moderate intensity.
• Dizziness or vertigo.
• Skin rash or pruritus.
• Elevated liver enzymes (asymptomatic).

Serious or Rare Side Effects

• Gastrointestinal ulceration or bleeding.
• Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.
• Hepatotoxicity: clinically significant liver injury.
• Renal impairment: acute kidney injury or worsening chronic kidney disease.
• Anaphylactic reaction: severe hypersensitivity requiring emergency care.
• Cardiovascular events: increased risk of myocardial infarction or stroke.

When prescribing ketoprofen, clinicians should evaluate patient risk factors and monitor for potential complications.

• Assess renal function: adjust use in patients with impaired kidney function.
• Monitor hepatic status: avoid in severe liver disease or elevated transaminases.
• Avoid in active peptic ulcer disease: heightened risk of gastrointestinal bleeding.
• Use cautiously in elderly: increased susceptibility to adverse effects.
• Store at ambient temperature: keep in the original pack, protect from moisture.

Ketoprofen can interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin): increased risk of serious bleeding.
• Selective serotonin reuptake inhibitors (SSRIs): heightened gastrointestinal bleeding potential.
• Lithium: ketoprofen may raise lithium plasma concentrations.

Moderate Interactions (Monitor Closely)

• ACE inhibitors or ARBs: possible reduction in renal function when combined.
• Diuretics: may exacerbate renal impairment and electrolyte disturbances.
• Methotrexate: decreased clearance leading to toxicity.