Product image of Ketoprofene Sale Di Lisina Pensa (Ketoprofen Lysine) supplied by GNH India

Ketoprofene Sale Di Lisina Pensa

Active Ingredient:
Ketoprofen Lysine
Origin:
EU

Ketoprofene Sale Di Lisina Pensa (Ketoprofen Lysine)

Ketoprofen lysine, the active ingredient in Ketoprofene Lisina Pensa, is a nonsteroidal anti‑inflammatory drug presented as an oral dosage form for oral use. It is employed to relieve mild to moderate pain and to reduce inflammation in conditions such as osteoarthritis and rheumatoid arthritis.

GNH India supplies Ketoprofene Lisina Pensa as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable global distribution.

Manufacturer / TM Owner

Towa Pharmaceutical S.P.A.

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Indications & Clinical Uses

Ketoprofen lysine is indicated for pain and inflammatory disorders affecting the musculoskeletal system.

  • Osteoarthritis: reduces joint pain and improves mobility.
  • Rheumatoid arthritis: alleviates inflammatory joint pain and swelling.
  • Acute musculoskeletal pain: provides analgesia for sprains, strains, and back pain.
  • Post‑operative pain: helps manage mild to moderate pain after surgical procedures.

How It Works

  • Ketoprofen lysine exerts its effect by reversibly inhibiting cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which blocks the conversion of arachidonic acid to prostaglandins. The reduction in prostaglandin synthesis diminishes peripheral sensitisation of nociceptors and decreases inflammatory mediators, resulting in analgesic, antipyretic and anti‑inflammatory actions.

Side Effects

Ketoprofen lysine may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Gastrointestinal discomfort (indigestion, abdominal pain)
  • Nausea
  • Dyspepsia
  • Headache
  • Dizziness
  • Skin rash

Serious or Rare Side Effects

  • Gastrointestinal ulceration or bleeding
  • Severe skin reactions such as Stevens‑Johnson syndrome
  • Renal impairment or failure
  • Hepatic dysfunction
  • Anaphylactic or severe allergic reactions
  • Elevated blood pressure or cardiovascular events

Precautions & Warnings

When prescribing or dispensing ketoprofen lysine, consider the following precautions to minimise risk.

  • Assess renal function: evaluate baseline kidney function, especially in elderly or dehydrated patients.
  • Monitor hepatic function: check liver enzymes periodically in patients with existing liver disease.
  • Use lowest effective dose: limit duration and dose to the minimum needed for symptom control.
  • Avoid in known NSAID hypersensitivity: discontinue if allergic reactions occur.
  • Caution in cardiovascular disease: assess risk as NSAIDs may increase thrombotic events.
  • Store at room temperature: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Ketoprofen lysine can interact with several medicines; awareness of major and moderate interactions helps ensure safe use.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of bleeding.
  • Concomitant NSAIDs or aspirin: additive gastrointestinal toxicity.
  • ACE inhibitors or ARBs: may reduce renal perfusion and function.

Moderate Interactions (Monitor Closely)

  • Selective serotonin reuptake inhibitors (SSRIs): heightened bleeding tendency.
  • Diuretics: potential for reduced renal clearance.
  • Lithium: risk of elevated lithium serum levels.

Frequently Asked Questions

Ketoprofene Lisina Pensa, containing ketoprofen lysine, is used to treat mild to moderate pain and inflammation associated with osteoarthritis, rheumatoid arthritis, acute musculoskeletal injuries, and post‑operative discomfort. It belongs to the NSAID class and helps reduce swelling and improve mobility in these conditions.

Ketoprofen lysine works by reversibly inhibiting the cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which are essential for prostaglandin production. By lowering prostaglandin levels, it reduces peripheral sensitisation of pain receptors and diminishes inflammatory mediators, providing analgesic and anti‑inflammatory effects.

The appropriate dose of Ketoprofene Lisina Pensa is determined by the prescribing healthcare professional based on the patient’s condition, age, renal and hepatic function, and other individual factors. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety of ketoprofen lysine in pregnancy and lactation has not been definitively established. It is generally advised to avoid NSAIDs, including ketoprofen, during the third trimester of pregnancy and to discuss potential risks with a healthcare provider before use while pregnant or breastfeeding.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request trade or institutional credentials before providing pricing, availability, shipping details and any necessary import documentation.

Both ketoprofen lysine and ibuprofen belong to the NSAID class and share similar mechanisms of COX inhibition. Ketoprofen is often considered slightly more potent on a milligram‑per‑milligram basis, which may allow lower dosing for comparable analgesic effect, but individual response and safety profiles can vary.

Ketoprofene Lisina Pensa should be stored at room temperature, below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability.

The medication is taken orally, usually with a full glass of water. It can be taken with or without food, although taking it with food may reduce gastrointestinal discomfort. Patients should swallow tablets whole and not crush or chew them unless instructed otherwise.

Serious risks include gastrointestinal ulceration or bleeding, severe skin reactions such as Stevens‑Johnson syndrome, renal impairment, hepatic dysfunction, and increased cardiovascular events. Patients should seek immediate medical attention if they experience signs of bleeding, severe rash, sudden kidney problems, or chest pain.

Ketoprofen lysine should be avoided in individuals with known hypersensitivity to ketoprofen or other NSAIDs, those with active gastrointestinal ulcer disease, severe renal or hepatic impairment, uncontrolled hypertension, and patients in the third trimester of pregnancy. A healthcare professional should evaluate suitability before prescribing.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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