Product image of Ketoprofene Sale Di Lisina Zentiva Italia (Ketoprofen Lysine) supplied by GNH India

Ketoprofene Sale Di Lisina Zentiva Italia

Active Ingredient:
Ketoprofen Lysine
Origin:
EU

Ketoprofene Sale Di Lisina Zentiva Italia (Ketoprofen Lysine)

Ketoprofen lysine, the active ingredient in Ketoprofene Sale Di Lisina Zentiva Italia, is a nonsteroidal anti‑inflammatory drug (NSAID) presented as an oral dosage form for systemic use. It is used to relieve pain and inflammation associated with musculoskeletal conditions in adults.

GNH India supplies Ketoprofene Sale Di Lisina Zentiva Italia as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies, clinics and procurement teams worldwide.

Manufacturer / TM Owner

Zentiva Italia S.R.L.

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Indications & Clinical Uses

Ketoprofen lysine is an NSAID that reduces inflammation and pain in several musculoskeletal and acute pain conditions.

  • Rheumatoid arthritis: alleviates joint pain, swelling and stiffness.
  • Osteoarthritis: improves mobility by decreasing joint inflammation.
  • Acute musculoskeletal pain: provides rapid relief after injury or strain.
  • Dental pain: reduces postoperative discomfort following dental procedures.

How It Works

  • Ketoprofen lysine exerts its effect by non‑selectively inhibiting cyclooxygenase‑1 and cyclooxygenase‑2 (COX‑1/COX‑2) enzymes, which blocks the conversion of arachidonic acid to prostaglandins. The resulting decrease in prostaglandin synthesis reduces inflammation, pain signaling, and fever, providing symptomatic relief in inflammatory conditions.

Side Effects

Ketoprofen lysine may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Gastrointestinal upset: nausea, dyspepsia or abdominal pain.
  • Headache: mild to moderate intensity.
  • Dizziness or vertigo.
  • Skin rash or mild itching.
  • Elevated liver enzymes.

Serious or Rare Side Effects

  • Gastrointestinal bleeding or ulceration.
  • Severe renal impairment or acute kidney injury.
  • Cardiovascular events such as myocardial infarction or stroke.
  • Anaphylactic reactions including bronchospasm.
  • Hepatotoxicity with jaundice.

Precautions & Warnings

When prescribing or dispensing ketoprofen lysine, consider the following safety measures.

  • Assess gastrointestinal risk: evaluate history of ulcers or bleeding before use.
  • Monitor renal function: adjust or avoid in patients with existing kidney disease.
  • Evaluate cardiovascular status: use cautiously in those with heart disease.
  • Check for hypersensitivity: discontinue if rash, angioedema, or bronchospasm occurs.
  • Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Ketoprofen lysine can interact with several drug classes; awareness helps prevent adverse outcomes.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of serious bleeding.
  • Selective COX‑2 inhibitors: additive gastrointestinal toxicity.
  • Lithium: potential rise in lithium serum concentrations.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: possible decline in renal function.
  • Diuretics: heightened risk of renal impairment and electrolyte imbalance.
  • Methotrexate: reduced clearance leading to toxicity.

Frequently Asked Questions

Ketoprofene Sale Di Lisina Zentiva Italia contains ketoprofen lysine, an NSAID indicated for the relief of pain and inflammation associated with rheumatoid arthritis, osteoarthritis, acute musculoskeletal injuries, dental pain and other short‑term inflammatory conditions in adult patients.

Ketoprofen lysine works by non‑selectively blocking the cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which reduces the synthesis of prostaglandins. Lower prostaglandin levels diminish inflammation, pain signaling, and fever, providing symptomatic relief in the targeted conditions.

The appropriate dose of ketoprofen lysine is determined by the prescribing clinician based on the specific indication, patient age, weight, renal and hepatic function, and concomitant medications. Patients should follow the prescriber’s instructions and the product label.

Safety of ketoprofen lysine in pregnancy or lactation has not been definitively established. It is generally avoided during the third trimester because of potential fetal cardiovascular effects, and caution is advised while breastfeeding; the prescriber should weigh benefits against possible risks.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Ketoprofen is a propionic‑acid NSAID with a potency comparable to ibuprofen but a slightly longer half‑life, allowing twice‑daily dosing in many cases. Like other NSAIDs, it shares similar gastrointestinal and cardiovascular risk profiles, though individual tolerability may differ among patients.

Ketoprofene should be stored at ambient temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the container tightly closed and out of reach of children.

Ketoprofene is taken orally, usually with a full glass of water. It may be taken with food or milk to lessen gastrointestinal discomfort, but patients should follow the dosing schedule prescribed by their healthcare professional.

Serious risks include gastrointestinal bleeding or ulceration, severe renal impairment, cardiovascular events such as heart attack or stroke, and rare but life‑threatening allergic reactions like anaphylaxis. Patients should seek immediate medical attention if they experience symptoms such as severe abdominal pain, blood in stool, sudden swelling, or difficulty breathing.

Ketoprofene is contraindicated in individuals with known hypersensitivity to ketoprofen or other NSAIDs, those with active gastrointestinal ulceration or bleeding, severe heart failure, and patients who have had a recent coronary artery bypass graft. It should also be used with caution in patients with renal or hepatic impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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