Ketoprofeno Dompe (Ketoprofen Lysine)

Ketoprofeno Dompe, an NSAID, is indicated for inflammatory and painful musculoskeletal conditions.

• Rheumatoid arthritis: reduces joint inflammation and pain, improving mobility.
• Osteoarthritis: alleviates chronic joint pain and helps maintain function.
• Musculoskeletal pain: provides analgesic relief for strains, sprains and other soft‑tissue injuries.

• Ketoprofen lysine exerts its effect by reversibly inhibiting cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, which blocks the conversion of arachidonic acid to prostaglandins. The resulting decrease in prostaglandin synthesis diminishes inflammation, pain signaling, and fever generation at the site of tissue injury.

Ketoprofeno Dompe may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

• Gastrointestinal discomfort, such as dyspepsia or nausea.
• Headache or dizziness.
• Mild skin rash or itching.
• Elevated blood pressure.
• Fluid retention or peripheral edema.
• Transient increase in liver enzymes.

Serious or Rare Side Effects

• Gastrointestinal ulceration or bleeding.
• Severe renal impairment or acute kidney injury.
• Anaphylactic or severe hypersensitivity reactions.
• Stevens‑Johnson syndrome or toxic epidermal necrolysis.
• Hepatotoxicity with jaundice.
• Cardiovascular events such as myocardial infarction or stroke.

Before initiating therapy with Ketoprofeno Dompe, consider the following safety measures.

• Assess renal function: avoid use in severe renal impairment.
• Monitor hepatic function: discontinue if significant liver enzyme elevation occurs.
• Avoid in patients with known hypersensitivity to ketoprofen or other NSAIDs.
• Use caution when combined with anticoagulants or antiplatelet agents due to bleeding risk.
• Limit duration in elderly patients because of increased gastrointestinal complications.
• Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Ketoprofeno Dompe can interact with several drug classes; some combinations should be avoided while others require close monitoring.

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin): heightened risk of serious bleeding.
• Selective COX‑2 inhibitors (e.g., celecoxib): additive gastrointestinal and cardiovascular toxicity.
• High‑dose aspirin: increased gastrointestinal ulcer risk.

Moderate Interactions (Monitor Closely)

• ACE inhibitors or ARBs: possible decline in renal function, especially in volume‑depleted patients.
• Loop or thiazide diuretics: may reduce diuretic efficacy and increase nephrotoxicity.
• Lithium: ketoprofen can raise serum lithium levels, necessitating monitoring.