Product image of Ketorolac Abc (Ketorolac Trometamol) supplied by GNH India

Ketorolac Abc

Active Ingredient:
Ketorolac Trometamol
Origin:
EU

Ketorolac Abc (Ketorolac Trometamol)

Ketorolac Trometamol, the active ingredient in Ketorolac Abc, is a Nonsteroidal anti‑inflammatory drug (NSAID) presented as an injectable solution for intramuscular and intravenous use. It is indicated for short‑term management of moderate to severe acute pain, including post‑operative pain, in adult patients.

GNH India supplies Ketorolac Abc as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Abc Farmaceutici S.P.A.

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Indications & Clinical Uses

Ketorolac Abc acts on the cyclooxygenase pathway to relieve pain and inflammation. It is clinically employed for:

  • Acute postoperative pain: provides rapid analgesia after surgical procedures.
  • Acute musculoskeletal pain: offers short‑term relief of moderate to severe pain from injuries or strains.
  • Renal colic: delivers effective analgesia for severe flank pain episodes.

How It Works

  • Ketorolac trometamol non‑selectively inhibits cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, reducing the conversion of arachidonic acid to prostaglandins. This decrease in prostaglandin synthesis diminishes peripheral sensitisation, inflammation, and fever, resulting in analgesic and anti‑inflammatory effects.

Side Effects

Ketorolac may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Headache: transient pain in the head region.
  • Dizziness: sensation of light‑headedness or unsteadiness.
  • Abdominal pain: discomfort in the stomach area.
  • Injection site pain: local soreness after administration.
  • Constipation: reduced bowel movements.

Serious or Rare Side Effects

  • Gastrointestinal bleeding: potentially life‑threatening hemorrhage.
  • Renal impairment: reduced kidney function, especially with prolonged use.
  • Severe allergic reactions: anaphylaxis, rash, or angioedema.
  • Stevens‑Johnson syndrome: rare skin disorder with blistering.
  • Cardiovascular thrombotic events: increased risk of heart attack or stroke.
  • Hepatic failure: rare liver injury.

Precautions & Warnings

Ketorolac should be used with careful assessment of patient risk factors.

  • Renal function: avoid or adjust dose in patients with impaired kidney function.
  • Bleeding risk: use cautiously in individuals receiving anticoagulants or with active bleeding.
  • Gastrointestinal risk: contraindicated in patients with peptic ulcer disease or prior GI bleeding.
  • Cardiovascular risk: exercise caution in patients with coronary artery disease or hypertension.
  • Pregnancy and lactation: contraindicated in the third trimester; assess risk‑benefit in earlier stages.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Ketorolac can interact with several drug classes, requiring monitoring or avoidance.

Major Interactions (Avoid)

  • Anticoagulants (warfarin, heparin): increased risk of serious bleeding.
  • Other NSAIDs or COX‑2 inhibitors: additive gastrointestinal toxicity.
  • SSRIs and SNRIs: heightened bleeding tendency.
  • ACE inhibitors and diuretics: potential reduction in renal function.
  • Lithium: risk of elevated lithium serum levels.

Moderate Interactions (Monitor Closely)

  • Corticosteroids: increased risk of gastrointestinal ulceration.
  • Methotrexate: reduced clearance may lead to toxicity.

Frequently Asked Questions

Ketorolac Abc is an injectable non‑steroidal anti‑inflammatory drug used for the short‑term management of moderate to severe acute pain, particularly after surgery or in other situations where rapid analgesia is required.

Ketorolac trometamol blocks both COX‑1 and COX‑2 enzymes, which reduces the production of prostaglandins that mediate pain, inflammation, and fever. This inhibition leads to decreased peripheral sensitisation and provides analgesic and anti‑inflammatory effects.

The specific dose and duration are determined by the prescribing clinician based on the patient’s condition, weight, renal function, and procedural context. Ketorolac is typically limited to short‑term use, not exceeding five days.

Ketorolac is generally contraindicated in the third trimester of pregnancy because of the risk of fetal renal impairment and premature closure of the ductus arteriosus. Safety in earlier trimesters and during breastfeeding has not been fully established, so a risk‑benefit assessment is required.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and any required import documentation.

Ketorolac provides analgesia comparable to moderate‑dose opioids for short‑term use but without the risk of respiratory depression. Compared with other NSAIDs, it has a higher potency for pain relief but also a greater risk of renal and gastrointestinal adverse effects, especially when used beyond five days.

Ketorolac Abc injection should be stored at 2‑8 °C, protected from light, and kept in its original container. Do not freeze or shake the vial. If refrigeration is unavailable for a brief period, the product may be kept at controlled room temperature for up to 24 hours, but it should be returned to the refrigerator promptly.

Ketorolac Abc is administered by a healthcare professional via intramuscular or intravenous injection. The injection site should be cleaned with an appropriate antiseptic, and the dose is given slowly to minimise the risk of local irritation or systemic side effects.

The most serious risks include gastrointestinal bleeding or perforation, severe renal impairment, cardiovascular thrombotic events such as heart attack or stroke, and life‑threatening allergic reactions like anaphylaxis. Patients should be monitored closely for signs of these complications.

Ketorolac should be avoided in patients with known hypersensitivity to ketorolac or other NSAIDs, active gastrointestinal bleeding or ulcer disease, severe renal or hepatic impairment, uncontrolled hypertension, and in the third trimester of pregnancy. Caution is also advised for patients on anticoagulants or with a history of cardiovascular disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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