Product image of Ketorolac Accord (Ketorolac Trometamol) supplied by GNH India

Ketorolac Accord

Active Ingredient:
Ketorolac Trometamol
Origin:
EU

Ketorolac Accord (Ketorolac Trometamol)

Ketorolac Trometamol, the active ingredient in Ketorolac Accord, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an oral tablet for oral use. It provides short‑term management of moderate to severe pain, including post‑operative pain, in adult patients.

GNH India supplies Ketorolac Accord as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Accord Healthcare Limited

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Indications & Clinical Uses

Ketorolac Accord is an NSAID used for acute pain conditions where rapid analgesia is required.

  • Moderate to severe acute pain: delivers effective short‑term analgesia for up to five days.
  • Post‑operative pain: reduces pain intensity after surgical procedures.
  • Dental pain: alleviates pain following dental extractions or surgery.

How It Works

  • Ketorolac Trometamol exerts its effect by non‑selectively inhibiting cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which blocks the conversion of arachidonic acid to prostaglandins. The resulting decrease in prostaglandin synthesis reduces inflammation, nociceptor sensitisation and pain signalling at peripheral and central sites.

Side Effects

Ketorolac may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Gastrointestinal discomfort or dyspepsia.
  • Nausea and vomiting.
  • Headache.
  • Dizziness or vertigo.
  • Mild renal function changes.
  • Elevated blood pressure.

Serious or Rare Side Effects

  • Gastrointestinal bleeding or ulceration.
  • Severe renal failure.
  • Anaphylactic or severe allergic reactions.
  • Cardiovascular events such as myocardial infarction.
  • Hepatic dysfunction.
  • Thrombocytopenia or other hematologic abnormalities.

Precautions & Warnings

When prescribing Ketorolac Accord, clinicians should consider several safety measures.

  • Assess renal function: avoid or adjust dose in patients with severe renal impairment.
  • Monitor gastrointestinal risk: use cautiously in individuals with a history of ulcers or bleeding.
  • Check for hypersensitivity: contraindicated in patients with known NSAID allergy.
  • Limit duration: therapy should not exceed five days for most indications.
  • Evaluate bleeding risk: exercise caution when combined with anticoagulants or antiplatelet agents.
  • Store at ambient temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Ketorolac can interact with other medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of serious bleeding.
  • Concurrent NSAIDs or COX‑2 inhibitors: additive gastrointestinal toxicity.
  • Selective serotonin reuptake inhibitors (SSRIs): heightened bleeding tendency.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: may reduce renal perfusion, especially in volume‑depleted patients.
  • Diuretics: combined use can impair renal function.
  • Lithium: ketorolac may raise lithium serum concentrations, requiring monitoring.

Frequently Asked Questions

Ketorolac Accord is a prescription NSAID indicated for the short‑term management of moderate to severe acute pain, including pain after surgery or dental procedures. It is typically used when rapid analgesia is needed for a limited period, usually not exceeding five days.

Ketorolac Trometamol works by non‑selectively blocking the cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which prevents the formation of prostaglandins. Reduced prostaglandin levels lead to decreased inflammation, lower pain signalling, and less sensitisation of nerve endings.

The exact dose and dosing schedule of Ketorolac Accord are determined by the prescribing clinician based on the patient’s condition, age, renal function and other factors. Healthcare professionals should follow local prescribing guidelines and adjust the regimen as needed.

Safety data for Ketorolac Trometamol in pregnancy and lactation are limited. It is generally avoided during the third trimester because of potential fetal renal effects, and caution is advised while breastfeeding. Clinicians should weigh the benefits against potential risks before prescribing.

To request Ketorolac Accord, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Ketorolac is distinguished by its potent analgesic effect, often comparable to weak opioids, making it useful for short‑term severe pain. Unlike many NSAIDs, it is typically limited to a five‑day course because of higher risks of gastrointestinal and renal adverse events.

Ketorolac Accord should be stored at ambient temperature, below 25 °C. Keep the tablets in the original packaging, protect them from moisture and direct sunlight, and ensure the container is tightly closed to maintain product stability.

Ketorolac Accord is taken orally, usually with a full glass of water. The tablet should be swallowed whole and not crushed or chewed. It is recommended to take the medication with food or an antacid to lessen gastrointestinal irritation.

The most serious risks include gastrointestinal bleeding or ulceration, severe renal impairment, cardiovascular events such as myocardial infarction, and life‑threatening allergic reactions. Patients should be monitored closely for signs of these complications, especially when used with other high‑risk drugs.

Ketorolac Accord should be avoided in patients with known hypersensitivity to ketorolac or other NSAIDs, those with active peptic ulcer disease, severe renal or hepatic impairment, uncontrolled hypertension, and in the third trimester of pregnancy. It is also contraindicated in patients receiving anticoagulant therapy where bleeding risk is high.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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