Product image of Ketorolac Aurobindo (Ketorolac Trometamol) supplied by GNH India

Ketorolac Aurobindo

Active Ingredient:
Ketorolac Trometamol
Origin:
EU

Ketorolac Aurobindo (Ketorolac Trometamol)

Ketorolac Trometamol, the active ingredient in Ketorolac Aurobindo, is a nonsteroidal anti‑inflammatory drug (NSAID) presented as an injectable solution for intramuscular or intravenous use. It provides short‑term relief of moderate to severe acute pain, including post‑operative pain, in adult patients requiring rapid analgesia.

GNH India supplies Ketorolac Aurobindo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide. The company adheres to stringent quality standards and provides reliable logistics for global healthcare facilities. Clients benefit from consistent product availability and regulatory compliance across EU and other markets.

Manufacturer / TM Owner

Eugia Pharma (Malta) Ltd

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Indications & Clinical Uses

Ketorolac Aurobindo, an NSAID analgesic, is used for conditions involving acute nociceptive pain.

  • Post‑operative pain: provides rapid analgesia to facilitate recovery after surgical procedures.
  • Acute musculoskeletal pain: reduces pain intensity following injury or strain.
  • Severe acute pain (e.g., after trauma): offers short‑term relief when opioid therapy is not required.

How It Works

  • Ketorolac Trometamol exerts its effect by non‑selectively inhibiting cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, which blocks the conversion of arachidonic acid to prostaglandins. The resulting decrease in prostaglandin synthesis diminishes inflammation, pain signaling, and fever responses at the site of injury.

Side Effects

Ketorolac Aurobindo may be associated with a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Nausea: mild to moderate upset stomach.
  • Vomiting: occasional emesis after dosing.
  • Dyspepsia: discomfort or burning in the upper abdomen.
  • Headache: transient cranial pain.
  • Dizziness: light‑headed sensation.
  • Injection site pain: local discomfort at the administration site.

Serious or Rare Side Effects

  • Gastrointestinal bleeding: potentially life‑threatening hemorrhage.
  • Renal impairment: reduced kidney function or acute failure.
  • Cardiovascular events: increased risk of myocardial infarction or stroke.
  • Severe allergic reactions: anaphylaxis, angioedema, or skin rash.
  • Stevens‑Johnson syndrome: rare but serious skin disorder.
  • Hepatic dysfunction: elevated liver enzymes or hepatitis.

Precautions & Warnings

Ketorolac Aurobindo should be used with caution in patients with specific risk factors.

  • Renal function: avoid or adjust dose in patients with impaired renal function.
  • Bleeding risk: use cautiously in individuals with active bleeding or on anticoagulants.
  • Gastrointestinal history: avoid in patients with peptic ulcer disease or recent GI bleeding.
  • Cardiovascular disease: use with caution in patients with coronary artery disease or hypertension.
  • Pregnancy: avoid in the third trimester and use only if benefits outweigh risks.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Ketorolac Aurobindo can interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin, DOACs): increased risk of serious bleeding.
  • Concurrent NSAIDs or COX‑2 inhibitors: additive gastrointestinal toxicity.
  • SSRIs or SNRIs: heightened bleeding tendency.
  • Lithium: potential elevation of lithium serum levels.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: may reduce renal perfusion when combined.
  • Diuretics: possible decline in renal function.
  • Methotrexate: reduced clearance leading to toxicity.

Frequently Asked Questions

Ketorolac Aurobindo is an injectable nonsteroidal anti‑inflammatory drug indicated for the short‑term management of moderate to severe acute pain, particularly after surgical procedures. It provides rapid analgesia when oral options are insufficient or when a fast onset of pain relief is required.

Ketorolac Trometamol works by non‑selectively blocking the cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which reduces the synthesis of prostaglandins. Lower prostaglandin levels diminish inflammation and interrupt pain signaling pathways, resulting in effective analgesia and anti‑inflammatory effects.

The specific dose and duration of Ketorolac Aurobindo are determined by the prescribing clinician based on the patient’s condition, weight, renal function, and overall risk profile. Healthcare professionals follow local guidelines and product labeling to set an appropriate regimen.

Safety data for Ketorolac Trometamol in pregnancy are limited, and the drug is generally avoided in the third trimester because of potential fetal renal toxicity. Use during pregnancy or lactation should only occur if the prescriber judges that the benefit outweighs the risk, and close monitoring is advised.

To request Ketorolac Aurobindo, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and import documentation.

Ketorolac Aurobindo offers potent analgesia comparable to moderate‑dose opioids but without the risk of respiratory depression. Compared with other NSAIDs such as ibuprofen, it has a faster onset and stronger effect, making it suitable for short‑term, severe pain. However, it carries higher risks of renal and gastrointestinal adverse events, requiring careful patient selection.

The injectable solution should be stored at 2‑8 °C, protected from light, and must not be frozen or shaken. Keep the product in its original packaging until use, and discard any vial that shows particulate matter or discoloration.

Ketorolac Aurobindo is administered by a healthcare professional via intramuscular or intravenous injection. The route, site, and rate of administration are selected by the prescriber based on the clinical situation and patient characteristics.

The most serious risks include gastrointestinal bleeding or perforation, acute renal failure, cardiovascular events such as myocardial infarction or stroke, and severe hypersensitivity reactions including anaphylaxis. Patients should be monitored closely for signs of bleeding, reduced urine output, chest pain, or rash.

Ketorolac Aurobindo is contraindicated in patients with known hypersensitivity to ketorolac or other NSAIDs, active gastrointestinal ulceration or bleeding, severe renal impairment, advanced heart failure, and in the third trimester of pregnancy. It should also be avoided in individuals receiving certain anticoagulants or other NSAIDs without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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