Product image of Ketorolac Baxter (Ketorolac Trometamol) supplied by GNH India

Ketorolac Baxter

Active Ingredient:
Ketorolac Trometamol
Origin:
EU

Ketorolac Baxter (Ketorolac Trometamol)

Ketorolac Trometamol, the active ingredient in Ketorolac Baxter, is a nonsteroidal anti-inflammatory drug presented as a sterile injectable solution for intramuscular and intravenous use. It provides short‑term relief of moderate to severe acute pain, especially after surgery, in adult patients.

GNH India supplies Ketorolac Baxter as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide. The company adheres to stringent quality standards and provides reliable logistics for global distribution. Clients benefit from consistent product availability and regulatory support across multiple regions.

Manufacturer / TM Owner

Baxter Holding B.V.

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Indications & Clinical Uses

  • Ketorolac acts on the cyclooxygenase pathway to relieve pain and inflammation, and is indicated for the following clinical situations.
  • Post‑operative pain: provides short‑term relief of moderate to severe pain after surgical procedures.
  • Acute musculoskeletal pain: reduces pain intensity in severe injuries or trauma.
  • Dental surgery pain: controls pain following oral surgical interventions.

How It Works

  • Ketorolac trometamol non‑selectively inhibits cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, blocking the conversion of arachidonic acid to prostaglandins. By decreasing prostaglandin synthesis, it reduces peripheral sensitization of nociceptors and diminishes inflammatory mediators, resulting in analgesia and anti‑inflammatory effects. The rapid onset after intravenous or intramuscular administration makes it suitable for acute pain management.

Side Effects

Ketorolac may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Nausea
  • Headache
  • Dizziness
  • Injection site pain

Serious or Rare Side Effects

  • Gastrointestinal bleeding
  • Renal impairment
  • Severe allergic reaction (anaphylaxis)
  • Cardiovascular thrombotic events

Precautions & Warnings

  • When using Ketorolac, clinicians should observe several safety considerations to minimize risk.
  • Renal function: assess baseline renal status and avoid prolonged use in patients with impairment.
  • Bleeding risk: avoid in individuals with active ulcers, coagulopathy, or concurrent anticoagulant therapy.
  • Pregnancy: contraindicated in the third trimester and should be used only if benefits outweigh risks during earlier trimesters.
  • Concomitant NSAIDs: limit combined use to reduce gastrointestinal toxicity.
  • Duration of therapy: restrict to a maximum of five days to lower risk of adverse events.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze.

Avoid Interactions

Ketorolac can interact with several drug classes, requiring attention to avoid harmful effects.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin, heparin): increased risk of serious bleeding.
  • Selective COX‑2 inhibitors (e.g., celecoxib): additive renal toxicity.
  • Lithium: ketorolac may raise lithium serum concentrations, risking toxicity.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: may reduce renal function, monitor creatinine.
  • Diuretics: potential for electrolyte disturbances and reduced renal clearance.
  • Methotrexate: decreased clearance leading to toxicity.

Frequently Asked Questions

Ketorolac Baxter is an injectable formulation of ketorolac trometamol, a nonsteroidal anti‑inflammatory drug used for short‑term relief of moderate to severe acute pain, particularly after surgery or other traumatic procedures.

Ketorolac trometamol non‑selectively blocks the cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which reduces the synthesis of prostaglandins. Lower prostaglandin levels diminish inflammation and decrease the sensitivity of pain‑receiving nerves, providing analgesic and anti‑inflammatory effects.

The specific dose and frequency of Ketorolac Baxter are determined by the prescribing clinician based on the patient’s condition, weight, renal function, and the route of administration. The prescriber will set the appropriate regimen according to clinical guidelines.

Ketorolac is generally avoided in the third trimester of pregnancy because it may affect fetal renal function and prolong labor. Limited data exist for earlier trimesters, and the drug passes into breast milk, so it should be used only if the potential benefit outweighs the risk.

To request Ketorolac Baxter, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and import documentation.

Ketorolac is distinguished by its potent analgesic effect, comparable to moderate‑strength opioids, and a rapid onset when given intravenously or intramuscularly. Unlike many NSAIDs, it is typically limited to short‑term use (≤5 days) because of a higher risk of renal and gastrointestinal adverse events.

Ketorolac Baxter should be stored at 2‑8 °C in a refrigerator, protected from light, and must not be frozen or shaken. Keep the vials in their original packaging until use to maintain stability and sterility.

The product is supplied as a sterile solution for intramuscular or intravenous injection. Administration is performed by a qualified healthcare professional, who selects the appropriate route, dose, and infusion rate according to the patient’s clinical needs.

The most serious risks include gastrointestinal bleeding or perforation, acute renal failure, severe allergic reactions such as anaphylaxis, and cardiovascular events like myocardial infarction or stroke, especially with prolonged use or in high‑risk patients.

Ketorolac should be avoided in patients with known hypersensitivity to ketorolac or other NSAIDs, active peptic ulcer disease, significant bleeding disorders, severe renal impairment, third‑trimester pregnancy, and in anyone requiring chronic NSAID therapy beyond five days.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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