Product image of Ketorolac Baxter (Ketorolac Trometamol) supplied by GNH India

Ketorolac Baxter

Active Ingredient:
Ketorolac Trometamol
Origin:
EU

Ketorolac Baxter (Ketorolac Trometamol)

Ketorolac Trometamol, the active ingredient in Ketorolac Baxter, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an injectable solution for intramuscular or intravenous use. It is employed for short‑term management of moderate to severe acute pain, particularly postoperative pain, in adult patients.

GNH India supplies Ketorolac Baxter as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide. The company adheres to stringent quality standards and provides regulatory documentation for global distribution.

Manufacturer / TM Owner

Baxter Holding B.V.

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Indications & Clinical Uses

Ketorolac Trometamol is an NSAID used to control pain by reducing inflammation in the prostaglandin pathway.

  • Postoperative pain: provides rapid analgesia for patients recovering from surgery.
  • Acute moderate to severe pain: offers short‑term relief when opioid therapy is not indicated.
  • Short‑term pain management: limits use to a few days to control intense acute pain episodes.

How It Works

  • Ketorolac Trometamol non‑selectively inhibits cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, blocking the conversion of arachidonic acid to prostaglandins. This reduction in prostaglandin synthesis diminishes inflammation, pain signaling, and fever responses, producing its analgesic and anti‑inflammatory effects.

Side Effects

Ketorolac may cause a range of adverse reactions, which are grouped by frequency and severity.

Common Side Effects

  • Nausea
  • Headache
  • Dizziness
  • Gastrointestinal discomfort
  • Injection‑site pain
  • Elevated blood pressure

Serious or Rare Side Effects

  • Gastrointestinal bleeding or ulceration
  • Acute renal impairment
  • Severe allergic reactions (anaphylaxis)
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis
  • Hepatic dysfunction
  • Cardiovascular thrombotic events

Precautions & Warnings

When prescribing Ketorolac, clinicians should consider several safety measures to minimize risk.

  • Renal function: assess baseline kidney function and avoid prolonged use in patients with impairment.
  • Gastrointestinal risk: use with caution in patients with a history of ulcer disease or bleeding.
  • Cardiovascular status: monitor blood pressure and avoid in patients with uncontrolled hypertension.
  • Concomitant NSAIDs or anticoagulants: avoid combined use to reduce bleeding risk.
  • Pregnancy and lactation: avoid unless benefits outweigh risks; safety not established.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Ketorolac can interact with several drug classes, requiring careful assessment before co‑administration.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin, heparin): increased bleeding risk.
  • Other NSAIDs or aspirin: additive gastrointestinal toxicity.
  • Lithium: elevated lithium levels, risk of toxicity.
  • Methotrexate: reduced clearance, potential toxicity.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: may reduce renal perfusion.
  • Diuretics: risk of renal function decline.
  • SSRIs or SNRIs: heightened bleeding tendency.
  • Beta‑blockers: may blunt antihypertensive effect.

Frequently Asked Questions

Ketorolac Baxter is an injectable form of ketorolac trometamol indicated for the short‑term management of moderate to severe acute pain, especially postoperative pain, in adult patients. It provides rapid analgesia when non‑opioid pain control is required.

Ketorolac trometamol works by non‑selectively inhibiting the cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which blocks the synthesis of prostaglandins. Reduced prostaglandin levels lower inflammation and interrupt pain signaling pathways, delivering its analgesic and anti‑inflammatory effects.

The specific dose and duration of Ketorolac Baxter are determined by the prescribing clinician based on the patient’s condition, weight, renal function, and overall risk profile. Dosing guidelines are provided in the product label and must be followed by the healthcare professional.

Safety of ketorolac during pregnancy and lactation has not been established. It is generally avoided unless the potential benefit justifies the potential risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternatives with their healthcare provider.

To order Ketorolac Baxter, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide, and will request trade or institutional credentials. The team then replies with pricing, availability, shipping details (including cold‑chain if needed), and required import documentation.

Ketorolac provides analgesia comparable to moderate‑dose opioids for short‑term use but carries a lower risk of respiratory depression. Compared with other NSAIDs, it has a higher potency for pain relief but also a higher risk of renal and gastrointestinal adverse effects, so its use is limited to a few days.

Ketorolac Baxter should be stored at 2‑8 °C in a refrigerator, protected from light, and must not be frozen or shaken. Keep the vials in their original packaging until use and discard any solution that appears discolored or contains particles.

Ketorolac Baxter is administered by a healthcare professional as an intramuscular or intravenous injection. The injection is given slowly, and the dose may be repeated only if the total daily limit is not exceeded and the treatment duration remains within recommended limits.

Serious risks include gastrointestinal bleeding or ulceration, acute renal failure, severe allergic reactions such as anaphylaxis, and cardiovascular events like myocardial infarction or stroke. Patients should be monitored for signs of bleeding, changes in urine output, rash, or chest pain during therapy.

Ketorolac should be avoided in patients with known hypersensitivity to ketorolac or other NSAIDs, active gastrointestinal ulceration or bleeding, severe renal impairment, uncontrolled hypertension, and in those who are in the third trimester of pregnancy. Caution is also advised for patients on anticoagulants or with a history of cardiovascular disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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