Product image of Ketorolac Eg (Ketorolac Trometamol) supplied by GNH India

Ketorolac Eg

Active Ingredient:
Ketorolac Trometamol
Origin:
EU

Ketorolac Eg (Ketorolac Trometamol)

Ketorolac Trometamol, the active ingredient in Ketorolac Eg, is a nonsteroidal anti-inflammatory drug (NSAID) presented as a sterile injectable solution for intramuscular and intravenous use. It provides analgesia for moderate to severe pain, particularly postoperative pain, in adult patients and is indicated for short‑term management of acute pain in surgical settings.

GNH India supplies Ketorolac Eg as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, providing reliable batch release, cold‑chain logistics where required, and regulatory support for cross‑border procurement.

Manufacturer / TM Owner

Eg S.P.A.

1
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Indications & Clinical Uses

Ketorolac Trometamol is an NSAID that reduces pain by inhibiting cyclooxygenase‑mediated prostaglandin production.

  • Postoperative pain: provides short‑term relief of moderate to severe pain after surgical procedures.
  • Acute musculoskeletal pain: reduces pain and inflammation associated with sprains, strains, and soft‑tissue injuries.
  • Dental pain: offers rapid analgesia following oral surgery or extractions.
  • Renal colic: alleviates severe flank pain caused by kidney stones.
  • Acute migraine (when other therapies fail): can be used for brief, intense headache relief.

How It Works

  • Ketorolac Trometamol reversibly binds to the cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, blocking the conversion of arachidonic acid to prostaglandins. By lowering prostaglandin synthesis, it diminishes peripheral sensitisation of nociceptors, reduces inflammation, and produces potent analgesic effects without directly acting on opioid receptors.

Side Effects

Ketorolac Trometamol may cause a range of adverse reactions, most of which are dose‑related and reversible.

Common Side Effects

  • Nausea or vomiting
  • Headache
  • Dizziness or vertigo
  • Injection‑site pain or erythema
  • Dyspepsia or abdominal discomfort
  • Diarrhoea

Serious or Rare Side Effects

  • Gastrointestinal bleeding or perforation
  • Acute renal failure or worsening of chronic kidney disease
  • Severe hypersensitivity reactions, including anaphylaxis
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis
  • Cardiovascular thrombotic events such as myocardial infarction or stroke

Precautions & Warnings

Ketorolac should be used with caution, taking into account patient‑specific risk factors and clinical context.

  • Renal function: assess baseline renal status and avoid use in severe renal impairment.
  • Bleeding risk: avoid in patients with active peptic ulcer disease, recent hemorrhage, or concurrent anticoagulant therapy.
  • Cardiovascular disease: use cautiously in patients with coronary artery disease or uncontrolled hypertension.
  • Pregnancy: contraindicated in the third trimester and should be avoided unless benefits outweigh risks.
  • Concomitant NSAIDs or aspirin: avoid combined use to reduce gastrointestinal and renal toxicity.
  • Store below 25°C: keep in the original container, protect from light and moisture.

Avoid Interactions

Ketorolac can interact with several drug classes, altering efficacy or safety.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of serious bleeding.
  • Lithium: ketorolac may raise serum lithium concentrations, risking toxicity.
  • Methotrexate: reduced clearance may lead to methotrexate toxicity.

Moderate Interactions (Monitor Closely)

  • Corticosteroids: combined use heightens the chance of gastrointestinal ulceration.
  • Selective serotonin reuptake inhibitors (SSRIs): may increase bleeding tendency.

Frequently Asked Questions

Ketorolac Eg contains ketorolac trometamol, an NSAID that is primarily used for short‑term relief of moderate to severe pain, especially after surgery or other acute painful conditions such as dental procedures, musculoskeletal injuries, or renal colic.

Ketorolac trometamol blocks the cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, preventing the formation of prostaglandins that sensitize nerve endings and promote inflammation. This inhibition reduces pain signaling and swelling, providing effective analgesia without acting on opioid pathways.

The specific dose and duration of Ketorolac Eg are determined by the prescribing clinician based on the patient’s condition, weight, renal function, and overall risk profile. Healthcare professionals follow local guidelines and product labeling to set an appropriate regimen.

Ketorolac is generally avoided in the third trimester of pregnancy because it may affect fetal circulation. Use during earlier stages or while breastfeeding should only occur if the prescriber judges that the potential benefits outweigh the possible risks to the mother or infant.

To request Ketorolac Eg, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where needed), and any necessary import documentation.

Compared with other NSAIDs, ketorolac provides a higher potency of analgesia, often comparable to weak opioids, but it carries a greater risk of renal and gastrointestinal adverse effects. Unlike opioids, it does not cause respiratory depression, but its use is limited to short‑term therapy to minimise toxicity.

Ketorolac Eg should be stored below 25 °C in its original packaging, protected from light and moisture. The product must be kept in a controlled environment to maintain sterility and potency, and any unused portion should be discarded according to local regulations after the recommended beyond‑use date.

Ketorolac Eg is supplied as a sterile injectable solution for intramuscular or intravenous administration. The route, injection site, and infusion rate are selected by the healthcare professional, who follows standard aseptic techniques and monitors the patient for any immediate adverse reactions.

The most serious risks include gastrointestinal bleeding or perforation, acute renal failure, severe hypersensitivity reactions such as anaphylaxis, and cardiovascular events like myocardial infarction or stroke, particularly when used in high‑risk patients or for longer than recommended.

Ketorolac Eg is contraindicated in patients with known hypersensitivity to ketorolac or other NSAIDs, those with active peptic ulcer disease, severe renal impairment, recent coronary artery bypass graft surgery, and in the third trimester of pregnancy. It should also be avoided in patients receiving other NSAIDs or aspirin without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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