Product image of Ketorolac Eg (Ketorolac Trometamol) supplied by GNH India

Ketorolac Eg

Active Ingredient:
Ketorolac Trometamol
Origin:
EU

Ketorolac Eg (Ketorolac Trometamol)

Ketorolac, the active ingredient in Ketorolac Eg, is a non‑steroidal anti‑inflammatory drug (NSAID) presented as an oral dosage form for oral use. It provides short‑term relief of moderate to severe acute pain, including post‑operative and musculoskeletal pain, in adult patients.

GNH India supplies Ketorolac Eg as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Eg S.P.A.

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Indications & Clinical Uses

  • Ketorolac is an NSAID that reduces pain and inflammation through cyclooxygenase inhibition.
  • Acute postoperative pain: provides rapid analgesia after surgical procedures.
  • Musculoskeletal pain: alleviates pain associated with injuries or inflammatory conditions of muscles and joints.
  • Severe acute pain: offers short‑term relief for conditions such as renal colic or trauma where prompt pain control is required.

How It Works

  • Ketorolac trometamol non‑selectively inhibits cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, decreasing the conversion of arachidonic acid to prostaglandins. Reduced prostaglandin synthesis leads to diminished inflammation, pain signaling, and fever responses at sites of tissue injury.

Side Effects

Ketorolac may cause a range of adverse reactions.

Common Side Effects

  • Gastrointestinal discomfort or dyspepsia
  • Nausea or vomiting
  • Headache
  • Dizziness or vertigo
  • Constipation
  • Mild, reversible increase in serum creatinine

Serious or Rare Side Effects

  • Gastrointestinal bleeding or ulceration
  • Severe renal impairment or failure
  • Cardiovascular events such as myocardial infarction or stroke
  • Anaphylactic or severe allergic reactions
  • Hepatic dysfunction or jaundice
  • Thrombocytopenia or other hematologic abnormalities

Precautions & Warnings

  • Ketorolac should be used with caution and under medical supervision.
  • Renal function: assess baseline renal status and avoid use in severe renal impairment.
  • Bleeding risk: use cautiously in patients receiving anticoagulants or with a history of ulcers.
  • Cardiovascular: avoid in patients with uncontrolled hypertension or recent myocardial infarction.
  • Pregnancy and lactation: prescribe only if benefits outweigh potential risks; safety not established.
  • Drug interactions: review concomitant NSAIDs, anticoagulants, and ACE inhibitors before initiating therapy.
  • Store at ambient temperature: keep below 25 °C, protect from moisture and light in the original packaging.

Avoid Interactions

Ketorolac can interact with several drug classes, requiring careful assessment.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of serious bleeding.
  • Other NSAIDs or COX‑2 inhibitors: additive gastrointestinal toxicity.
  • Selective serotonin reuptake inhibitors (SSRIs): heightened bleeding tendency.

Moderate Interactions (Monitor Closely)

  • Diuretics: may reduce renal clearance and exacerbate renal effects.
  • Methotrexate: decreased excretion can lead to toxicity.

Frequently Asked Questions

Ketorolac Eg is prescribed for the short‑term management of moderate to severe acute pain, including post‑operative pain and musculoskeletal pain. It is typically used when rapid analgesia is needed for a limited duration, usually not exceeding five days of oral therapy.

Ketorolac works by non‑selectively inhibiting the cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which reduces the synthesis of prostaglandins. Lower prostaglandin levels diminish inflammation and pain signaling at the site of tissue injury.

The specific oral dose of ketorolac is determined by the prescribing clinician based on the patient’s condition, age, renal function, and other factors. Dosage regimens are individualized and should follow the prescriber’s instructions.

Safety data for ketorolac during pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Ketorolac is generally more potent as an analgesic compared with many traditional NSAIDs, making it suitable for short‑term, high‑intensity pain control. However, its risk profile for gastrointestinal and renal adverse effects is also higher, so it is reserved for brief use under medical supervision.

Ketorolac Eg should be stored at ambient temperature, preferably below 25 °C, in its original container to protect it from moisture and light. Keep the product out of reach of children and do not use it after the expiration date.

Ketorolac Eg is administered orally, usually as a tablet or oral solution, and should be taken with a full glass of water. It may be taken with or without food, but taking it with food can reduce gastrointestinal irritation.

Serious risks include gastrointestinal bleeding or ulceration, severe renal impairment, cardiovascular events such as myocardial infarction or stroke, and severe allergic reactions including anaphylaxis. Patients should seek immediate medical attention if they experience signs of these conditions.

Ketorolac is contraindicated in patients with known hypersensitivity to ketorolac or other NSAIDs, active gastrointestinal bleeding or ulcer disease, severe renal impairment, advanced heart failure, and in the peri‑operative setting for coronary artery bypass graft surgery. It should also be avoided in patients receiving certain anticoagulants without careful risk assessment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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