Ketorolac Micro Labs (Ketorolac Trometamol)

Ketorolac Trometamol ophthalmic NSAID is used to manage inflammation and pain in ocular surgical settings.

• Post‑operative ocular inflammation: reduces swelling and redness after eye surgery.
• Ocular pain: alleviates discomfort and ache following ocular procedures.
• Inflammation after cataract surgery: controls inflammatory response to improve visual recovery.

• Ketorolac Trometamol exerts its effect by non‑selectively inhibiting cyclooxygenase‑1 and cyclooxygenase‑2 enzymes in ocular tissues. This blockade decreases the conversion of arachidonic acid to prostaglandins, which are mediators of inflammation, pain and vasodilation. Reduced prostaglandin synthesis leads to diminished inflammatory cell infiltration and relief of ocular discomfort. The drug penetrates the cornea and conjunctiva, achieving therapeutic concentrations in the anterior chamber.

Ketorolac ophthalmic solution may cause local ocular reactions and, rarely, more serious ocular events.

Common Side Effects

• Burning or stinging sensation: transient discomfort upon instillation.
• Redness of the eye: mild conjunctival hyperemia.
• Itching: mild pruritus.
• Blurred vision: temporary visual disturbance.

Serious or Rare Side Effects

• Corneal ulceration: rare but severe corneal epithelial breakdown.
• Increased intra‑ocular pressure: may exacerbate glaucoma.
• Allergic reaction: swelling, rash or severe eye irritation.

When prescribing Ketorolac ophthalmic solution, consider the following precautions to ensure safe use.

• Hypersensitivity: avoid use in patients with known allergy to ketorolac or other NSAIDs.
• Corneal disease: use with caution in patients with compromised corneal integrity.
• Glaucoma: monitor intra‑ocular pressure as NSAIDs may affect pressure.
• Concurrent ocular NSAIDs: do not combine with other NSAID eye drops to prevent additive irritation.
• Pregnancy and lactation: safety not established; weigh benefits against potential risks.
• Store at room temperature: keep in original container, protect from light and moisture.

Ketorolac ophthalmic solution can interact with systemic and ocular medications; awareness of these interactions helps minimize adverse outcomes.

Major Interactions (Avoid)

• Systemic anticoagulants (e.g., warfarin): increased risk of bleeding.
• Systemic NSAIDs: additive inhibition of prostaglandins may raise systemic side‑effect risk.
• Aspirin therapy: heightened bleeding tendency.

Moderate Interactions (Monitor Closely)

• Topical corticosteroids: may mask signs of infection or inflammation.
• Other ocular drugs (e.g., beta‑blocker eye drops): may alter absorption.
• Contact lens wear: may increase drug retention and irritation.