Product image of Ketorolac S.A.L.F. (Ketorolac Trometamol) supplied by GNH India

Ketorolac S.A.L.F.

Active Ingredient:
Ketorolac Trometamol
Origin:
EU

Ketorolac S.A.L.F. (Ketorolac Trometamol)

Ketorolac, the active ingredient in Ketorolac S.A.L.F., is a nonsteroidal anti-inflammatory drug presented as an injectable solution for intramuscular and intravenous use. It treats moderate to severe acute pain, particularly post‑operative pain, in adult patients.\n\nGNH India supplies Ketorolac S.A.L.F. as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, clinics and procurement teams worldwide, ensuring quality, reliable logistics and full regulatory documentation for global distribution.

Manufacturer / TM Owner

S.A.L.F. Spa Laboratorio Farmacologico

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Indications & Clinical Uses

  • Ketorolac is a nonsteroidal anti‑inflammatory drug used to manage pain by inhibiting prostaglandin synthesis.\n\n- Acute moderate to severe pain: provides rapid analgesia for up to five days.\n- Post‑operative pain: reduces pain intensity after surgical procedures.\n- Short‑term management of severe acute pain: offers effective relief when opioid therapy is not preferred.

How It Works

  • Ketorolac trometamol non‑selectively inhibits cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, blocking the conversion of arachidonic acid to prostaglandins. This reduction in prostaglandin synthesis diminishes peripheral sensitization, inflammation, and pain signaling, resulting in analgesic and anti‑inflammatory effects.

Side Effects

  • Ketorolac may cause a range of adverse reactions, varying from mild to severe.\n\nCommon Side Effects:\n- Nausea: mild to moderate upset stomach.\n- Headache: transient cranial discomfort.\n- Dizziness: occasional light‑headed feeling.\n- Injection‑site pain: local soreness or irritation.\n- Gastrointestinal discomfort: dyspepsia or abdominal pain.\n- Vomiting: occasional emesis.\n- Diarrhea: loose stools.\n\nSerious or Rare Side Effects:\n- Gastrointestinal bleeding: potentially life‑threatening hemorrhage.\n- Renal impairment: reduced kidney function, especially with prolonged use.\n- Severe allergic reactions: anaphylaxis, angioedema, or skin rash.\n- Cardiovascular events: myocardial infarction or stroke risk.\n- Liver enzyme elevation: abnormal hepatic function tests.

Precautions & Warnings

  • When using ketorolac, clinicians should consider several safety precautions to minimize risk.\n\n- Renal function: assess baseline kidney status and avoid in severe impairment.\n- Bleeding risk: contraindicated in active gastrointestinal ulcer or coagulopathy.\n- Cardiovascular disease: use cautiously in patients with heart disease history.\n- Pregnancy and lactation: avoid unless benefits clearly outweigh potential risks.\n- Concomitant NSAIDs: limit combined use to reduce additive toxicity.\n- Store at ambient temperature: keep in original container, protect from light and moisture.

Avoid Interactions

  • Ketorolac can interact with several medicines, altering its safety or effectiveness.\n\nMajor Interactions (Avoid):\n- Anticoagulants (e.g., warfarin, heparin): increased risk of serious bleeding.\n- Other NSAIDs or COX‑2 inhibitors: heightened gastrointestinal toxicity.\n\nModerate Interactions (Monitor Closely):\n- ACE inhibitors or diuretics: may reduce renal function; monitor creatinine.\n- Lithium: NSAIDs can raise lithium levels; monitor serum.\n- Methotrexate: reduced clearance may cause toxicity; adjust dose if needed.

Frequently Asked Questions

Ketorolac S.A.L.F. is indicated for the short‑term management of moderate to severe acute pain, especially post‑operative pain. It provides rapid analgesia for up to five days and is typically reserved for situations where opioid therapy is not required or is being avoided.

Ketorolac works by non‑selectively inhibiting the cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which blocks the formation of prostaglandins. Reduced prostaglandin levels decrease inflammation and peripheral sensitisation, leading to effective pain relief.

The exact dose and duration are determined by the prescribing clinician based on the patient’s condition, age, renal function and other factors. In practice, adult dosing is often limited to a maximum of five days of therapy to minimise adverse effects.

Safety data for ketorolac during pregnancy and lactation are limited. Because it may affect fetal renal function and prostaglandin pathways, it is generally avoided unless the potential benefit justifies the risk. Breast‑feeding mothers should also consult a healthcare professional before use.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and any required import documentation.

Ketorolac offers analgesic potency comparable to many opioid agents but without the risk of respiratory depression. Compared with other NSAIDs, it has a higher risk of renal and gastrointestinal adverse effects, so it is usually reserved for short‑term, high‑intensity pain control.

Ketorolac injectable solution should be stored at ambient temperature, below 25 °C, in its original packaging. Protect it from direct light, moisture and extreme temperatures. Do not freeze the product, and keep the vial sealed until use.

Ketorolac is given by intramuscular or intravenous injection. The route, volume and rate of administration are determined by the prescriber, who will also monitor the patient for efficacy and any adverse reactions during and after the injection.

The most serious risks include gastrointestinal bleeding, severe renal impairment, cardiovascular events such as myocardial infarction or stroke, and life‑threatening allergic reactions (anaphylaxis). Patients should be monitored closely for signs of these complications, especially when used with other high‑risk medications.

Ketorolac is contraindicated in patients with active peptic ulcer disease, severe renal or hepatic impairment, known hypersensitivity to NSAIDs, recent coronary artery bypass graft surgery, and those receiving anticoagulant therapy where bleeding risk is unacceptable. It should also be avoided in pregnant women near term.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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