Product image of Ketorolac Trometamol Baxter Healthcare (Ketorolac Trometamol) supplied by GNH India

Ketorolac Trometamol Baxter Healthcare

Active Ingredient:
Ketorolac Trometamol
Origin:
EU

Ketorolac Trometamol Baxter Healthcare (Ketorolac Trometamol)

Ketorolac Trometamol, the active ingredient in Ketorolac Trometamol Baxter Healthcare, is a non‑steroidal anti‑inflammatory drug presented as an injectable solution for intramuscular and intravenous administration. It is indicated for the management of moderate to severe acute pain, including postoperative pain, in adult patients requiring short‑term analgesia.

GNH India supplies Ketorolac Trometamol Baxter Healthcare as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The product complies with EU regulatory standards and is distributed across multiple regions globally.

Manufacturer / TM Owner

Baxter Healthcare Ltd.

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Indications & Clinical Uses

  • Ketorolac Trometamol is an NSAID that provides analgesia by inhibiting cyclooxygenase enzymes involved in pain pathways.
  • Moderate to severe acute pain: delivers rapid pain relief for adult patients experiencing intense short‑term pain.
  • Post‑operative pain: reduces discomfort following surgical procedures, facilitating early mobilization and recovery.
  • Short‑term pain management when opioids are unsuitable: offers an alternative analgesic option for patients with contraindications to opioid therapy.

How It Works

  • Ketorolac Trometamol non‑selectively inhibits cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, blocking the conversion of arachidonic acid to prostaglandins. This reduction in prostaglandin synthesis diminishes inflammation, peripheral sensitization, and central pain signaling, resulting in effective analgesia for acute painful conditions.

Side Effects

Ketorolac Trometamol may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Nausea
  • Headache
  • Dizziness
  • Injection‑site pain or irritation
  • Gastrointestinal discomfort
  • Constipation

Serious or Rare Side Effects

  • Acute renal impairment or failure
  • Severe bleeding or gastrointestinal ulceration
  • Anaphylactic or severe allergic reactions
  • Cardiovascular events such as myocardial infarction or stroke
  • Hepatic dysfunction or elevated liver enzymes
  • Thrombocytopenia or other hematologic abnormalities

Precautions & Warnings

When using Ketorolac Trometamol, clinicians should observe several safety measures.

  • Assess renal function: avoid or adjust use in patients with severe renal impairment.
  • Monitor bleeding risk: use cautiously with anticoagulants or antiplatelet agents.
  • Check for NSAID hypersensitivity: discontinue if allergic reactions occur.
  • Limit duration: prescribe the lowest effective dose for no more than five days.
  • Pregnancy and lactation: use only if benefits outweigh potential risks.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Ketorolac Trometamol can interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of serious bleeding.
  • Other NSAIDs or COX‑2 inhibitors: additive gastrointestinal and renal toxicity.
  • ACE inhibitors or ARBs: may precipitate acute renal failure.

Moderate Interactions (Monitor Closely)

  • Diuretics: monitor renal function and electrolytes.
  • Lithium: ketorolac can raise lithium serum levels.
  • Methotrexate: reduced clearance may increase toxicity.

Frequently Asked Questions

Ketorolac Trometamol is an injectable non‑steroidal anti‑inflammatory drug used to treat moderate to severe acute pain, including pain that follows surgery. It provides rapid analgesia for adult patients who need short‑term pain control when other options may be unsuitable.

The drug works by non‑selectively blocking the cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which are essential for prostaglandin production. Lower prostaglandin levels reduce inflammation and interrupt pain signaling pathways, resulting in effective relief of acute pain.

The specific dose and duration of Ketorolac Trometamol are determined by the prescribing clinician based on the patient’s condition, weight, renal function, and overall risk profile. Healthcare professionals follow local guidelines and product labeling to set an appropriate regimen.

Safety data for Ketorolac Trometamol during pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and only under direct medical supervision.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and any required import documentation.

Ketorolac offers potent analgesia comparable to moderate‑dose opioids but without the risk of respiratory depression. Compared with other NSAIDs, it has a higher risk of renal and gastrointestinal adverse effects, so clinicians often reserve it for short‑term use when strong pain relief is needed quickly.

The injectable solution should be stored at 2‑8 °C, protected from light, and must not be frozen or shaken. Keep the product in its original packaging until use and discard any solution that appears discolored or contains particles.

Ketorolac Trometamol is given by intramuscular or intravenous injection. The route, injection site, and infusion rate are selected by the healthcare professional according to the clinical situation and patient tolerance.

The most critical risks include acute renal failure, severe bleeding or gastrointestinal ulceration, cardiovascular events such as myocardial infarction or stroke, and severe allergic reactions including anaphylaxis. Patients should be monitored closely for signs of these complications.

Ketorolac is contraindicated in patients with known hypersensitivity to ketorolac or other NSAIDs, those with active peptic ulcer disease, severe renal impairment, uncontrolled hypertension, and in the peri‑operative setting for coronary artery bypass graft surgery. Caution is also advised for patients on anticoagulants or with cardiovascular disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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