Product image of Ketorolac Trometamol Kent Pharma Uk (Ketorolac Trometamol) supplied by GNH India

Ketorolac Trometamol Kent Pharma Uk

Active Ingredient:
Ketorolac Trometamol
Origin:
EU

Ketorolac Trometamol Kent Pharma Uk (Ketorolac Trometamol)

Ketorolac trometamol, the active ingredient in Ketorolac Trometamol Kent Pharma Uk, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an injectable solution for intramuscular and intravenous use. It provides short‑term relief of moderate to severe pain, especially after surgery, in adult patients.

GNH India supplies Ketorolac Trometamol Kent Pharma Uk as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Kent Pharma Uk Limited

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Indications & Clinical Uses

Ketorolac trometamol is an NSAID used for acute pain conditions where rapid analgesia is required.

  • Post‑operative pain: provides short‑term relief of moderate to severe pain after surgical procedures.
  • Acute musculoskeletal pain: reduces pain and inflammation following injury or trauma.
  • Dental pain: alleviates severe pain after dental extractions or other oral surgeries.

How It Works

  • Ketorolac trometamol inhibits cyclooxygenase (COX‑1 and COX‑2) enzymes, decreasing the synthesis of prostaglandins that mediate inflammation, pain, and fever. By reducing prostaglandin levels at the site of tissue injury, it diminishes peripheral sensitisation of nociceptors and produces potent analgesic effects within a short time after administration.

Side Effects

Adverse reactions may range from mild to severe and should be monitored during therapy.

Common Side Effects

  • Nausea
  • Headache
  • Dizziness
  • Injection site pain

Serious or Rare Side Effects

  • Gastrointestinal bleeding or ulceration
  • Acute renal failure
  • Severe allergic reaction (anaphylaxis)

Precautions & Warnings

Ketorolac trometamol requires careful assessment of patient risk factors before use.

  • Renal function: evaluate baseline kidney function and avoid in severe impairment.
  • Bleeding risk: avoid in patients with active peptic ulcer disease or recent major surgery.
  • Cardiovascular disease: use cautiously in patients with coronary artery disease or hypertension.
  • Pregnancy: avoid unless benefits clearly outweigh potential risks.
  • Concomitant NSAIDs: do not combine with other NSAIDs or COX‑2 inhibitors.
  • Store at below 25°C: keep in the original container, protect from moisture and light.

Avoid Interactions

Ketorolac trometamol can interact with several drug classes, altering safety or efficacy.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of serious bleeding.
  • Other NSAIDs or COX‑2 inhibitors: additive gastrointestinal toxicity.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: may reduce renal perfusion and function.
  • Diuretics: heightened risk of renal impairment.
  • Lithium: ketorolac can raise serum lithium concentrations, requiring monitoring.

Frequently Asked Questions

Ketorolac Trometamol is an injectable NSAID indicated for the short‑term management of moderate to severe acute pain, such as post‑operative pain, acute musculoskeletal injuries, and dental pain, when rapid analgesia is required.

The drug blocks cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which reduces the production of prostaglandins. Lower prostaglandin levels decrease inflammation and peripheral sensitisation of pain receptors, providing potent analgesic effects.

The specific dose and duration are determined by the prescribing clinician based on the patient’s condition, weight, renal function, and route of administration. Ketorolac is typically limited to a maximum of five days of therapy.

Ketorolac is generally avoided during pregnancy, especially in the third trimester, because of potential fetal renal effects and bleeding risk. Limited data exist for breastfeeding; therefore, use should be considered only if the potential benefit justifies the possible risk to the infant.

Enquiries are submitted via the product page on gnhindia.com, where you specify the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if required), and necessary import documentation.

Ketorolac is distinguished by its strong analgesic potency, comparable to moderate‑strength opioids, and a rapid onset when given intravenously or intramuscularly. Unlike many NSAIDs, it is typically reserved for short‑term use because of higher risks of renal and gastrointestinal adverse effects.

The product should be stored below 25 °C in its original packaging, protected from moisture and light. Do not freeze. Inspect the vial for particulate matter before use and discard if the solution appears discoloured.

Ketorolac Trometamol is supplied for intramuscular or intravenous injection. The preparation is reconstituted according to the manufacturer’s instructions and administered by a qualified healthcare professional, typically as a single dose or repeated doses under strict time limits.

Serious risks include gastrointestinal bleeding or ulceration, acute renal failure, severe allergic reactions such as anaphylaxis, and cardiovascular events like myocardial infarction or stroke, particularly in patients with existing risk factors.

Ketorolac is contraindicated in patients with known hypersensitivity to ketorolac or other NSAIDs, active peptic ulcer disease, severe renal impairment, recent coronary artery bypass graft surgery, and in those receiving anticoagulant therapy where bleeding risk is unacceptable.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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