Product image of Ketorolac Trometamol Misom (Ketorolac Trometamol) supplied by GNH India

Ketorolac Trometamol Misom

Active Ingredient:
Ketorolac Trometamol
Origin:
EU

Ketorolac Trometamol Misom (Ketorolac Trometamol)

Ketorolac Trometamol, the active ingredient in Ketorolac Trometamol Misom, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an ophthalmic solution for ocular use. It is employed to reduce inflammation and pain following eye surgery and in various inflammatory eye conditions.

GNH India supplies Ketorolac Trometamol Misom as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide, ensuring quality and regulatory compliance across markets.

Manufacturer / TM Owner

Misom Labs Limited

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Indications & Clinical Uses

Ketorolac Trometamol acts on ocular inflammatory pathways to relieve pain and swelling. It is indicated for:

  • Post‑operative ocular inflammation: reduces swelling after eye surgery.
  • Post‑operative ocular pain: alleviates discomfort following ocular procedures.
  • Inflammatory eye conditions: diminishes inflammation in conjunctivitis and keratitis.
  • Uveitis: helps control intraocular inflammation associated with uveitic episodes.

How It Works

  • Ketorolac Trometamol reversibly inhibits cyclooxygenase‑1 and cyclooxygenase‑2 enzymes in ocular tissues, decreasing the conversion of arachidonic acid to prostaglandins. The reduction in prostaglandin synthesis leads to diminished inflammatory mediator release, resulting in lowered inflammation, edema, and pain within the eye.

Side Effects

Ketorolac Trometamol may cause local ocular reactions, ranging from mild to serious.

Common Side Effects

  • Burning or stinging sensation upon instillation.
  • Transient blurred vision.
  • Increased tearing.
  • Foreign body sensation.
  • Mild conjunctival hyperemia.
  • Temporary eyelid edema.

Serious or Rare Side Effects

  • Corneal ulceration or epithelial defect.
  • Severe allergic reaction, including angioedema.
  • Marked increase in intraocular pressure.
  • Persistent epithelial defect leading to vision loss.
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis (rare).

Precautions & Warnings

Ketorolac Trometamol should be used with careful clinical judgment.

  • Assess patient history: verify no known hypersensitivity to NSAIDs or ocular formulations.
  • Avoid use in active ocular infection unless directed by a specialist.
  • Use with caution in patients with pre‑existing corneal disorders or compromised epithelial integrity.
  • Monitor intraocular pressure in patients with glaucoma or ocular hypertension.
  • Do not combine with other ocular NSAIDs without professional guidance.
  • Store at room temperature: keep in the original container, protect from light and moisture.

Avoid Interactions

Ketorolac Trometamol can interact with systemic and ocular agents.

Major Interactions (Avoid)

  • Systemic NSAIDs or aspirin: additive risk of bleeding and delayed wound healing.
  • Anticoagulants (e.g., warfarin, direct oral anticoagulants): increased ocular bleeding risk.
  • Topical corticosteroids: potential antagonism of anti‑inflammatory effects.

Moderate Interactions (Monitor Closely)

  • Ocular prostaglandin analogs for glaucoma: may reduce efficacy of pressure‑lowering therapy.
  • Beta‑blocker eye drops: possible additive ocular hypotensive effects.
  • Antihistamine eye drops: may increase dryness and discomfort.

Frequently Asked Questions

Ketorolac Trometamol Misom is an ophthalmic solution prescribed to manage post‑operative inflammation and pain after eye surgery, as well as to treat inflammatory eye conditions such as conjunctivitis, keratitis, and uveitis. It works locally in the eye to reduce swelling, redness, and discomfort.

The active ingredient, Ketorolac Trometamol, blocks cyclooxygenase‑1 and cyclooxygenase‑2 enzymes in ocular tissues, preventing the formation of prostaglandins that drive inflammation and pain. By lowering prostaglandin levels, the drug reduces vascular permeability, edema, and nociceptive signaling within the eye.

The specific dosing regimen for Ketorolac Trometamol Misom is determined by the prescribing ophthalmologist based on the type of surgery, severity of inflammation, and individual patient factors. The prescriber will provide exact instructions on the number of drops, frequency, and duration of therapy.

The safety of Ketorolac Trometamol in pregnancy and lactation has not been definitively established. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and this decision must be made by the treating physician in consultation with the patient.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain needs), and required import documentation.

Ketorolac Trometamol is a non‑steroidal anti‑inflammatory drug, offering anti‑inflammatory and analgesic effects without the steroid‑related risks of cataract formation or intraocular pressure rise. Compared with steroid eye drops, it has a lower risk of steroid‑induced glaucoma but may be less potent for severe uveitis, making it suitable for many postoperative and mild‑to‑moderate inflammatory conditions.

Ketorolac Trometamol Misom should be stored at room temperature, below 25 °C, in its original packaging to protect it from light and moisture. The container should be tightly closed, and any unused portion should be discarded after the labeled expiry date to ensure efficacy and safety.

The product is applied as eye drops. The prescriber will instruct the patient on the number of drops per eye, the frequency (e.g., one to two drops several times daily), and the duration of treatment. Proper hand hygiene and avoidance of contact between the dropper tip and the ocular surface are essential.

Serious adverse events, though rare, include corneal ulceration, severe allergic reactions such as angioedema, marked increases in intraocular pressure, and rare systemic hypersensitivity reactions like Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they experience persistent pain, vision changes, or signs of a severe allergic response.

Ketorolac Trometamol Misom is contraindicated in individuals with known hypersensitivity to ketorolac, other NSAIDs, or any component of the formulation. It should also be avoided in patients with active ocular infections, severe corneal disease, or those using other ocular NSAIDs unless specifically directed by a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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