Product image of Ketorolac Trometamol Rompharm (Ketorolac Trometamol) supplied by GNH India

Ketorolac Trometamol Rompharm

Active Ingredient:
Ketorolac Trometamol
Origin:
EU

Ketorolac Trometamol Rompharm (Ketorolac Trometamol)

Ketorolac Trometamol, the active ingredient in Ketorolac Trometamol Rompharm, is a nonsteroidal anti‑inflammatory drug (NSAID) formulated as an injectable solution for intramuscular or intravenous administration. It provides potent analgesia for the short‑term management of moderate to severe acute pain, such as post‑operative pain, in adult patients.

GNH India supplies Ketorolac Trometamol Rompharm as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality and regulatory conformity across global markets and meeting the specific needs of healthcare providers.

Manufacturer / TM Owner

S.C. Rompharm Company S.R.L.

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Indications & Clinical Uses

Ketorolac Trometamol is an NSAID that provides analgesia by inhibiting prostaglandin synthesis in acute pain conditions.

  • Post‑operative pain: rapid relief of moderate to severe pain following surgical procedures.
  • Acute musculoskeletal pain: reduction of pain intensity after injuries or trauma.
  • Short‑term severe pain: effective non‑opioid option for managing acute pain when opioid therapy is not indicated.

How It Works

  • Ketorolac Trometamol non‑selectively inhibits cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, blocking the conversion of arachidonic acid to prostaglandins. The resulting decrease in prostaglandin synthesis reduces inflammation, nociceptor sensitization, and pain signaling, producing potent analgesic and anti‑inflammatory effects after intramuscular or intravenous administration.

Side Effects

Ketorolac Trometamol may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Nausea: transient feeling of sickness.
  • Headache: mild to moderate intensity.
  • Injection site pain: local discomfort at the administration site.
  • Dizziness: occasional light‑headedness.
  • Gastrointestinal upset: includes dyspepsia or mild abdominal discomfort.

Serious or Rare Side Effects

  • Gastrointestinal bleeding or ulceration: potentially life‑threatening.
  • Renal impairment: reduced kidney function, especially in at‑risk patients.
  • Severe hypersensitivity reactions: including anaphylaxis or skin rash.
  • Cardiovascular events: such as myocardial infarction or stroke.
  • Hematologic abnormalities: thrombocytopenia or bleeding disorders.
  • Stevens‑Johnson syndrome: rare but serious skin reaction.

Precautions & Warnings

Ketorolac Trometamol requires careful assessment before use to minimise risk.

  • Renal function: evaluate kidney status and avoid in severe renal impairment.
  • Bleeding risk: contraindicated in active peptic ulcer disease or coagulopathy.
  • Cardiovascular disease: use cautiously in patients with coronary artery disease.
  • Pregnancy and lactation: safety not established; generally avoided.
  • Concomitant NSAIDs or anticoagulants: increased risk of gastrointestinal bleeding.
  • Store at ambient temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Ketorolac Trometamol can interact with several drug classes, requiring vigilance.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin, heparin): heightened bleeding risk.
  • Other NSAIDs or COX‑2 inhibitors: additive gastrointestinal toxicity.
  • Selective serotonin reuptake inhibitors (SSRIs): increased potential for bleeding.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors: may reduce renal perfusion when combined.
  • Diuretics: risk of renal impairment, especially in dehydrated patients.
  • Lithium: possible increase in serum lithium concentrations.

Frequently Asked Questions

Ketorolac Trometamol Rompharm is an injectable NSAID indicated for the short‑term management of moderate to severe acute pain, such as post‑operative pain or pain following trauma. It provides rapid analgesia when administered intramuscularly or intravenously and is typically used when opioid therapy is not required.

Ketorolac Trometamol works by non‑selectively inhibiting the cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which blocks the synthesis of prostaglandins. Reduced prostaglandin levels diminish inflammation and nociceptor sensitisation, leading to effective pain relief and anti‑inflammatory effects.

The specific dose and duration of Ketorolac Trometamol Rompharm are determined by the prescribing clinician based on the patient’s condition, weight, renal function and other clinical factors. Healthcare professionals follow local guidelines and product labeling to set an appropriate regimen.

Safety of Ketorolac Trometamol during pregnancy and lactation has not been established. Because of potential risks to the fetus and newborn, it is generally avoided in pregnant or nursing women unless the benefits clearly outweigh the risks and a qualified healthcare provider approves its use.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and the necessary import documentation.

Ketorolac Trometamol offers potent non‑opioid analgesia comparable to stronger NSAIDs but with a faster onset than many oral formulations. Unlike opioids, it does not cause respiratory depression, but it shares typical NSAID risks such as gastrointestinal bleeding and renal effects. It is often chosen when a short‑acting, injectable analgesic is required.

The product should be stored at ambient temperature, below 25 °C, in its original packaging. Protect it from direct light, moisture and extreme temperature fluctuations. Do not freeze the solution, and keep the vial sealed until ready for use to maintain sterility.

Ketorolac Trometamol Rompharm is supplied as a sterile injectable solution for intramuscular or intravenous injection. Administration is performed by a qualified healthcare professional, who selects the appropriate route, dose volume and injection site according to the patient’s clinical needs and prescribing information.

The most serious risks include gastrointestinal bleeding or ulceration, acute renal impairment, severe hypersensitivity reactions such as anaphylaxis, and cardiovascular events like myocardial infarction or stroke. Patients should be monitored for signs of bleeding, kidney dysfunction and allergic reactions, especially during prolonged or high‑dose therapy.

Ketorolac Trometamol Rompharm is contraindicated in patients with severe renal impairment, active peptic ulcer disease, known hypersensitivity to ketorolac or other NSAIDs, uncontrolled hypertension, and those with a history of serious cardiovascular events. It should also be avoided in patients receiving concurrent anticoagulant therapy unless closely monitored.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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