Product image of Ketorolaco Kabi (Ketorolac Trometamol) supplied by GNH India

Ketorolaco Kabi

Active Ingredient:
Ketorolac Trometamol
Origin:
EU

Ketorolaco Kabi (Ketorolac Trometamol)

Ketorolac Trometamol, the active ingredient in Ketorolaco Kabi, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an injectable solution for intramuscular or intravenous use. It is indicated for short‑term management of moderate to severe acute pain in adult patients.
GNH India supplies Ketorolaco Kabi as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Fresenius Kabi España S.A.U.

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Indications & Clinical Uses

  • Ketorolaco Kabi is an NSAID that provides analgesia for acute pain conditions.
  • Acute postoperative pain: Provides rapid, potent relief after surgical procedures.
  • Acute musculoskeletal pain: Reduces pain from sprains, strains, or trauma.
  • Severe dental pain: Controls intense pain following dental extractions or procedures.

How It Works

  • Ketorolac trometamol exerts its effect by non‑selectively inhibiting cyclooxygenase (COX‑1 and COX‑2) enzymes, which blocks the conversion of arachidonic acid to prostaglandins. The resulting decrease in prostaglandin synthesis diminishes inflammation, sensitization of nociceptors, and the perception of pain, delivering fast analgesic action after injection.

Side Effects

Ketorolaco Kabi may cause a range of adverse reactions.

Common Side Effects

  • Nausea or vomiting
  • Dizziness or headache
  • Injection‑site pain or erythema
  • Gastro‑intestinal discomfort
  • Mild renal function changes

Serious or Rare Side Effects

  • Gastro‑intestinal bleeding or ulceration
  • Acute renal failure or significant creatinine rise
  • Severe hypersensitivity reactions, including anaphylaxis

Precautions & Warnings

  • When using Ketorolaco Kabi, consider the following safety measures.
  • Assess renal function: Verify baseline kidney status before initiating therapy.
  • Monitor for gastrointestinal bleeding: Use the lowest effective dose and limit duration.
  • Avoid in patients with known NSAID hypersensitivity: Substitute with a non‑NSAID analgesic.
  • Caution in cardiovascular disease: Evaluate bleeding risk and avoid prolonged use.
  • Limit duration: Do not exceed 5 days of continuous therapy.
  • Store at 2-8°C: Keep refrigerated, protect from light, do not freeze.

Avoid Interactions

Ketorolaco Kabi can interact with several drug classes.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): Increased risk of serious bleeding.
  • Other NSAIDs or aspirin: Additive gastrointestinal toxicity.
  • Lithium: Heightened lithium serum concentrations.

Moderate Interactions (Monitor Closely)

  • Diuretics (especially thiazides): Potential reduction in renal clearance.
  • ACE inhibitors or ARBs: May impair renal function when combined.
  • Methotrexate: Decreased clearance leading to toxicity.

Frequently Asked Questions

Ketorolaco Kabi is an injectable NSAID used for the short‑term management of moderate to severe acute pain, such as postoperative, musculoskeletal, or dental pain, when rapid analgesia is required.

Ketorolac trometamol blocks both COX‑1 and COX‑2 enzymes, reducing the production of prostaglandins that mediate inflammation and pain. This inhibition leads to decreased sensitization of pain receptors and provides fast analgesic effects.

The specific dose and frequency are determined by the prescribing clinician based on the patient’s condition, weight, and renal function. Ketorolaco Kabi is administered by a healthcare professional via intramuscular or intravenous injection.

Safety data for ketorolac in pregnancy and lactation are limited. It is generally avoided in the third trimester and during breastfeeding unless the benefits outweigh potential risks, as advised by a qualified healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, confirming trade or institutional credentials before providing pricing, availability, shipping details, and necessary import documentation.

Ketorolaco Kabi offers potent analgesia comparable to stronger opioids for short‑term use, but it carries a higher risk of renal and gastrointestinal adverse effects than less potent NSAIDs. It is typically reserved for situations where rapid, strong pain relief is essential and the treatment duration is limited.

Ketorolaco Kabi should be stored at 2‑8 °C, protected from light, and kept in its original packaging. Do not freeze or shake the vial. If the product reaches room temperature, it should be used promptly and not re‑refrigerated.

The medication is supplied as a sterile solution for injection. It can be given intramuscularly or intravenously by a qualified healthcare professional, following aseptic technique and the dosage prescribed by the treating physician.

Serious risks include gastrointestinal bleeding or ulceration, acute renal failure, severe allergic reactions such as anaphylaxis, and increased cardiovascular events. Patients should be monitored closely for signs of these complications, especially when used with other high‑risk medications.

Ketorolaco Kabi is contraindicated in patients with known hypersensitivity to ketorolac or other NSAIDs, active gastrointestinal bleeding, severe renal impairment, and those at high risk for cardiovascular events. It should also be avoided in patients who have had recent coronary artery bypass graft surgery.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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