Product image of Ketorolaco Trometamol Normon (Ketorolac Trometamol) supplied by GNH India

Ketorolaco Trometamol Normon

Active Ingredient:
Ketorolac Trometamol
Origin:
EU

Ketorolaco Trometamol Normon (Ketorolac Trometamol)

Ketorolac Trometamol, the active ingredient in Ketorolaco Trometamol Normon, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an injectable solution for intramuscular and intravenous use. It is employed for short‑term management of moderate to severe pain in adult patients.
GNH India supplies Ketorolaco Trometamol Normon as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Laboratorios Normon, S.A.

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Indications & Clinical Uses

Ketorolac Trometamol is an NSAID indicated for acute pain conditions where rapid analgesia is required.

  • Post‑operative pain: provides effective analgesia for up to 24 hours after surgery.
  • Acute musculoskeletal pain: reduces pain intensity following injury or strain.
  • Renal colic: offers short‑term relief of severe flank pain associated with kidney stones.

How It Works

  • Ketorolac Trometamol acts as a non‑selective cyclooxygenase (COX‑1 and COX‑2) inhibitor, blocking the conversion of arachidonic acid to prostaglandins. By decreasing prostaglandin synthesis, it reduces peripheral sensitisation of nociceptors and diminishes inflammation, resulting in analgesic and anti‑inflammatory effects.

Side Effects

Adverse reactions may occur with ketorolac use.

Common Side Effects

  • Nausea or vomiting
  • Headache
  • Dizziness or vertigo
  • Injection‑site pain or erythema
  • Gastro‑intestinal discomfort
  • Elevated blood pressure

Serious or Rare Side Effects

  • Gastrointestinal ulceration or bleeding
  • Acute renal impairment or failure
  • Severe hypersensitivity reactions (e.g., anaphylaxis)
  • Cardiovascular thrombotic events (myocardial infarction, stroke)
  • Hepatic enzyme elevation or liver injury
  • Hematologic abnormalities such as thrombocytopenia

Precautions & Warnings

Ketorolac should be used with careful clinical assessment and monitoring.

  • Assess renal function: avoid in patients with severe renal impairment.
  • Monitor gastrointestinal risk: use the lowest effective dose for the shortest duration.
  • Check bleeding risk: contraindicated in active bleeding or coagulopathy.
  • Avoid in patients with known hypersensitivity to NSAIDs or aspirin.
  • Use with caution in cardiovascular disease: monitor blood pressure and signs of ischemia.
  • Store at ambient temperature: keep in the original container, protect from light and moisture.

Avoid Interactions

Ketorolac may interact with several drug classes, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of serious bleeding.
  • Other NSAIDs or COX‑2 inhibitors: additive gastrointestinal toxicity.
  • Selective serotonin reuptake inhibitors (SSRIs): heightened bleeding tendency.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: may reduce renal perfusion, especially in volume‑depleted patients.
  • Diuretics: combined use can precipitate renal impairment.
  • Lithium: NSAIDs may increase serum lithium concentrations, requiring level monitoring.

Frequently Asked Questions

Ketorolaco Trometamol Normon is an injectable NSAID used for the short‑term management of moderate to severe acute pain, such as post‑operative pain, musculoskeletal injuries, or renal colic. It provides rapid analgesia when administered intravenously or intramuscularly.

Ketorolac trometamol inhibits both COX‑1 and COX‑2 enzymes, reducing the synthesis of prostaglandins that mediate inflammation and pain. Lower prostaglandin levels decrease peripheral sensitisation of nociceptors, resulting in analgesic and anti‑inflammatory effects.

The specific dose and frequency are determined by the prescribing clinician based on the patient’s condition, weight, renal function, and overall risk profile. Standard dosing regimens are outlined in clinical guidelines, but the prescriber tailors therapy to each individual.

Safety data for ketorolac during pregnancy and lactation are limited, and the drug is generally avoided, especially in the third trimester, because of potential fetal and neonatal risks. Breastfeeding mothers should consult a healthcare professional before use.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Ketorolac provides potent analgesia comparable to moderate‑dose opioids but without the risk of respiratory depression. Compared with other NSAIDs such as ibuprofen, it has a faster onset and higher potency for short‑term use, though it carries a higher risk of renal and gastrointestinal adverse effects if used beyond recommended durations.

The product should be stored at ambient temperature, preferably below 25 °C, in its original packaging to protect from light and moisture. Vials must be kept upright, and any unused solution should be discarded according to local regulations after the recommended in‑use period.

Ketorolaco Trometamol is administered by a healthcare professional either as an intramuscular injection or an intravenous infusion. The route, rate, and volume are selected by the prescriber to achieve rapid analgesia while monitoring the patient for any adverse reactions.

Serious risks include gastrointestinal ulceration or bleeding, acute renal failure, severe hypersensitivity reactions (including anaphylaxis), and cardiovascular events such as myocardial infarction or stroke. Patients should be monitored closely for signs of these complications, especially when used at higher doses or for longer than recommended.

Ketorolaco Trometamol is contraindicated in patients with known hypersensitivity to ketorolac or other NSAIDs, active peptic ulcer disease, severe renal impairment, uncontrolled hypertension, and those with a history of cardiovascular thrombotic events. It should also be avoided in patients receiving anticoagulant therapy unless specifically directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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