Product image of Ketospray (Ketoprofen) supplied by GNH India

Ketospray

Active Ingredient:
Ketoprofen
Origin:
EU

Ketospray (Ketoprofen)

Ketoprofen, the active ingredient in Ketospray, is a nonsteroidal anti‑inflammatory drug (NSAID) presented as a topical spray for cutaneous application. It works by reducing prostaglandin synthesis, providing relief from mild to moderate musculoskeletal pain, joint inflammation, and localized soft‑tissue discomfort in adult patients.

GNH India supplies Ketospray as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory‑approved batches to meet global demand across multiple regions and therapeutic areas.

Manufacturer / TM Owner

Cyathus Exquirere Pharmaforschungsgmbh

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Indications & Clinical Uses

Ketoprofen is indicated for conditions involving inflammation and pain in the musculoskeletal system.

  • Mild to moderate musculoskeletal pain: Reduces pain and improves function in conditions such as backache or overuse injuries.
  • Arthritic joint inflammation: Alleviates swelling and discomfort associated with osteoarthritis and rheumatoid arthritis.
  • Localized soft‑tissue injuries: Provides topical relief for sprains, strains, and bruises.

How It Works

  • Ketoprofen exerts its anti‑inflammatory and analgesic effects by non‑selectively inhibiting cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes. This inhibition blocks the conversion of arachidonic acid to prostaglandins, which are mediators of inflammation, pain, and fever. Reduced prostaglandin levels diminish vascular permeability and nociceptor sensitization at the site of application. Topical delivery allows the drug to concentrate in the skin and underlying tissues while limiting systemic exposure.

Side Effects

Ketoprofen may cause adverse reactions, which are generally classified by frequency and severity.

Common Side Effects

  • Skin irritation at application site: redness, itching, or burning sensation.
  • Localized itching or rash.
  • Dryness of the skin.
  • Mild headache.

Serious or Rare Side Effects

  • Severe allergic reaction: swelling of face, lips, or throat, and difficulty breathing.
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Significant gastrointestinal bleeding (rare with topical use).

Precautions & Warnings

When using Ketospray, certain precautions should be observed to minimize risks and ensure optimal therapeutic outcomes.

  • Avoid application on broken or infected skin: limit use to intact epidermis.
  • Do not exceed recommended frequency: follow prescriber instructions for number of applications per day.
  • Monitor for signs of hypersensitivity: discontinue if rash or swelling develops.
  • Use with caution in patients with known NSAID sensitivity or asthma.
  • Keep away from eyes and mucous membranes: avoid accidental contact.
  • Store at room temperature below 25°C: keep in original container, protect from moisture and direct sunlight.

Avoid Interactions

Ketoprofen can interact with other medicines, affecting its safety or effectiveness.

Major Interactions (Avoid)

  • Concurrent systemic NSAIDs or COX‑2 inhibitors: increased risk of gastrointestinal ulceration and bleeding.
  • Anticoagulants (e.g., warfarin): potentiation of bleeding tendency.
  • Corticosteroids: heightened risk of skin ulceration and systemic adverse effects.

Moderate Interactions (Monitor Closely)

  • Diuretics (e.g., furosemide): may reduce renal clearance of ketoprofen.
  • ACE inhibitors or ARBs: possible reduction in renal function, especially in dehydrated patients.
  • Lithium: NSAIDs may increase lithium serum levels.

Frequently Asked Questions

Ketospray is a cutaneous formulation of ketoprofen that is applied to the skin to relieve mild to moderate musculoskeletal pain, joint inflammation associated with arthritis, and localized soft‑tissue injuries such as sprains or bruises. It provides targeted anti‑inflammatory and analgesic effects at the site of application.

Ketoprofen works by non‑selectively inhibiting the cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, which are essential for converting arachidonic acid into prostaglandins. By reducing prostaglandin production, ketoprofen diminishes inflammation, pain signaling, and fever, leading to symptom relief where it is applied.

The appropriate amount of Ketospray to apply, as well as the frequency of application, is determined by the prescribing healthcare professional based on the individual’s condition, severity, and treatment response. Patients should follow the prescriber’s instructions and not exceed the recommended number of applications.

Safety data for topical ketoprofen during pregnancy and lactation are limited. Because the product’s pregnancy category is unknown, it should only be used if the potential benefit outweighs any possible risk, and only after consultation with a qualified healthcare provider.

To place an order, submit an enquiry on the Ketospray product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Ketospray contains ketoprofen, a potent NSAID with both COX‑1 and COX‑2 inhibition, offering strong anti‑inflammatory and analgesic activity. Compared with some other topical NSAIDs that may have selective COX‑2 inhibition, ketoprofen provides broader prostaglandin suppression, which can translate into effective relief for a wider range of inflammatory conditions.

Ketospray should be stored at room temperature below 25 °C, in its original packaging, protected from moisture and direct sunlight. Keep the container tightly closed when not in use, and avoid exposing the product to extreme temperatures or humidity to maintain its stability and efficacy.

The spray is applied to clean, intact skin at the affected area. The prescriber will specify the number of sprays per application and the maximum frequency (often 2‑4 times daily). After spraying, allow the medication to dry before covering the area with clothing or bandages.

Serious adverse reactions, although rare, include severe allergic responses such as facial swelling, difficulty breathing, or anaphylaxis, as well as life‑threatening skin conditions like Stevens‑Johnson syndrome or toxic epidermal necrolysis. Immediate medical attention is required if any of these symptoms develop.

Ketospray should be avoided in individuals with known hypersensitivity to ketoprofen or any other NSAIDs, in patients with active skin infections or open wounds at the intended site of application, and in those who have experienced severe cutaneous adverse reactions to NSAIDs in the past.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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