Product image of Ketospray (Ketoprofen) supplied by GNH India

Ketospray

Active Ingredient:
Ketoprofen
Origin:
EU

Ketospray (Ketoprofen)

Ketoprofen, the active ingredient in Ketospray, is a nonsteroidal anti-inflammatory drug presented as a topical spray for topical use. It relieves pain and inflammation in musculoskeletal conditions.

GNH India supplies Ketospray as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Leram Pharmaceuticals S.R.O.

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Indications & Clinical Uses

Ketoprofen is an NSAID that acts on the cyclo‑oxygenase pathway to reduce inflammation and pain.

  • Osteoarthritis of the knee: provides local pain relief and improves joint function.
  • Acute muscle sprain or strain: diminishes swelling and eases movement.
  • Tendinitis and bursitis: reduces localized inflammation and discomfort.
  • Rheumatoid arthritis flare‑ups (topical adjunct): helps control peripheral joint pain when used with systemic therapy.

How It Works

  • Ketoprofen inhibits cyclo‑oxygenase‑1 and cyclo‑oxygenase‑2 enzymes, decreasing the synthesis of prostaglandins that mediate inflammation, pain, and fever. By limiting prostaglandin production at the site of application, it reduces vascular permeability, edema, and nociceptor sensitisation, resulting in analgesic and anti‑inflammatory effects.

Side Effects

Ketoprofen may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Skin irritation at the application site: redness or itching.
  • Localized burning or stinging sensation.
  • Dryness or peeling of the treated skin.
  • Mild headache.
  • Gastro‑intestinal discomfort (rare with topical use).

Serious or Rare Side Effects

  • Severe allergic reaction: hives, swelling, or difficulty breathing.
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Significant liver enzyme elevation.
  • Renal function impairment in susceptible patients.

Precautions & Warnings

Ketoprofen should be used with awareness of its safety profile and patient‑specific factors.

  • Contraindication: avoid in patients with known hypersensitivity to ketoprofen or other NSAIDs.
  • Caution: use carefully in individuals with a history of asthma, urticaria, or allergic reactions to NSAIDs.
  • Pregnancy: not recommended during the third trimester; consult a healthcare professional.
  • Breastfeeding: discuss risks with a physician, as small amounts may be excreted in milk.
  • Drug interactions: review concomitant medications for potential NSAID‑related risks.
  • Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Ketoprofen can affect the safety or efficacy of several other medicines.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of serious bleeding.
  • Other NSAIDs or COX‑2 inhibitors: heightened gastrointestinal toxicity.
  • High‑dose aspirin: additive renal and gastrointestinal adverse effects.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: possible reduction in antihypertensive effect and renal function changes.
  • Diuretics: may enhance renal impairment risk.
  • Lithium: NSAIDs can raise lithium serum concentrations.

Frequently Asked Questions

Ketospray contains ketoprofen, an NSAID formulated as a topical spray. It is used to relieve pain and inflammation associated with osteoarthritis of the knee, acute muscle sprains or strains, tendonitis, bursitis, and as an adjunct for peripheral joint pain in rheumatoid arthritis flare‑ups.

Ketoprofen blocks the cyclo‑oxygenase‑1 and cyclo‑oxygenase‑2 enzymes, which are essential for prostaglandin production. By lowering prostaglandin levels at the site of application, it reduces vascular leakage, swelling, and the activation of pain‑sensing nerves, providing analgesic and anti‑inflammatory effects.

The specific dose and frequency of Ketospray are determined by the prescribing clinician based on the patient’s condition, severity of symptoms, and treatment goals. The prescriber will provide detailed instructions on how much spray to apply and how often.

Ketospray is not recommended during the third trimester of pregnancy because NSAIDs may affect fetal cardiovascular development. For breastfeeding mothers, the potential for ketoprofen to pass into breast milk exists, so a healthcare professional should evaluate the risk‑benefit balance before use.

To request Ketospray, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain needs) and necessary import documentation.

Ketospray delivers ketoprofen directly to the skin, offering targeted pain relief with lower systemic exposure compared with oral NSAIDs such as ibuprofen or diclofenac. This topical route can reduce the risk of gastrointestinal side effects while still providing effective anti‑inflammatory action for localized conditions.

Ketospray should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed when not in use.

Ketospray is applied topically to the affected area. The prescriber will advise the amount to spray, typically a measured number of pumps, and the frequency (e.g., two to three times daily). The skin should be clean and dry before application, and hands should be washed after use.

Serious risks include severe allergic reactions such as anaphylaxis, Stevens‑Johnson syndrome or toxic epidermal necrolysis, and significant liver or kidney impairment in susceptible individuals. Any signs of widespread rash, swelling, breathing difficulty, or unusual fatigue should prompt immediate medical attention.

Ketospray should not be used by individuals with known hypersensitivity to ketoprofen or other NSAIDs, those who have experienced asthma, urticaria, or allergic reactions after NSAID exposure, and patients in the third trimester of pregnancy. Consultation with a healthcare professional is essential for anyone with existing liver, kidney, or cardiovascular disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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