Product image of Ketosteril (L-Lysine Acetate, L-Tryptophan, L-Histidine, L-Threonine, L-Tyrosine, Keto-Isoleucine Calcium, Keto-) supplied by GNH India

Ketosteril

Active Ingredient:
L-Lysine Acetate, L-Tryptophan, L-Histidine, L-Threonine, L-Tyrosine, Keto-Isoleucine Calcium, Keto-
Origin:
EU

Ketosteril (L-Lysine Acetate, L-Tryptophan, L-Histidine, L-Threonine, L-Tyrosine, Keto-Isoleucine Calcium, Keto-)

Ketosteril, the active ingredient in Ketosteril, is an amino acid supplement presented as an oral dosage form for oral use. It is used to support protein metabolism and reduce nitrogen waste in patients with chronic kidney disease who require dietary protein restriction.

GNH India supplies Ketosteril as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals and pharmacies worldwide.

Manufacturer / TM Owner

Fresenius Kabi Deutschland Gmbh

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Indications & Clinical Uses

Ketosteril is employed in the management of renal nutrition disorders, particularly in chronic kidney disease patients following a low‑protein diet.

  • Chronic kidney disease with dietary protein restriction: helps maintain nitrogen balance and supports essential amino acid synthesis.
  • Pre‑dialysis CKD patients: assists in reducing uremic toxin accumulation.
  • Patients on maintenance dialysis: provides keto‑analogues that can be transaminated to essential amino acids, aiding overall protein nutrition.

How It Works

  • Ketosteril supplies keto‑analogues of essential amino acids that are transaminated in the body to form the corresponding amino acids. This process reduces the production of nitrogenous waste, lowers urea generation, and supports protein synthesis while minimizing the metabolic burden on compromised kidneys in chronic kidney disease.

Side Effects

Ketosteril may cause adverse reactions, most of which are mild and transient.

Common Side Effects

  • Nausea: mild to moderate discomfort in the stomach.
  • Vomiting: occasional episodes, usually early in therapy.
  • Abdominal discomfort: cramping or pain in the gastrointestinal tract.
  • Loss of appetite: reduced desire to eat.
  • Diarrhoea or constipation: changes in bowel habits.
  • Headache: mild to moderate intensity.

Serious or Rare Side Effects

  • Severe metabolic acidosis: marked acid‑base imbalance requiring medical attention.
  • Hyperkalemia: elevated potassium levels that may affect cardiac function.
  • Allergic reactions: rash, itching, or swelling of the face and throat.
  • Hepatic dysfunction: abnormal liver enzyme elevations.
  • Severe hyperphosphatemia: high phosphate levels that can worsen renal disease.
  • Anaphylaxis: rare, life‑threatening hypersensitivity reaction.

Precautions & Warnings

Ketosteril should be used with careful clinical monitoring.

  • Renal function monitoring: assess serum urea, creatinine, and electrolytes regularly.
  • Electrolyte balance: watch for hyperkalemia and hyperphosphatemia, especially in dialysis patients.
  • Pregnancy and lactation: avoid unless clearly needed; safety data are limited.
  • Liver disease: use cautiously in patients with hepatic impairment.
  • Concomitant medications: review all drugs for potential interactions.
  • Store at ambient temperature: keep below 25 °C, in the original container, protected from moisture and direct sunlight.

Avoid Interactions

Ketosteril may interact with several medicines and dietary factors.

Major Interactions (Avoid)

  • High‑protein diets or supplements: can diminish the intended nitrogen‑sparing effect.
  • Phosphate binders containing calcium: may increase calcium load when combined.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: monitor potassium and renal function.
  • Loop or thiazide diuretics: watch for electrolyte disturbances.
  • NSAIDs: may exacerbate renal impairment.
  • Oral iron preparations: may affect absorption of amino acid analogues.
  • Vitamin D analogues: monitor calcium and phosphate levels.

Frequently Asked Questions

Ketosteril is a renal nutrition supplement prescribed for patients with chronic kidney disease who need a low‑protein diet. It provides keto‑analogues of essential amino acids that help maintain nitrogen balance and support protein synthesis while reducing the generation of waste products that the kidneys would otherwise need to excrete.

The active component of Ketosteril consists of keto‑analogues of essential amino acids. These compounds are transaminated in the body to become the corresponding amino acids, thereby supplying the necessary building blocks for protein synthesis without adding extra nitrogen, which helps lower urea and other nitrogenous waste in patients with impaired kidney function.

The dosage of Ketosteril is individualized by the prescribing clinician based on the patient’s stage of kidney disease, dietary protein allowance, and overall clinical condition. Healthcare professionals determine the appropriate amount and frequency to achieve optimal nitrogen balance while avoiding excess intake.

Safety data for Ketosteril in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the possible risk to the fetus or infant, and this decision must be made by a qualified healthcare provider after a thorough risk‑benefit assessment.

To order Ketosteril, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Ketosteril is distinguished by its blend of keto‑analogues that are directly transaminated to essential amino acids, offering a nitrogen‑sparing effect not always present in standard amino‑acid supplements. Compared with plain protein supplements, Ketosteril reduces urea generation while still supporting protein metabolism, making it a preferred option for patients on strict protein restriction.

Ketosteril should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture, heat, and direct sunlight. Ensure the container is tightly closed to maintain stability throughout its shelf life.

Ketosteril is taken orally, usually with meals to improve tolerance and absorption. The exact dosing schedule, including the number of tablets or sachets per day, is determined by the prescribing physician based on the patient’s nutritional needs and renal function.

Serious risks, though uncommon, include severe metabolic acidosis, hyperkalemia, significant allergic reactions such as rash or anaphylaxis, and hepatic dysfunction. Patients should be monitored regularly for electrolyte disturbances and liver function, and any signs of severe adverse reactions require immediate medical attention.

Ketosteril is contraindicated in patients with known hypersensitivity to any of its components. It should also be avoided in individuals with uncontrolled hyperkalemia, severe liver disease, or those who are not following a prescribed low‑protein diet, unless a healthcare professional determines that the benefits outweigh the risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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