Product image of Ketosteril (L-Lysine Acetate, L-Tryptophan, L-Histidine, L-Threonine, L-Tyrosine, Keto-Isoleucine Calcium, Keto-) supplied by GNH India

Ketosteril

Active Ingredient:
L-Lysine Acetate, L-Tryptophan, L-Histidine, L-Threonine, L-Tyrosine, Keto-Isoleucine Calcium, Keto-
Origin:
EU

Ketosteril (L-Lysine Acetate, L-Tryptophan, L-Histidine, L-Threonine, L-Tyrosine, Keto-Isoleucine Calcium, Keto-)

L‑Lysine acetate, L‑tryptophan, L‑histidine, L‑threonine, L‑tyrosine, keto‑isoleucine calcium and related keto‑analogues, the active ingredients in Ketosteril, are a ketoanalog supplement presented as an oral formulation for renal nutrition support use. It is employed to manage chronic kidney disease and related protein‑restriction needs in patients requiring dietary management.

GNH India supplies Ketosteril as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres and pharmacies worldwide. The product is manufactured in the European Union under strict GMP standards, ensuring consistent quality for renal nutrition therapy.

Manufacturer / TM Owner

Fresenius Kabi Ab

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Indications & Clinical Uses

  • Ketosteril is used in renal nutrition support to address protein‑restriction and metabolic needs in chronic kidney disease.
  • Chronic kidney disease: helps reduce nitrogen waste and supports protein metabolism.
  • Renal failure: provides essential amino acid precursors while limiting dietary protein load.
  • Dietary protein restriction in renal patients: supplies keto‑analogues that are converted to essential amino acids, allowing lower protein intake.

How It Works

  • Ketosteril contains keto‑analogues of essential amino acids that are transaminated in the body to form the corresponding essential amino acids. By supplying these precursors, the product reduces the need for dietary protein, thereby decreasing nitrogenous waste production and uremic toxin accumulation. This supports protein synthesis and improves nitrogen balance in patients with reduced renal function.

Side Effects

Ketosteril may be associated with several adverse reactions, ranging from mild to serious.

Common Side Effects

  • Nausea.
  • Vomiting.
  • Loss of appetite.

Serious or Rare Side Effects

  • Hyperkalemia.
  • Severe allergic reactions such as rash or angioedema.
  • Metabolic acidosis.

Precautions & Warnings

  • When prescribing Ketosteril, clinicians should observe several precautionary measures to ensure patient safety.
  • Monitor renal function: regular assessment of serum creatinine and urea.
  • Adjust dose in severe renal impairment: dose may need reduction.
  • Avoid in known hypersensitivity: discontinue if allergic signs appear.
  • Caution with potassium‑rich diets: risk of hyperkalemia.
  • Use under medical supervision: only for patients with prescribed protein restriction.
  • Store at below 25°C: keep in original container, protect from moisture.

Avoid Interactions

Ketosteril can interact with other medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • High‑protein nutritional supplements: may negate the nitrogen‑sparing effect.
  • Potassium‑sparing diuretics: increase risk of hyperkalemia.
  • ACE inhibitors or ARBs: may exacerbate potassium elevation.

Moderate Interactions (Monitor Closely)

  • Phosphate binders: may affect keto‑analogue absorption.
  • Antacids: can alter gastric pH and conversion efficiency.
  • Loop diuretics: require monitoring of electrolyte balance.

Frequently Asked Questions

Ketosteril is prescribed as a renal nutrition support to help patients with chronic kidney disease or renal failure who require dietary protein restriction. It supplies keto‑analogues of essential amino acids, allowing reduced protein intake while maintaining nutritional balance.

The keto‑analogues in Ketosteril are transaminated in the body to become essential amino acids. This process provides the building blocks for protein synthesis without adding nitrogen load, thereby decreasing waste products that the kidneys would otherwise need to excrete.

The dosage of Ketosteril is individualized by the prescribing clinician based on the patient’s renal function, nutritional status, and protein‑restriction goals. Specific dosing regimens are not publicly disclosed and should follow the prescriber’s instructions.

Safety data for Ketosteril in pregnancy and lactation are limited. It should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant, and only under direct medical supervision.

To request Ketosteril, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Ketosteril differs from standard amino‑acid supplements by providing keto‑analogues rather than the amino acids themselves. This allows patients to limit dietary protein while still receiving essential amino‑acid precursors, a strategy that can better control nitrogen waste compared with plain protein or amino‑acid formulations.

Ketosteril should be stored at temperatures below 25 °C, in its original packaging, and protected from moisture and direct sunlight. Keeping the product in a dry, cool environment helps maintain its stability and potency.

Ketosteril is taken orally, usually with a glass of water and often with meals to improve absorption. The exact timing and frequency are determined by the prescribing clinician based on the individual treatment plan.

The most serious adverse events reported with Ketosteril include hyperkalemia, severe allergic reactions such as rash or angioedema, and metabolic acidosis. Patients should be monitored regularly for signs of these conditions, especially if they have pre‑existing electrolyte disturbances.

Ketosteril is contraindicated in patients with known hypersensitivity to any of its components, those with uncontrolled hyperkalemia, or individuals for whom a high‑protein diet is medically required. It should also be avoided in patients with severe metabolic acidosis unless closely supervised by a specialist.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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