Product image of Ketosteril (L-Lysine Acetate, L-Tryptophan, L-Histidine, L-Threonine, L-Tyrosine, Keto-Isoleucine Calcium, Keto-) supplied by GNH India

Ketosteril

Active Ingredient:
L-Lysine Acetate, L-Tryptophan, L-Histidine, L-Threonine, L-Tyrosine, Keto-Isoleucine Calcium, Keto-
Origin:
EU

Ketosteril (L-Lysine Acetate, L-Tryptophan, L-Histidine, L-Threonine, L-Tyrosine, Keto-Isoleucine Calcium, Keto-)

Keto‑analogues of essential amino acids, the active ingredient in Ketosteril, is an amino acid supplement presented as an oral supplement for oral use. It supports renal function in patients with chronic kidney disease and those on low‑protein diets.

GNH India supplies Ketosteril as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, dialysis units and pharmacies worldwide, ensuring quality‑assured products for renal care programs. The company adheres to stringent regulatory standards and provides reliable, timely logistics for global distribution.

Manufacturer / TM Owner

Fresenius Kabi France S.A.S.

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Indications & Clinical Uses

Ketosteril is used to support renal function and protein metabolism in chronic kidney disease and related conditions.

  • Chronic kidney disease: helps reduce nitrogen load and supports essential amino acid synthesis in patients with reduced renal function.
  • Renal failure: provides keto‑analogues that are converted to essential amino acids, aiding protein metabolism when kidney clearance is impaired.
  • Low‑protein diet supplementation: supplies necessary amino acid precursors to maintain nutrition while limiting dietary protein intake.

How It Works

  • Ketosteril supplies keto‑analogues of essential amino acids such as L‑lysine acetate, L‑tryptophan, L‑histidine, L‑threonine, L‑tyrosine, and calcium‑bound keto‑isoleucine. In the body these analogues undergo transamination using nitrogen from non‑essential amino acids, forming the corresponding essential amino acids. This process reduces the amount of nitrogen that must be excreted by the kidneys, thereby decreasing uremic toxin accumulation and supporting protein synthesis in patients with renal insufficiency.

Side Effects

Ketosteril may be associated with adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Nausea: mild stomach discomfort occurring after oral intake.
  • Vomiting: occasional expulsion of stomach contents.
  • Diarrhea: loose stools, generally transient.
  • Constipation: reduced bowel movements.
  • Headache: mild cranial pain.
  • Metallic taste: temporary alteration in taste perception.

Serious or Rare Side Effects

  • Allergic reaction: rash, itching, swelling, or anaphylaxis.
  • Hyperkalemia: elevated blood potassium levels.
  • Metabolic acidosis: significant acid‑base imbalance.
  • Hepatic dysfunction: abnormal liver enzyme elevations.
  • Severe skin rash: Stevens‑Johnson‑like reactions.
  • Hypophosphatemia: low blood phosphate levels.

Precautions & Warnings

When using Ketosteril, certain precautions should be observed to ensure safety and effectiveness.

  • Renal function monitoring: assess serum urea and creatinine regularly.
  • Protein intake: coordinate with low‑protein diet to avoid excess.
  • Electrolyte balance: monitor potassium and phosphate levels.
  • Pregnancy and lactation: use only if benefits outweigh risks.
  • Drug interactions: review concomitant medications for nitrogen‑related effects.
  • Store below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Ketosteril can interact with other medicines; awareness of the type of interaction helps manage patient safety.

Major Interactions (Avoid)

  • High protein supplements: may counteract the nitrogen‑sparing effect.
  • Lithium: altered renal clearance may increase toxicity.
  • Nephrotoxic drugs: combined use may worsen renal function.

Moderate Interactions (Monitor Closely)

  • Phosphate binders: may affect absorption of keto‑analogues.
  • Potassium‑sparing diuretics: monitor serum potassium.
  • Antacids containing aluminum or magnesium: may reduce bioavailability.

Frequently Asked Questions

Ketosteril is an oral amino acid supplement used to support patients with chronic kidney disease, renal failure, or those following a low‑protein diet. It provides keto‑analogues that help reduce nitrogen burden and maintain essential amino acid levels, aiding overall protein metabolism and nutritional status.

The active ingredient consists of keto‑analogues of essential amino acids. After ingestion, these analogues undergo transamination, using nitrogen from non‑essential amino acids to form the corresponding essential amino acids. This nitrogen‑sparing process lowers the amount of waste nitrogen the kidneys must excrete, helping to manage uremic load in renal impairment.

The dosage of Ketosteril is individualized and set by the prescribing healthcare professional based on the patient’s renal function, dietary protein restriction, and overall clinical condition. Patients should follow the prescriber’s instructions and not adjust the dose without medical guidance.

Safety data for Ketosteril in pregnancy and lactation are limited. It should only be used if the potential benefits to the mother outweigh any possible risks to the fetus or infant, and this decision must be made by a qualified healthcare provider.

To order Ketosteril, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide. After the enquiry, the sales team will verify trade or institutional credentials, then provide pricing, availability, shipping details, and any necessary import documentation.

Ketosteril differs from standard essential amino acid supplements by providing keto‑analogues that require transamination, which reduces nitrogen load. Compared with plain protein restriction, Ketosteril allows patients to maintain nutritional status while limiting waste nitrogen. It is generally considered more effective than simple low‑protein diets alone for preserving essential amino acid balance.

Ketosteril should be stored at temperatures below 25 °C, in its original packaging, and protected from moisture. Keep the product away from direct sunlight and excessive heat to maintain stability and potency throughout its shelf life.

Ketosteril is taken orally, usually with a glass of water. It is often recommended to be taken with meals to improve tolerance and absorption, but patients should follow the specific instructions provided by their healthcare professional.

Serious risks include allergic reactions such as rash or anaphylaxis, hyperkalemia (elevated potassium), metabolic acidosis, hepatic dysfunction, severe skin reactions, and hypophosphatemia. Patients should be monitored for these events, and any concerning symptoms should be reported to a healthcare provider promptly.

Ketosteril should be avoided in individuals with known hypersensitivity to any of its components, severe liver disease, uncontrolled hyperkalemia, or those for whom a low‑protein diet is contraindicated. Additionally, patients with certain metabolic disorders should consult their physician before starting therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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