Product image of Ketosteril (L-Lysine Acetate, L-Tryptophan, L-Histidine, L-Threonine, L-Tyrosine, Keto-Isoleucine Calcium, Keto-) supplied by GNH India

Ketosteril

Active Ingredient:
L-Lysine Acetate, L-Tryptophan, L-Histidine, L-Threonine, L-Tyrosine, Keto-Isoleucine Calcium, Keto-
Origin:
EU

Ketosteril (L-Lysine Acetate, L-Tryptophan, L-Histidine, L-Threonine, L-Tyrosine, Keto-Isoleucine Calcium, Keto-)

L‑Lysine acetate, L‑tryptophan, L‑histidine, L‑threonine, L‑tyrosine, keto‑isoleucine calcium and other keto‑analogues, the active ingredients in Ketosteril, are an amino acid supplement presented as an oral formulation for oral use. It supports patients with chronic kidney disease, renal failure and those who require dietary protein restriction.
GNH India supplies Ketosteril as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Fresenius Kabi Italia S.R.L.

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Indications & Clinical Uses

Ketosteril is used in renal‑related conditions to provide essential amino acids while limiting nitrogen waste.

  • Chronic kidney disease: helps reduce nitrogen waste and supports protein metabolism.
  • Renal failure: aids in maintaining nutritional status during low‑protein diets.
  • Dietary protein restriction in impaired renal function: supplies keto‑analogues that are transaminated to essential amino acids, reducing accumulation of waste products.

How It Works

  • Ketosteril supplies keto‑analogues of essential amino acids that are transaminated in the body to form the corresponding essential amino acids. This process reduces the production of nitrogenous waste, lowers urea generation, and supports protein metabolism in patients with reduced renal clearance, helping to maintain nutritional balance while limiting nitrogen load.

Side Effects

Ketosteril is generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Nausea
  • Vomiting
  • Loss of appetite
  • Abdominal discomfort
  • Mild headache
  • Metallic taste in the mouth

Serious or Rare Side Effects

  • Hyperkalemia
  • Metabolic acidosis
  • Allergic reactions such as rash or angioedema
  • Hepatic dysfunction
  • Severe electrolyte imbalance
  • Anaphylactic shock

Precautions & Warnings

Ketosteril should be used with careful monitoring in specific clinical situations.

  • Renal function monitoring: assess serum creatinine and urea regularly.
  • Electrolyte balance: check potassium, sodium and phosphate levels.
  • Protein intake adjustment: coordinate with dietitian to ensure appropriate low‑protein diet.
  • Pregnancy safety: use only if clearly needed, as safety data are limited.
  • Pediatric use: prescribe only when benefits outweigh risks and under specialist supervision.
  • Store at ambient temperature: keep in the original pack, protect from moisture and light.

Avoid Interactions

Ketosteril may interact with other medicines and supplements that affect renal function or electrolyte balance.

Major Interactions (Avoid)

  • High‑protein diet supplements: may counteract the intended nitrogen‑sparing effect.
  • Lithium: increased risk of lithium toxicity.
  • ACE inhibitors: potential for additive hyperkalemia.
  • Diuretics: may exacerbate electrolyte disturbances.

Moderate Interactions (Monitor Closely)

  • NSAIDs: can impair renal function further.
  • Vitamin D analogues: monitor calcium and phosphate levels.
  • Calcium supplements: watch for hypercalcemia.
  • Oral potassium binders: adjust potassium monitoring.

Frequently Asked Questions

Ketosteril is prescribed for patients with chronic kidney disease, renal failure, or those who need a low‑protein diet due to impaired renal function. It provides keto‑analogues of essential amino acids that help maintain nutritional status while reducing nitrogen waste.

The keto‑analogues in Ketosteril are transaminated in the body to become essential amino acids. This conversion supplies needed proteins without adding nitrogen load, thereby lowering urea production and supporting protein metabolism in patients with reduced kidney function.

The dose of Ketosteril is individualized by the prescribing clinician based on the patient’s renal function, dietary protein restriction, and overall nutritional needs. No standard dosing regimen is provided here; the prescriber determines the appropriate amount.

Safety data for Ketosteril in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To order Ketosteril, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and import documentation.

Ketosteril contains a broad spectrum of keto‑analogues that are transaminated to essential amino acids, offering a comprehensive approach to nitrogen‑sparing therapy. Compared with single‑component supplements, it may provide more balanced amino‑acid provision, but the choice depends on individual patient needs and physician preference.

Ketosteril should be stored at ambient temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the container tightly closed and avoid exposure to extreme heat or humidity.

Ketosteril is taken orally, usually with meals as directed by the prescribing clinician. The tablets or powder are swallowed with water, and the dosing schedule is tailored to the patient’s nutritional plan and renal status.

Serious risks include hyperkalemia, metabolic acidosis, severe electrolyte imbalances, allergic reactions such as rash or angioedema, hepatic dysfunction, and rare cases of anaphylaxis. Patients should be monitored regularly for these potential events.

Ketosteril should be avoided in patients with known hypersensitivity to any of its components, those with uncontrolled hyperkalemia, severe hepatic impairment, or when a high‑protein diet is required for other medical conditions. Contra‑indications must be assessed by a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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