Ketosteril (L-Lysine Acetate, L-Tryptophan, L-Histidine, L-Threonine, L-Tyrosine, Keto-Isoleucine Calcium, Keto-)

Ketosteril is used as a keto‑analogue supplement to manage nitrogen balance in renal‑related conditions.

• Chronic kidney disease: helps reduce nitrogen waste and supports essential amino acid intake while patients follow a low‑protein diet.
• End‑stage renal disease on dialysis: provides necessary amino acids without adding excess nitrogen load.
• Pre‑transplant patients: improves nutritional status before transplantation, aiding recovery and graft outcomes.

• Ketosteril contains keto‑analogues of essential amino acids that are transaminated in the body to form the corresponding amino acids. By supplying these precursors, the product reduces the need for dietary protein, thereby decreasing nitrogenous waste production and helping maintain metabolic balance in patients with impaired renal function.

Ketosteril may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

• Nausea
• Vomiting
• Loss of appetite
• Abdominal discomfort
• Mild headache
• Dizziness

Serious or Rare Side Effects

• Hyperkalemia
• Metabolic acidosis
• Allergic reactions such as rash or itching
• Severe gastrointestinal upset
• Hepatic dysfunction
• Significant electrolyte imbalance

When using Ketosteril, several safety considerations should be observed.

• Monitor renal function: adjust use based on eGFR and disease stage.
• Assess electrolyte levels: watch for potassium and phosphorus abnormalities.
• Evaluate nutritional status: ensure adherence to a low‑protein diet.
• Avoid in hyperammonemia: contraindicated in patients with elevated ammonia.
• Use with caution in pregnancy: limited safety data, consult a physician.
• Store at room temperature: keep in the original container, protect from moisture and light.

Ketosteril may interact with other medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

• High‑protein supplements: may negate the nitrogen‑sparing effect.
• Potassium‑sparing diuretics: increase risk of hyperkalemia.
• ACE inhibitors or ARBs: may exacerbate potassium retention.

Moderate Interactions (Monitor Closely)

• Antacids containing aluminum or magnesium: can affect absorption.
• Phosphate binders: may reduce the product's efficacy.
• Diuretics: potential electrolyte shifts requiring monitoring.