Product image of Ketosteril (L-Lysine Acetate, L-Tryptophan, L-Histidine, L-Threonine, L-Tyrosine, Keto-Isoleucine Calcium, Keto-) supplied by GNH India

Ketosteril

Active Ingredient:
L-Lysine Acetate, L-Tryptophan, L-Histidine, L-Threonine, L-Tyrosine, Keto-Isoleucine Calcium, Keto-
Origin:
EU

Ketosteril (L-Lysine Acetate, L-Tryptophan, L-Histidine, L-Threonine, L-Tyrosine, Keto-Isoleucine Calcium, Keto-)

Ketosteril, the active ingredient in Ketosteril, is a amino acid keto analogue presented as an oral formulation for oral use. It is used to support renal nutrition in patients with chronic kidney disease or renal failure who are on low‑protein diets, helping to reduce nitrogen waste and maintain protein metabolism.

GNH India supplies Ketosteril as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, clinics and pharmacies worldwide, with a focus on quality assurance and regulatory compliance.

Manufacturer / TM Owner

Fresenius Kabi Pharma Portugal, Lda.

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Indications & Clinical Uses

Ketosteril is used in renal nutrition to support patients requiring low‑protein dietary management.

  • Chronic kidney disease: helps reduce nitrogen accumulation and supports protein synthesis in patients with reduced renal function.
  • Renal failure: provides keto analogues that are transaminated to essential amino acids, aiding nutritional status.
  • Low‑protein diet support: supplies essential amino acid precursors, allowing maintenance of nitrogen balance while limiting protein intake.

How It Works

  • Ketosteril supplies keto analogues of essential amino acids such as keto‑isoleucine, keto‑leucine, and others, which are transaminated in the liver to form the corresponding amino acids. By providing these nitrogen‑free precursors, the product reduces the need for dietary protein, decreasing nitrogenous waste generation and helping preserve renal function while supporting protein metabolism. The transamination process utilizes existing nitrogen pools, thereby minimizing additional nitrogen load on the kidneys.

Side Effects

Ketosteril may be associated with several adverse reactions, which are categorized by frequency.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Vomiting: occasional episodes.
  • Diarrhea: loose stools.
  • Headache: transient.
  • Metallic taste: altered taste perception.

Serious or Rare Side Effects

  • Hyperkalemia: elevated potassium levels.
  • Metabolic acidosis: significant acid‑base disturbance.
  • Allergic reactions: rash, itching, or swelling.
  • Hepatic dysfunction: abnormal liver enzymes.

Precautions & Warnings

When prescribing Ketosteril, clinicians should consider several precautionary measures to ensure patient safety.

  • Renal function monitoring: assess serum creatinine and urea regularly.
  • Electrolyte balance: watch potassium and phosphorus levels.
  • Protein intake assessment: coordinate with dietitian to maintain appropriate low‑protein diet.
  • Pregnancy and lactation: use only if benefits outweigh risks, as data are limited.
  • Drug interactions: review concomitant medications that affect nitrogen metabolism.
  • Store at ambient temperature: keep below 25 °C in original packaging, protect from moisture.

Avoid Interactions

Ketosteril can interact with other medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • High‑dose potassium supplements: may exacerbate hyperkalemia.
  • ACE inhibitors or ARBs: combined effect on potassium and renal function.

Moderate Interactions (Monitor Closely)

  • Sodium bicarbonate: may alter acid‑base balance.
  • Diuretics: affect electrolyte status.
  • Protein‑containing nutritional supplements: could reduce the intended low‑protein effect.

Frequently Asked Questions

Ketosteril is a prescription renal nutrition supplement used to support patients with chronic kidney disease, renal failure, or those on a low‑protein diet. It provides keto analogues of essential amino acids, helping to maintain nitrogen balance and protein metabolism while reducing the dietary protein burden on compromised kidneys.

Ketosteril delivers nitrogen‑free keto analogues of essential amino acids. These analogues are transaminated in the liver to become the corresponding amino acids, supplying the body with needed building blocks without adding extra nitrogen. This reduces nitrogenous waste production, supporting renal function and overall protein metabolism in patients with reduced kidney capacity.

The dosage of Ketosteril is individualized and must be prescribed by a qualified healthcare professional. The prescriber determines the appropriate amount based on the patient’s renal function, dietary protein restriction, and overall nutritional needs.

Safety data for Ketosteril in pregnancy and lactation are limited. It should only be used if the potential benefits to the mother outweigh any possible risks to the fetus or infant, and the decision must be made by the treating physician.

To order Ketosteril, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide. After submission, the sales team will verify trade or institutional credentials and respond with pricing, availability, shipping details (including any cold‑chain requirements), and import documentation.

Ketosteril differs from standard amino‑acid supplements by providing keto analogues that are nitrogen‑free, allowing patients to limit dietary protein while still receiving essential amino acids. This can result in lower nitrogen waste compared with conventional protein‑based supplements, making it particularly useful for patients on strict low‑protein regimens.

Ketosteril should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture, and avoid exposure to direct sunlight. No refrigeration is required for this oral formulation.

Ketosteril is administered orally, typically as tablets or powder for suspension, as directed by the prescribing physician. It is taken with meals or as advised by a dietitian to align with the patient’s low‑protein dietary plan.

The most serious adverse events to monitor include hyperkalemia (elevated potassium levels), metabolic acidosis, and severe allergic reactions such as rash, itching, or swelling. Prompt medical evaluation is required if any of these symptoms occur.

Ketosteril is contraindicated in patients with known hypersensitivity to any of its components. Caution is advised for individuals with uncontrolled hyperkalemia, severe liver disease, or those taking high‑dose potassium supplements. Pregnant or breastfeeding women should only use it under strict medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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