Product image of Ketosteril (L-Lysine Acetate, L-Tryptophan, L-Histidine, L-Threonine, L-Tyrosine, Keto-Isoleucine Calcium, Keto-) supplied by GNH India

Ketosteril

Active Ingredient:
L-Lysine Acetate, L-Tryptophan, L-Histidine, L-Threonine, L-Tyrosine, Keto-Isoleucine Calcium, Keto-
Origin:
EU

Ketosteril (L-Lysine Acetate, L-Tryptophan, L-Histidine, L-Threonine, L-Tyrosine, Keto-Isoleucine Calcium, Keto-)

L‑Lysine acetate, L‑tryptophan, L‑histidine, L‑threonine, L‑tyrosine, keto‑isoleucine calcium and other keto‑analogues, the active ingredients in Ketosteril, are keto‑analogues of essential amino acids presented as an oral renal nutrition supplement for oral use. It supports patients with chronic kidney disease and those requiring low‑protein diets.

GNH India supplies Ketosteril as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, dialysis units and pharmacies worldwide.

Manufacturer / TM Owner

Fresenius Kabi Deutschland Gmbh

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Indications & Clinical Uses

Ketosteril is used in renal nutrition to manage nitrogen balance in chronic kidney disease.

  • Chronic kidney disease (CKD): helps maintain essential amino acid levels while reducing nitrogenous waste.
  • Low‑protein diet in renal failure: provides keto‑analogues that are converted to essential amino acids, supporting nutrition.
  • Dialysis patients: assists in preserving nutritional status during renal replacement therapy.

How It Works

  • Ketosteril supplies keto‑analogues of essential amino acids that are taken up by cells and transaminated using nitrogen from non‑essential amino acids, forming the corresponding essential amino acids. This process supplies needed amino acids while limiting the generation of nitrogenous waste products, thereby reducing uremic load in patients with chronic kidney disease.

Side Effects

Ketosteril may be associated with several adverse reactions, which are categorized by frequency.

Common Side Effects

  • Nausea: mild gastrointestinal upset.
  • Diarrhea: loose stools.
  • Loss of appetite: reduced food intake.
  • Muscle cramps: transient skeletal muscle discomfort.

Serious or Rare Side Effects

  • Hyperkalemia: elevated serum potassium.
  • Metabolic acidosis: significant acid‑base disturbance.
  • Allergic reactions: rash, pruritus, or angioedema.

Precautions & Warnings

When using Ketosteril, consider the following precautions.

  • Dose adjustment: individualize based on renal function and dietary protein intake.
  • Monitor electrolytes: regularly check serum potassium and phosphorus.
  • Liver function: assess hepatic enzymes periodically.
  • Pregnancy and lactation: use only if clearly needed; safety not established.
  • Drug interactions: review concomitant medications that affect nitrogen balance.
  • Store at ambient temperature: keep below 25 °C, protect from moisture and light in original packaging.

Avoid Interactions

Ketosteril can interact with other medicines; interactions are grouped by severity.

Major Interactions (Avoid)

  • High‑protein supplements: may counteract the low‑nitrogen goal.
  • Sodium bicarbonate: can alter acid‑base balance when combined improperly.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: may affect potassium levels.
  • Diuretics: can influence electrolyte balance.
  • Phosphate binders: may interfere with absorption of keto‑analogues.

Frequently Asked Questions

Ketosteril is a renal nutrition supplement indicated for patients with chronic kidney disease, those on low‑protein diets, and individuals receiving dialysis. It helps maintain essential amino acid levels while reducing nitrogenous waste, supporting overall nutritional status in renal impairment.

The formulation contains keto‑analogues of essential amino acids. These compounds are transaminated in the body, using nitrogen from non‑essential amino acids to form the required essential amino acids. This process supplies needed proteins while limiting the production of nitrogenous waste.

The appropriate dose of Ketosteril is determined by the prescribing healthcare professional based on the patient’s renal function, dietary protein intake, and overall clinical condition. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety of Ketosteril in pregnancy and lactation has not been fully established. It should only be used if the potential benefit justifies any potential risk to the fetus or infant, and this decision must be made by a qualified healthcare provider.

To order Ketosteril, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Ketosteril provides keto‑analogues that are directly transaminated to essential amino acids, offering a nitrogen‑sparing effect. Compared with standard amino‑acid supplements, it may reduce uremic toxin buildup more effectively, making it a preferred option for patients requiring strict protein restriction.

Ketosteril should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct light, and ensure the container is tightly closed to maintain stability.

Ketosteril is taken orally, usually with water. It may be administered with meals or as directed by the prescriber to align with the patient’s dietary plan and renal treatment schedule.

Serious risks include hyperkalemia, metabolic acidosis, and severe allergic reactions such as rash, pruritus, or angioedema. Patients should be monitored regularly for electrolyte disturbances and any signs of hypersensitivity.

Ketosteril is contraindicated in patients with known hypersensitivity to any of its components. Caution is advised for individuals with uncontrolled hyperkalemia, severe liver disease, or those who cannot adhere to a low‑protein dietary regimen.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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