Product image of Ketozolin (Ketoconazole) supplied by GNH India

Ketozolin

Active Ingredient:
Ketoconazole
Origin:
EU

Ketozolin (Ketoconazole)

Ketoconazole, the active ingredient in Ketozolin, is an imidazole antifungal presented as a topical formulation for topical use. It treats superficial fungal infections such as athlete’s foot, ringworm and yeast infections in adults and children.

GNH India supplies Ketozolin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to EU quality standards and provides reliable distribution to healthcare providers across multiple regions.

Manufacturer / TM Owner

Dermapharm Ag

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Indications & Clinical Uses

  • Ketozolin, an imidazole antifungal, is used to treat a range of superficial fungal skin conditions.
  • Tinea corporis: reduces lesion size and alleviates itching and scaling.
  • Tinea cruris: clears the infection and relieves discomfort in the groin area.
  • Tinea pedis: eliminates athlete’s foot symptoms and prevents spread.
  • Candidiasis: eradicates cutaneous yeast overgrowth and soothes irritation.
  • Seborrheic dermatitis: controls flaking and redness associated with the condition.

How It Works

  • Ketoconazole inhibits the fungal enzyme lanosterol 14α‑demethylase, a key step in ergosterol synthesis. By blocking ergosterol production, the drug disrupts the integrity of the fungal cell membrane, leading to increased permeability and ultimately cell death. This targeted action limits fungal growth on the skin surface without affecting human cells.

Side Effects

Topical ketoconazole may cause local and systemic adverse reactions.

Common Side Effects

  • Skin irritation: mild redness, burning, or stinging at the application site.
  • Pruritus: transient itching after application.
  • Dryness: localized skin dryness or flaking.
  • Erythema: mild redness of treated skin.
  • Contact dermatitis: mild allergic skin reaction.

Serious or Rare Side Effects

  • Allergic contact dermatitis: severe rash, swelling, or blistering requiring medical attention.
  • Hepatotoxicity: rare systemic absorption leading to liver enzyme elevation.
  • Stevens‑Johnson syndrome: extremely rare severe skin reaction.
  • Photosensitivity: heightened skin sensitivity to sunlight.

Precautions & Warnings

  • Before using Ketozolin, consider the following safety measures.
  • Application area: limit to affected skin only and avoid mucous membranes.
  • Duration of therapy: do not exceed the prescribed treatment period without medical advice.
  • Compromised skin: use with caution on broken or inflamed skin.
  • Pregnancy and lactation: consult a healthcare professional before use.
  • Concurrent topical agents: avoid simultaneous use with other antifungal or corticosteroid creams unless directed.
  • Store at below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Ketozolin may interact with other medications or topical products.

Major Interactions (Avoid)

  • Systemic azole antifungals: concurrent use can increase systemic ketoconazole exposure and toxicity.
  • Topical corticosteroids: may reduce antifungal efficacy and delay healing.

Moderate Interactions (Monitor Closely)

  • Alcohol‑based skin products: may increase local irritation.
  • Other topical agents (e.g., retinoids, salicylic acid): monitor for enhanced skin sensitivity.
  • Phototoxic agents: advise patients to limit sun exposure while using the product.

Frequently Asked Questions

Ketozolin is a topical antifungal medication indicated for the treatment of superficial fungal infections such as tinea corporis (ringworm), tinea cruris (jock itch), tinea pedis (athlete’s foot), cutaneous candidiasis, and seborrheic dermatitis. It works by eliminating the fungi that cause these skin conditions, helping to relieve symptoms like itching, redness, and scaling.

Ketoconazole, the active ingredient in Ketozolin, blocks the fungal enzyme lanosterol 14α‑demethylase, which is essential for producing ergosterol, a key component of the fungal cell membrane. Without ergosterol, the membrane becomes unstable, leading to fungal cell death and a reduction in the infection on the skin.

The dosage of Ketozolin is determined by the prescribing healthcare professional based on the specific infection, its severity, and the patient’s age and condition. The prescriber will provide detailed instructions on how much product to apply, how often, and for how many days.

Safety data for topical ketoconazole during pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss the potential risks and benefits with their healthcare provider before using Ketozolin.

To order Ketozolin, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide. After the request, the sales team will verify trade or institutional credentials and respond with pricing, availability, shipping details, and any necessary import documentation.

Ketozolin (ketoconazole) belongs to the imidazole class of antifungals, offering broad‑spectrum activity against dermatophytes and yeasts. Compared with allylamine agents such as terbinafine, ketoconazole has a slightly different spectrum and may be preferred for infections where yeasts predominate, such as candidiasis. Choice of therapy depends on the pathogen, site of infection, and patient factors.

Ketozolin should be stored at temperatures below 25 °C (77 °F). Keep the product in its original container, protect it from moisture, excessive heat, and direct sunlight. Ensure the cap is tightly closed after each use to maintain product stability.

Ketozolin is applied topically to the affected skin area. Clean and dry the skin before use, then apply a thin layer of the product to the lesion and a small margin of surrounding skin. Wash hands after application unless the hands are the treatment site. Follow the prescriber’s frequency and duration instructions.

While rare, serious adverse reactions can include severe allergic contact dermatitis, systemic absorption leading to liver enzyme elevation, and, in extremely uncommon cases, Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they experience widespread rash, swelling, blistering, or signs of liver dysfunction such as jaundice.

Ketozolin should not be used by individuals with a known hypersensitivity to ketoconazole, other imidazole antifungals, or any component of the formulation. It is also contraindicated on large areas of broken skin or mucous membranes unless specifically directed by a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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