Ketrel (Tretinoin)

Tretinoin binds to nuclear retinoic acid receptors (RAR‑α, RAR‑β, RAR‑γ) in epidermal cells, altering gene expression that controls keratinocyte differentiation and proliferation. This leads to faster shedding of dead cells, reduced follicular blockage and stimulation of collagen production.

The exact dosing frequency and amount of Ketrel are set by the prescribing healthcare professional based on the patient’s skin type, severity of the condition and tolerance. Patients should follow the prescriber’s instructions and not adjust the regimen on their own.

Ketrel is classified as Pregnancy Category X, meaning it is contraindicated in pregnancy because systemic absorption may cause fetal harm. It is also not recommended during breastfeeding, as retinoids can be excreted in milk and affect the infant.

To request Ketrel, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Ketrel (tretinoin) works by modulating gene expression and normalizing skin cell turnover, whereas benzoyl peroxide primarily provides antibacterial action and rapid lesion drying. Tretinoin offers longer‑term improvement in skin texture and comedone prevention, but may cause more irritation; combination therapy is sometimes used under medical supervision.

Ketrel should be stored at room temperature, below 25 °C, in its original container. Protect the product from excess moisture and direct light to maintain stability and potency throughout its shelf life.

Apply a thin layer of Ketrel to clean, dry skin once daily, preferably in the evening, unless otherwise directed by a clinician. Avoid the eyes, lips, nostrils and any broken or inflamed skin. Wash hands after application.

Serious risks include severe dermatitis, marked photosensitivity and allergic contact dermatitis. If any of these reactions develop, discontinue use immediately and seek medical attention, as they may require specific treatment or alternative therapy.

Ketrel should not be used by individuals who are pregnant, planning pregnancy, or breastfeeding. It is also contraindicated in patients with known hypersensitivity to tretinoin or any component of the formulation, and in those with extensive skin damage or active dermatitis in the treatment area.