Ketrel (Tretinoin)

Tretinoin binds to nuclear retinoic acid receptors in epidermal cells, altering gene expression that promotes differentiation and reduces proliferation of keratinocytes. This action decreases follicular plugging, limits inflammation, and encourages smoother, more evenly pigmented skin.

The specific dosage and frequency of Ketrel are determined by the prescribing clinician based on the patient’s condition, skin type and tolerance. Physicians typically start with a low concentration applied once daily to the affected area and adjust as needed.

Safety of topical tretinoin in pregnancy and lactation has not been established. Health professionals generally advise avoiding its use in pregnant or breastfeeding individuals because of potential teratogenic risk and unknown transfer into breast milk.

To request Ketrel, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Ketrel (tretinoin) is a retinoid that directly modifies skin cell turnover, whereas many antibiotics target bacterial growth and benzoyl peroxide provides oxidative killing. Retinoids often produce longer‑term improvement in comedones and texture, but may cause more irritation compared with some non‑retinoid options.

Ketrel should be stored at room temperature, below 25 °C, in its original packaging. Keep the container tightly closed, protect it from moisture and direct sunlight to maintain product stability.

Ketrel is applied topically to clean, dry skin. A thin layer is spread over the affected area, usually once daily in the evening, unless the prescriber advises a different regimen. Hands should be washed after application and contact with eyes avoided.

Serious risks include severe allergic reactions, blistering dermatitis, Stevens‑Johnson syndrome, and marked photosensitivity. Patients should seek immediate medical attention if they develop extensive rash, swelling, blistering, or systemic symptoms such as fever.

Ketrel is contraindicated in individuals with known hypersensitivity to tretinoin or any formulation component, in patients with severe eczema or dermatitis on the treatment area, and generally should be avoided by pregnant or nursing persons unless directed by a qualified clinician.