Product image of Kevesy (Levetiracetam) supplied by GNH India

Kevesy

Active Ingredient:
Levetiracetam
Origin:
EU

Kevesy (Levetiracetam)

Levetiracetam, the active ingredient in Kevesy, is a pyrrolidine derivative presented as an intravenous solution for intravenous use. It treats partial‑onset, generalized tonic‑clonic and myoclonic seizures in patients requiring acute seizure control.

GNH India supplies Kevesy as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Stragen Nordic A/S

1
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Indications & Clinical Uses

  • Levetiracetam is an antiepileptic drug used to manage several seizure types.
  • Partial‑onset seizures: reduces seizure frequency and severity in focal epilepsy.
  • Generalized tonic‑clonic seizures: provides rapid control of convulsive episodes.
  • Myoclonic seizures: helps prevent sudden muscle jerks associated with juvenile myoclonic epilepsy.

How It Works

  • Levetiracetam binds to the synaptic vesicle protein SV2A, modulating neurotransmitter release and stabilizing neuronal firing. This interaction reduces abnormal electrical activity in the brain, contributing to seizure control, although the precise downstream pathways remain incompletely defined.

Side Effects

Levetiracetam may cause a range of adverse reactions, most of which are mild to moderate.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Fatigue: generalized tiredness.
  • Dizziness: sensation of light‑headedness.
  • Somnolence: increased sleepiness.
  • Nausea: occasional upset stomach.
  • Irritability: mood changes or agitation.

Serious or Rare Side Effects

  • Severe allergic reactions: rash, swelling, or anaphylaxis.
  • Stevens‑Johnson syndrome: rare skin disorder.
  • Blood dyscrasias: neutropenia or thrombocytopenia.
  • Suicidal ideation: thoughts of self‑harm.
  • Respiratory depression: especially with concomitant depressants.
  • Hepatic injury: elevated liver enzymes.

Precautions & Warnings

  • When using Kevesy, clinicians should consider several safety aspects.
  • Renal impairment: adjust dosing according to renal function.
  • Hepatic impairment: monitor liver enzymes regularly.
  • Pregnancy: use only if potential benefit justifies the risk.
  • Concomitant CNS depressants: observe for additive sedation.
  • Psychiatric symptoms: watch for mood changes or aggression.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Levetiracetam can interact with other medicines, requiring attention to avoid reduced efficacy or increased toxicity.

Major Interactions (Avoid)

  • Incompatible IV solutions: do not mix with calcium‑containing infusions.
  • Live vaccines: may diminish vaccine efficacy.

Moderate Interactions (Monitor Closely)

  • Enzyme‑inducing antiepileptics (e.g., carbamazepine, phenytoin): may lower levetiracetam levels.
  • CNS depressants (e.g., benzodiazepines, alcohol): increase sedation risk.
  • Antidepressants (e.g., SSRIs): monitor for mood alterations.
  • Renal‑clearing drugs (e.g., aminoglycosides): assess renal function.

Frequently Asked Questions

Kevesy is an intravenous formulation of levetiracetam indicated for the treatment of partial‑onset, generalized tonic‑clonic and myoclonic seizures in patients who need rapid seizure control, typically in hospital or emergency settings.

Levetiracetam binds to the synaptic vesicle protein SV2A, which modulates neurotransmitter release and stabilizes neuronal excitability. This action reduces the likelihood of abnormal electrical discharges that cause seizures, though the exact downstream mechanisms are not fully understood.

The specific dose of Kevesy is determined by the prescribing clinician based on the patient’s age, weight, renal function, and clinical situation. Healthcare professionals set the appropriate infusion rate and total daily amount according to established guidelines.

The safety of levetiracetam in pregnancy and lactation has not been definitively established. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and decisions should be made in consultation with a healthcare provider.

To order Kevesy, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and necessary import documentation.

Kevesy (levetiracetam) offers a favorable safety profile, minimal protein binding, and limited drug‑drug interactions compared with many traditional IV antiepileptics such as phenytoin or phenobarbital. Its rapid onset and ease of dosing make it a preferred option for acute seizure management in many clinical settings.

Kevesy should be stored at 2‑8 °C, protected from light, and kept in its original packaging. Do not freeze or shake the solution. Before administration, inspect for particulate matter or discoloration and use aseptic technique.

Kevesy is given by intravenous infusion. The rate and duration are determined by the prescriber, typically over 15 minutes to an hour, depending on the clinical scenario and patient tolerance.

Serious risks include severe allergic reactions, Stevens‑Johnson syndrome, blood dyscrasias, suicidal thoughts, and respiratory depression, especially when combined with other central nervous system depressants. Prompt recognition and medical intervention are essential if these events occur.

Kevesy is contraindicated in patients with known hypersensitivity to levetiracetam or any component of the formulation. Caution is advised for individuals with severe renal impairment, uncontrolled psychiatric disorders, or those receiving incompatible IV solutions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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