Product image of Kevindol (Ketorolac Trometamol) supplied by GNH India

Kevindol

Active Ingredient:
Ketorolac Trometamol
Origin:
EU

Kevindol (Ketorolac Trometamol)

Ketorolac Trometamol, the active ingredient in Kevindol, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an injection solution for intramuscular and intravenous use. It provides short‑term management of moderate to severe pain in postoperative or trauma patients.

GNH India supplies Kevindol as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

So.Se.Pharm S.R.L.

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Indications & Clinical Uses

Ketorolac Trometamol is a non‑selective NSAID used for acute pain management.

  • Post‑operative pain: provides rapid analgesia after surgical procedures.
  • Acute musculoskeletal pain: reduces pain from injuries or strains.
  • Renal colic: alleviates severe pain associated with kidney stones.

How It Works

  • Ketorolac Trometamol inhibits cyclooxygenase enzymes COX‑1 and COX‑2, decreasing the conversion of arachidonic acid to prostaglandins. This reduction in prostaglandin synthesis diminishes inflammation, lowers peripheral sensitisation of nociceptors, and produces potent analgesic and antipyretic effects without directly acting on opioid receptors.

Side Effects

Ketorolac Trometamol may cause a range of adverse reactions.

Common Side Effects

  • Injection site pain: discomfort at the site of administration.
  • Nausea: feeling of sickness or urge to vomit.
  • Dyspepsia: indigestion or stomach upset.
  • Headache: mild to moderate head pain.

Serious or Rare Side Effects

  • Gastrointestinal bleeding: potentially life‑threatening hemorrhage.
  • Renal impairment: reduced kidney function, especially with prolonged use.
  • Severe allergic reaction (anaphylaxis): rapid onset of swelling, rash, and breathing difficulty.

Precautions & Warnings

When using Kevindol, clinicians should observe several safety measures.

  • Assess renal function: avoid or adjust dose in severe renal impairment.
  • Monitor gastrointestinal risk: use the lowest effective dose to limit ulcer or bleeding risk.
  • Evaluate bleeding risk: contraindicated in patients with active peptic ulcer or uncontrolled hemorrhage.
  • Use caution in the elderly: increased susceptibility to adverse effects.
  • Store at ambient temperature: keep in the original container, protect from light and moisture.

Avoid Interactions

Ketorolac Trometamol can interact with several drug classes.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): heightened risk of bleeding.
  • Other NSAIDs: additive gastrointestinal toxicity.
  • ACE inhibitors or ARBs: may worsen renal function.
  • Lithium: increased serum lithium concentrations.

Moderate Interactions (Monitor Closely)

  • Diuretics: potential impact on renal clearance.
  • Methotrexate: may increase methotrexate toxicity.
  • SSRIs: possible enhancement of bleeding tendency.

Frequently Asked Questions

Kevindol is an injectable formulation of ketorolac trometamol indicated for the short‑term management of moderate to severe pain, such as post‑operative pain, acute musculoskeletal injuries, and renal colic. It is typically used when rapid analgesia is required and when non‑opioid therapy is preferred.

Ketorolac trometamol works by non‑selectively inhibiting the cyclooxygenase enzymes COX‑1 and COX‑2. This inhibition blocks the synthesis of prostaglandins, which are mediators of inflammation, pain, and fever, thereby providing potent analgesic and anti‑inflammatory effects.

The specific dose of Kevindol is determined by the prescribing clinician based on the patient’s condition, weight, renal function, and route of administration. Healthcare professionals follow local guidelines and adjust the regimen to achieve effective pain control while minimising risk.

Safety of ketorolac trometamol during pregnancy and lactation has not been established. Because NSAIDs may affect fetal circulation and reduce milk production, Kevindol is generally avoided unless the potential benefit justifies the potential risk to the fetus or infant.

To order Kevindol, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and required import documentation.

Compared with many oral NSAIDs, Kevindol offers rapid onset of action due to its injectable form, making it useful for acute severe pain where oral administration is impractical. Unlike opioid analgesics, it does not cause respiratory depression, but it shares the gastrointestinal and renal risks typical of NSAIDs.

Kevindol should be stored at ambient temperature, below 25 °C, in its original packaging. Protect the vials from direct sunlight, moisture, and extreme temperature fluctuations. Do not freeze the product, and inspect for particulate matter before administration.

Kevindol is supplied as a sterile injection solution for intramuscular or intravenous use. Administration is performed by a qualified healthcare professional, who selects the appropriate route, dose, and infusion rate according to the patient’s clinical needs and monitoring requirements.

The most serious risks include gastrointestinal bleeding or perforation, severe renal impairment, and life‑threatening allergic reactions such as anaphylaxis. Patients with a history of ulcers, bleeding disorders, or compromised kidney function require careful assessment before receiving Kevindol.

Kevindol should be avoided in patients with active peptic ulcer disease, uncontrolled bleeding, severe renal or hepatic impairment, known hypersensitivity to ketorolac or other NSAIDs, and in those who have had a recent coronary artery bypass graft. Caution is also advised for the elderly and for patients on anticoagulants.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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