Product image of Kevzara (Sarilumab) supplied by GNH India

Kevzara

Active Ingredient:
Sarilumab
Origin:
EU

Kevzara (Sarilumab)

Sarilumab, the active ingredient in Kevzara, is a IL-6 receptor antagonist presented as a 200 mg/1.5 mL prefilled syringe for subcutaneous use. It treats rheumatoid arthritis in adult patients who require disease‑modifying therapy.
GNH India supplies Kevzara as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Sanofi Winthrop Industrie

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Indications & Clinical Uses

Kevzara acts on the interleukin‑6 pathway to modify disease activity in rheumatoid arthritis.

  • Rheumatoid arthritis (moderate to severe): reduces joint pain, swelling and stiffness.
  • Rheumatoid arthritis with inadequate response to prior DMARDs: provides additional disease control.
  • Adult rheumatoid arthritis: improves physical function and slows radiographic progression.

How It Works

  • Sarilumab is a fully human monoclonal antibody that binds with high affinity to both soluble and membrane‑bound IL‑6 receptors. By blocking IL‑6 from interacting with its receptor, the drug inhibits downstream JAK/STAT signaling, reducing inflammatory cytokine production and immune cell activation associated with rheumatoid arthritis.

Side Effects

Common Side Effects

  • Injection site reactions: pain, erythema, or swelling at the injection site.
  • Neutropenia: reduced neutrophil count observed in laboratory tests.
  • Elevated liver enzymes: increases in ALT or AST levels.
  • Upper respiratory tract infection: symptoms such as sore throat or nasal congestion.
  • Headache: mild to moderate intensity.
  • Hypertension: elevated blood pressure readings.

Serious or Rare Side Effects

  • Serious infections: including bacterial, viral, or fungal infections requiring medical attention.
  • Gastrointestinal perforation: rare but potentially life‑threatening.
  • Hypersensitivity reactions: including anaphylaxis or severe skin reactions.
  • Cytopenias: significant reductions in blood cell lines beyond neutropenia.
  • Liver failure: severe hepatic injury with jaundice or coagulopathy.
  • Anaphylaxis: acute, systemic allergic response requiring emergency care.

Precautions & Warnings

Before initiating therapy, clinicians should evaluate patient risk factors and monitor laboratory parameters.

  • Screen for active infections: assess and treat before starting Kevzara.
  • Monitor complete blood count: watch for neutropenia and other cytopenias.
  • Assess liver function: check transaminases regularly during treatment.
  • Evaluate lipid profile: IL‑6 blockade may alter cholesterol levels.
  • Vaccination: administer required vaccines prior to therapy.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Sarilumab may interact with other agents that affect immune function or drug metabolism.

Major Interactions (Avoid)

  • Live vaccines: contraindicated during treatment.
  • Strong immunosuppressants (e.g., high‑dose corticosteroids): may increase infection risk.
  • Cytochrome P450 substrates: IL‑6 blockade can alter metabolism; monitor levels.

Moderate Interactions (Monitor Closely)

  • Non‑live vaccines: may have reduced efficacy; assess response.
  • Anticoagulants: monitor INR as inflammatory changes can affect coagulation.
  • Concomitant DMARDs: adjust dosing based on clinical response and safety.

Frequently Asked Questions

Kevzara is prescribed for the treatment of moderate to severe rheumatoid arthritis in adult patients, particularly when the disease has not responded adequately to conventional disease‑modifying antirheumatic drugs.

Sarilumab is a monoclonal antibody that binds to both soluble and membrane‑bound interleukin‑6 receptors, preventing IL‑6 from activating its signaling pathway. This inhibition reduces inflammatory responses and immune system activation that drive joint damage in rheumatoid arthritis.

The prescribed dose of Kevzara is determined by the treating physician based on the patient’s clinical condition, weight, and response to therapy. The medication is supplied as a 200 mg prefilled syringe for subcutaneous injection.

The safety of Kevzara in pregnancy and lactation has not been established. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and decisions should be made in consultation with a healthcare professional.

To order Kevzara, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, cold‑chain shipping details and necessary import documentation.

Kevzara (sarilumab) and other IL‑6 inhibitors such as tocilizumab share a similar mechanism of blocking IL‑6 signaling. Differences may include dosing frequency, formulation (subcutaneous vs. intravenous), and specific safety profiles, which are evaluated by clinicians to match patient needs.

Kevzara must be stored refrigerated at 2‑8 °C, protected from light, and should never be frozen or shaken. The prefilled syringe should be kept in its original packaging until ready for administration.

Kevzara is given as a subcutaneous injection using the prefilled 200 mg syringe. The injection is typically performed by a healthcare professional in a clinical setting, following aseptic technique and the manufacturer’s administration guidelines.

Serious risks include severe infections, gastrointestinal perforation, hypersensitivity reactions such as anaphylaxis, and significant laboratory abnormalities like neutropenia or elevated liver enzymes. Patients should be monitored closely for signs of infection or organ dysfunction.

Kevzara is contraindicated in patients with known hypersensitivity to sarilumab or any component of the formulation, and it should be avoided in individuals receiving live vaccines. Caution is also advised for patients with active, uncontrolled infections.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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