Kidiaven (Valine, Acetylcysteine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine)

Kidiaven is used in the context of parenteral nutrition to provide essential amino acids for patients who cannot obtain nutrition enterally.

• Total parenteral nutrition support: provides a complete amino acid profile to maintain nitrogen balance in patients unable to meet nutritional needs via the gastrointestinal tract.
• Pediatric parenteral nutrition: supplies age‑appropriate amino acids for children requiring intravenous nutrition.
• Pre‑ and post‑operative nutritional support: helps preserve lean body mass and promotes wound healing around surgical procedures.
• Critical care nutrition: contributes to metabolic stability in intensive care patients receiving prolonged intravenous feeding.

• Kidiaven delivers a balanced mixture of essential and non‑essential amino acids directly into the bloodstream, bypassing the gastrointestinal tract. The supplied amino acids become substrates for protein synthesis, restore nitrogen balance, and support tissue repair and metabolic functions in patients receiving parenteral nutrition, thereby maintaining lean body mass and facilitating recovery.

Adverse reactions may occur with any parenteral amino acid solution and should be monitored.

Common Side Effects

• Hyperglycaemia: elevated blood glucose levels during infusion.
• Electrolyte disturbances: shifts in potassium, sodium or calcium concentrations.
• Local infusion site reactions: erythema, pain or swelling at the injection site.

Serious or Rare Side Effects

• Anaphylactic reaction: severe hypersensitivity requiring immediate medical intervention.
• Metabolic acidosis: significant drop in blood pH due to amino acid metabolism.
• Hepatic dysfunction: abnormal liver enzyme elevations in susceptible patients.

Kidiaven requires careful clinical monitoring to ensure safe use.

• Assess renal function: adjust infusion rates in patients with impaired kidney function.
• Monitor blood glucose: check glucose levels regularly, especially in diabetic patients.
• Observe electrolyte status: correct imbalances before and during therapy.
• Evaluate hepatic function: watch for signs of liver stress in long‑term use.
• Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Amino acid solutions can interact with other intravenous therapies and metabolic conditions.

Major Interactions (Avoid)

• High‑dose potassium supplements: may cause severe hyperkalaemia when combined with amino acid infusion.
• Certain antibiotics (e.g., aminoglycosides): increased risk of nephrotoxicity when administered concurrently.

Moderate Interactions (Monitor Closely)

• Insulin therapy: may require dose adjustment due to glucose‑raising effect of amino acids.
• Diuretics: monitor electrolytes closely as diuretics can exacerbate electrolyte shifts.
• Other parenteral nutrition components: coordinate infusion schedules to avoid incompatibility and precipitation.