Product image of Kinderparacetamol Zetpil Htp (Paracetamol) supplied by GNH India

Kinderparacetamol Zetpil Htp

Active Ingredient:
Paracetamol
Origin:
EU

Kinderparacetamol Zetpil Htp (Paracetamol)

Paracetamol, the active ingredient in Kinderparacetamol Zetpil Htp, is an analgesic presented as a rectal suppository. It is used to relieve mild to moderate pain and to lower fever, particularly in pediatric patients who may have difficulty with oral administration. The formulation is designed for rapid absorption through the rectal mucosa and ensures consistent therapeutic levels.

GNH India supplies Kinderparacetamol Zetpil Htp as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with a focus on quality and regulatory compliance.

Manufacturer / TM Owner

Healthypharm B.V.

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Indications & Clinical Uses

Paracetamol is an analgesic and antipyretic that acts on the pain and fever pathways in the body.

  • Pain: Provides relief of mild to moderate pain in children.
  • Fever: Reduces elevated body temperature associated with infection or inflammation.
  • Headache: Alleviates tension‑type headaches in pediatric patients.
  • Dental pain: Eases discomfort after dental procedures.
  • Post‑vaccination fever: Controls fever following immunisation.

How It Works

  • Paracetamol exerts its effect by inhibiting cyclooxygenase enzymes (COX‑1 and COX‑2) in the central nervous system, which reduces the synthesis of prostaglandins involved in pain signaling and thermoregulation. This central action lowers the perception of pain and resets the hypothalamic set‑point for body temperature, providing antipyretic and analgesic effects without significant peripheral anti‑inflammatory activity.

Side Effects

Paracetamol is generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Rectal irritation: Local discomfort at the site of administration.
  • Nausea: Mild upset stomach.
  • Abdominal discomfort: General stomach unease.
  • Dizziness: Transient light‑headedness.
  • Rash: Minor skin irritation.
  • Diarrhoea: Loose stools.

Serious or Rare Side Effects

  • Severe allergic reaction (anaphylaxis): Difficulty breathing, swelling.
  • Stevens‑Johnson syndrome: Severe skin blistering.
  • Liver toxicity: Elevated liver enzymes, jaundice.
  • Blood disorders: Neutropenia or thrombocytopenia.
  • Hypersensitivity reactions: Fever, chills, or unexplained malaise.
  • Renal impairment: Reduced kidney function in susceptible individuals.

Precautions & Warnings

Paracetamol should be used with attention to patient safety and proper handling.

  • Liver function assessment: Evaluate hepatic status before use, especially in prolonged therapy.
  • Dose limitation: Do not exceed the recommended total daily dose of paracetamol from all sources.
  • Hypersensitivity: Avoid in patients with known allergy to paracetamol or related compounds.
  • Concomitant use: Do not combine with other paracetamol‑containing products.
  • Storage: Store at room temperature: keep in the original pack, protect from moisture and heat.

Avoid Interactions

Paracetamol may interact with other medicines, requiring careful management.

Major Interactions (Avoid)

  • Other paracetamol‑containing products: Increases risk of overdose and liver toxicity.
  • Warfarin: May enhance anticoagulant effect and increase bleeding risk.
  • High‑dose alcohol: Potentiates hepatotoxicity.
  • Isoniazid: Elevates risk of liver injury.

Moderate Interactions (Monitor Closely)

  • Rifampicin: May reduce paracetamol plasma concentrations.
  • Phenobarbital: May increase metabolism, lowering efficacy.
  • Carbamazepine: May decrease therapeutic levels.
  • Acetylcysteine (antidote): Monitor for potential interactions during overdose treatment.

Frequently Asked Questions

Kinderparacetamol Zetpil Htp is a rectal suppository containing paracetamol, used to relieve mild to moderate pain and to reduce fever in children who may have difficulty taking oral medication.

Paracetamol works by inhibiting central cyclooxygenase enzymes, which lowers prostaglandin production in the brain. This reduces the perception of pain and resets the hypothalamic temperature set‑point, providing analgesic and antipyretic effects.

The appropriate dose is determined by the prescribing healthcare professional based on the child’s age, weight, and clinical condition. The prescriber will specify the exact amount and frequency of administration.

Safety data for rectal paracetamol in pregnancy and lactation are limited. Healthcare providers should evaluate the risk‑benefit ratio before prescribing to pregnant or breastfeeding mothers.

To place an order, submit an enquiry on the product page at gnhindia.com, indicating the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Compared with ibuprofen, paracetamol has minimal anti‑inflammatory activity but a lower risk of gastrointestinal irritation. It is often preferred for children who cannot tolerate NSAIDs or have contraindications to them.

Store the suppositories at room temperature, ideally below 25 °C, in the original packaging. Protect them from moisture, direct sunlight, and excessive heat to maintain product stability.

The suppository is inserted rectally, following standard hygiene practices. The caregiver should ensure the child is in a comfortable position, gently insert the suppository past the anal sphincter, and allow it to dissolve completely.

Serious risks include severe allergic reactions such as anaphylaxis, rare skin conditions like Stevens‑Johnson syndrome, and liver toxicity, especially when the total daily dose of paracetamol from all sources exceeds recommended limits.

Children with known hypersensitivity to paracetamol, those who have received another paracetamol‑containing medication within the past 24 hours, or patients with severe liver disease should avoid using this product.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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