Product image of Kiovig (Human Normal Immunoglobulin) supplied by GNH India

Kiovig

Active Ingredient:
Human Normal Immunoglobulin
Origin:
EU

Kiovig (Human Normal Immunoglobulin)

Human normal immunoglobulin, the active ingredient in Kiovig, is an immunoglobulin presented as a solution for intravenous use. It provides passive immunity by supplying pooled IgG antibodies and is used in patients with primary immunodeficiency, immune thrombocytopenic purpura, Kawasaki disease and other immune‑mediated conditions.

GNH India supplies Kiovig as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Takeda Manufacturing Austria Ag

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Indications & Clinical Uses

Kiovig is an intravenous immunoglobulin used to treat disorders involving immune deficiency or dysregulation.

  • Primary immunodeficiency diseases: replaces missing antibodies to reduce infection risk.
  • Immune thrombocytopenic purpura (ITP): raises platelet counts and reduces bleeding.
  • Kawasaki disease: lowers incidence of coronary artery aneurysms.
  • Chronic inflammatory demyelinating polyneuropathy (CIDP): improves muscle strength and functional ability.

How It Works

  • Human normal immunoglobulin supplies a broad spectrum of pooled IgG antibodies that bind pathogens and neutralize toxins, providing passive immunity. It also modulates immune system activity by interacting with Fc receptors, complement pathways, and cytokine networks, thereby reducing auto‑antibody production and inflammatory responses.

Side Effects

Kiovig may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Fever or chills: typically during or shortly after infusion.
  • Nausea or vomiting: occasional gastrointestinal upset.
  • Fatigue: transient tiredness post‑infusion.
  • Muscle aches: mild myalgia.
  • Injection site reactions: redness or swelling.

Serious or Rare Side Effects

  • Anaphylaxis: severe allergic reaction requiring immediate medical attention.
  • Thromboembolic events: blood clots in veins or arteries.
  • Renal impairment: acute kidney injury, especially with high‑dose regimens.
  • Hemolysis: breakdown of red blood cells.
  • Aseptic meningitis: inflammation of the meninges without infection.
  • Transfusion‑related acute lung injury (TRALI): acute respiratory distress.

Precautions & Warnings

Before using Kiovig, consider the following safety measures.

  • Assess renal function: monitor creatinine and urine output.
  • Screen for IgA deficiency: risk of severe allergic reactions.
  • Evaluate thrombotic risk: avoid in patients with active clotting disorders.
  • Monitor for hemolysis: check hemoglobin and bilirubin levels.
  • Observe for signs of infection: ensure no active bacterial infection.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Kiovig can interact with other medications, requiring careful management.

Major Interactions (Avoid)

  • Live vaccines: may reduce vaccine efficacy or increase risk of infection.
  • High‑dose aspirin or anticoagulants: increased bleeding risk.

Moderate Interactions (Monitor Closely)

  • Immunosuppressants (e.g., cyclophosphamide): may alter immune response.
  • Diuretics: potential for renal stress.
  • ACE inhibitors: monitor blood pressure and renal function.
  • Corticosteroids: may affect infection risk.
  • Other IVIG products: avoid concurrent administration to prevent overload.

Frequently Asked Questions

Kiovig is an intravenous immunoglobulin indicated for primary immunodeficiency diseases, immune thrombocytopenic purpura (ITP), Kawasaki disease, and certain autoimmune neuropathies such as chronic inflammatory demyelinating polyneuropathy. It works by providing pooled IgG antibodies that replace deficient immune components and modulate abnormal immune activity.

Human normal immunoglobulin supplies a broad range of IgG antibodies that can bind to pathogens, neutralize toxins, and opsonize microbes for clearance. It also interacts with immune cells via Fc receptors, modulating cytokine production and reducing auto‑antibody formation, thereby restoring immune balance and providing passive protection.

The dose of Kiovig is individualized by the prescribing clinician based on the patient’s weight, indication, and clinical response. Healthcare providers calculate the appropriate infusion volume and rate according to established guidelines and monitor the patient throughout the administration.

The safety of Kiovig in pregnancy and lactation has not been definitively established. It should be used only if the potential benefit justifies any potential risk to the fetus or infant, and the decision must be made by the treating physician in consultation with the patient.

To order Kiovig, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details—including cold‑chain logistics—and necessary import documentation.

Kiovig is a high‑purity, solvent‑detergent‑treated IVIG product comparable to other branded IVIGs in terms of IgG content and safety profile. Differences may exist in stabilizers, infusion rates, and manufacturing processes, but clinical efficacy for approved indications is generally similar across products.

Kiovig must be stored refrigerated at 2‑8 °C. Keep the vials in their original packaging, protect them from light, and avoid freezing or shaking the product. Do not use if the solution appears discolored or contains particles.

Kiovig is given by intravenous infusion under the supervision of a qualified healthcare professional. The infusion rate is started slowly and may be increased as tolerated, with vital signs monitored throughout the procedure to detect any adverse reactions.

Serious risks include anaphylactic reactions, thromboembolic events, acute renal failure, hemolysis, aseptic meningitis, and transfusion‑related acute lung injury (TRALI). Patients should be closely monitored during and after infusion for any signs of these complications.

Kiovig is contraindicated in patients with a known severe IgA deficiency who have experienced anaphylaxis to blood products, and in those with a history of severe allergic reactions to immunoglobulin therapy. It should also be avoided in patients with uncontrolled hyperviscosity or active thrombotic disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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