Product image of Kisqali (Ribociclib ) 200mg Tablet supplied by GNH India

Kisqali

Active Ingredient:
Ribociclib
Form:
Tablet
Brand:
KISQALI
Origin:
Switzerland

Kisqali (Ribociclib Tablet) 200mg

Ribociclib, the active ingredient in Kisqali, is a cyclin-dependent kinase 4/6 (CDK4/6) inhibitor presented as a 200mg tablet for oral use. It is used in the treatment of hormone receptor-positive (HR+), HER2-negative advanced or metastatic breast cancer in combination with other therapies.

GNH India supplies Kisqali as a licensed, GDP-compliant international pharmaceutical supplier serving oncology centres worldwide.

Strength

200mg

Pack Size

42s

Storage

Ambient

Manufacturer / TM Owner

NOVARTIS PHARMA SCHWEIZ

1
Pack/s
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Indications & Clinical Uses

Kisqali is indicated for the treatment of breast cancer, specifically targeting the CDK4/6 pathway.

  • Hormone receptor-positive (HR+), HER2-negative advanced or metastatic breast cancer: Used in combination with an aromatase inhibitor or fulvestrant as initial endocrine-based therapy.
  • Adjuvant treatment for HR+, HER2-negative early breast cancer with a high risk of recurrence: Used in combination with an aromatase inhibitor.
  • Pre- or perimenopausal women with HR+, HER2-negative advanced breast cancer: Used in combination with an aromatase inhibitor and a luteinizing hormone-releasing hormone (LHRH) agonist.

How It Works

  • Kisqali works by selectively inhibiting cyclin-dependent kinases 4 and 6 (CDK4/6), which are involved in the regulation of the cell cycle. This inhibition leads to cell-cycle arrest in the G1 phase and prevents the proliferation of tumor cells, thereby slowing the progression of cancer.

Side Effects

Kisqali may cause various side effects, which can be categorized as common or serious.

Common Side Effects

  • Nausea
  • Fatigue
  • Diarrhea
  • Vomiting
  • Decreased appetite
  • Constipation
  • Hair loss
  • Rash

Serious or Rare Side Effects

  • Neutropenia (low white blood cell count)
  • Liver toxicity
  • QTc prolongation (heart rhythm abnormality)
  • Interstitial lung disease
  • Severe infections

Precautions & Warnings

Kisqali should be used with caution and certain precautions should be observed.

  • Monitoring: Regular monitoring of blood cell counts and liver function is recommended.
  • QTc Prolongation: Baseline and periodic ECG monitoring is advised.
  • Pregnancy: Kisqali should be avoided during pregnancy due to potential risks to the fetus.
  • Breastfeeding: It is not recommended to breastfeed while taking Kisqali.
  • Drug Interactions: Avoid concomitant use with strong CYP3A4 inducers or inhibitors.
  • Store below 25°C: Keep in the original pack, protect from moisture.

Avoid Interactions

Kisqali may interact with other medications, which can be categorized as major or moderate.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers (e.g., rifampin, phenytoin): May decrease the effectiveness of Kisqali.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): May increase the risk of side effects.
  • Drugs that prolong the QT interval (e.g., amiodarone, quinidine): May increase the risk of heart rhythm abnormalities.

Moderate Interactions (Monitor Closely)

  • Moderate CYP3A4 inducers (e.g., efavirenz, modafinil): May decrease the effectiveness of Kisqali.
  • Moderate CYP3A4 inhibitors (e.g., fluconazole, erythromycin): May increase the risk of side effects.
  • Drugs that are substrates of BCRP or OATP1B1 (e.g., rosuvastatin, methotrexate): May increase the risk of side effects.

Frequently Asked Questions

Kisqali is used in the treatment of hormone receptor-positive (HR+), HER2-negative advanced or metastatic breast cancer. It is typically used in combination with other therapies such as aromatase inhibitors or fulvestrant.

Ribociclib works by selectively inhibiting cyclin-dependent kinases 4 and 6 (CDK4/6), which are involved in the regulation of the cell cycle. This inhibition leads to cell-cycle arrest in the G1 phase and prevents the proliferation of tumor cells, thereby slowing the progression of cancer.

The usual dose of Kisqali is determined by a healthcare provider based on the patient's condition and response to treatment. It is typically taken as 600 mg (three 200 mg tablets) once daily for 21 days, followed by 7 days off, forming a 28-day treatment cycle.

Kisqali should be avoided during pregnancy due to potential risks to the fetus. It is also not recommended to breastfeed while taking Kisqali. Always consult with a healthcare provider for personalized advice.

To order Kisqali from GNH India, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams across international markets and will ask the buyer to confirm trade or institutional credentials. The team will then reply with pricing, availability, shipping, and the import paperwork.

Kisqali is a CDK4/6 inhibitor, which is a relatively newer class of drugs compared to traditional chemotherapy or hormone therapy. It is specifically indicated for HR+, HER2-negative breast cancer and is used in combination with other therapies. The choice of treatment depends on the specific characteristics of the cancer and the patient's overall health.

Kisqali should be stored at room temperature in its original package, protected from light and moisture. It should be kept out of the reach of children. Always follow the storage instructions provided by the manufacturer.

Kisqali is taken orally as a tablet. The tablets should be swallowed whole with a glass of water and should not be crushed or broken. It is important to take the medication at approximately the same time each day, whether with food or on an empty stomach.

The most serious risks associated with Kisqali include neutropenia (low white blood cell count), liver toxicity, QTc prolongation (heart rhythm abnormality), and interstitial lung disease. Regular monitoring and prompt reporting of any unusual symptoms to a healthcare provider are essential.

Kisqali should not be used by individuals who are allergic to ribociclib or any of its ingredients. It should also be avoided during pregnancy and breastfeeding. Patients with certain medical conditions or those taking specific medications that interact with Kisqali should consult their healthcare provider before starting treatment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

References

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