Product image of Kitonail (Ciclopirox) supplied by GNH India

Kitonail

Active Ingredient:
Ciclopirox
Origin:
EU

Kitonail (Ciclopirox)

Ciclopirox, the active ingredient in Kitonail, is an antifungal presented as a nail lacquer (strength not specified) for topical use. It treats fungal nail infections such as onychomycosis in adults. GNH India supplies Kitonail as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Polichem S.A.

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Indications & Clinical Uses

  • Ciclopirox is used to treat fungal infections of the nail and skin.
  • Onychomycosis: reduces fungal growth and promotes clearance of infected nails.
  • Dermatophytosis: eliminates skin‑surface fungi causing conditions such as athlete's foot and ringworm.

How It Works

  • Ciclopirox inhibits fungal sterol synthesis by chelating polyvalent cations, which disrupts membrane transport and essential cellular functions. This interference impairs fungal cell growth and replication, leading to eradication of the pathogen at the site of application.

Side Effects

Ciclopirox may cause local and systemic adverse reactions.

Common Side Effects

  • Application site irritation: mild redness or discomfort where applied.
  • Pruritus: itching of the treated area.
  • Dryness or peeling of the nail surface.
  • Burning sensation during or after application.
  • Discoloration of the nail plate.
  • Erythema: localized skin redness.

Serious or Rare Side Effects

  • Allergic contact dermatitis: severe skin reaction with swelling and blisters.
  • Systemic hypersensitivity: rare systemic allergic response such as urticaria.
  • Severe skin reaction: Stevens‑Johnson syndrome or toxic epidermal necrolysis (extremely rare).
  • Hepatic toxicity: rare liver enzyme elevation reported with extensive use.

Precautions & Warnings

  • Ciclopirox should be used with attention to specific safety considerations.
  • Pregnancy: safety not established; use only if clearly needed.
  • Breastfeeding: unknown safety profile; exercise caution.
  • Renal impairment: no dosage adjustment required, but monitor renal function.
  • Use only on intact nails and surrounding skin; avoid application to broken skin.
  • Avoid extensive use on large skin areas to reduce irritation risk.
  • Store at room temperature: keep in original packaging, protect from moisture and direct light.

Avoid Interactions

Ciclopirox may interact with other medications, requiring attention to potential effects.

Major Interactions (Avoid)

  • Concurrent topical antifungals: may increase local irritation.
  • Systemic antifungal agents (e.g., itraconazole): additive toxicity risk.

Moderate Interactions (Monitor Closely)

  • Co‑administration with corticosteroid creams: may mask infection signs.
  • Use with photosensitizing agents: heightened sun sensitivity.
  • Interaction with other chelating agents: possible reduction in antifungal efficacy.

Frequently Asked Questions

Kitonail contains ciclopirox and is indicated for the treatment of onychomycosis, a fungal infection of the nail, as well as dermatophytosis affecting the skin. It is applied topically to the affected nail or skin area to eradicate the fungal pathogen.

Ciclopirox acts by chelating polyvalent cations, which interferes with fungal sterol synthesis. This disruption impairs membrane transport and essential cellular functions, ultimately inhibiting fungal growth and leading to the clearance of the infection at the site of application.

The dosing regimen for Kitonail is determined by the prescribing healthcare professional based on the severity and location of the infection. The prescriber will specify the amount to apply, frequency, and duration of treatment.

Safety data for ciclopirox in pregnancy and lactation are limited. It should be used only if the potential benefit justifies the potential risk to the fetus or infant, and only under the guidance of a qualified healthcare provider.

To request Kitonail, submit an enquiry on the product page at gnhindia.com, indicating the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and necessary import documentation.

Compared with oral antifungals, Kitonail offers a topical option that avoids systemic exposure and related side effects. While oral agents may provide faster systemic clearance, ciclopirox nail lacquer delivers high local concentrations directly to the infected nail, which can be advantageous for localized infections.

Kitonail should be stored at room temperature, below 25 °C, in its original container. Keep the product away from moisture, direct sunlight, and excessive heat to maintain its stability and efficacy.

Kitonail is applied topically to the affected nail or skin area. The prescriber will advise the specific amount to use, typically a thin layer, and the frequency (often once daily). The nail surface should be clean and dry before application.

Serious risks, though rare, include severe allergic reactions such as allergic contact dermatitis, systemic hypersensitivity, and, in extremely rare cases, severe skin reactions like Stevens‑Johnson syndrome. Patients should discontinue use and seek medical attention if they experience widespread rash, swelling, or systemic symptoms.

Kitonail should not be used by individuals with known hypersensitivity to ciclopirox or any component of the formulation. It is also contraindicated on broken skin or extensive skin lesions, and caution is advised for pregnant or breastfeeding women unless deemed necessary by a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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