Product image of Kivenul (Ibuprofen, Paracetamol) supplied by GNH India

Kivenul

Active Ingredient:
Ibuprofen, Paracetamol
Origin:
EU

Kivenul (Ibuprofen, Paracetamol)

Ibuprofen and Paracetamol, the active ingredients in Kivenul, are a nonsteroidal anti‑inflammatory drug (NSAID) and an analgesic presented as an oral tablet for oral use. It provides pain relief, reduces fever and alleviates inflammation in adults and children as directed by a healthcare professional.

GNH India supplies Kivenul as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Sandoz Pharmaceuticals D.D.

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Indications & Clinical Uses

Kivenul combines ibuprofen and paracetamol to address common pain‑related and febrile conditions.

  • Mild to moderate pain: delivers effective analgesia for headaches, musculoskeletal aches, and dental discomfort.
  • Fever: lowers elevated body temperature in acute infections or inflammatory states.
  • Inflammation: reduces swelling and discomfort associated with minor injuries or inflammatory disorders.

How It Works

  • Ibuprofen inhibits cyclooxygenase (COX‑1 and COX‑2) enzymes, decreasing peripheral prostaglandin synthesis and thereby reducing inflammation and pain. Paracetamol acts centrally to inhibit prostaglandin production within the CNS, providing antipyretic and analgesic effects. The combined action results in synergistic relief of pain, fever, and inflammation without significant peripheral anti‑platelet activity.

Side Effects

Common Side Effects

  • Nausea or upset stomach.
  • Dyspepsia or heartburn.
  • Headache.
  • Dizziness.
  • Mild skin rash.
  • Elevated liver enzymes.

Serious or Rare Side Effects

  • Gastrointestinal bleeding or ulcer perforation.
  • Severe skin reactions such as Stevens‑Johnson syndrome.
  • Hepatic failure or severe liver injury.
  • Acute renal impairment.
  • Anaphylactic shock.
  • Cardiovascular events such as myocardial infarction.

Precautions & Warnings

Kivenul should be used with caution in the following situations:

  • Renal impairment: assess kidney function before use.
  • Active peptic ulcer disease: avoid due to risk of GI bleeding.
  • Concomitant anticoagulant therapy: monitor for increased bleeding.
  • Alcohol consumption: limit intake to reduce liver stress.
  • Liver disease: monitor hepatic function regularly.
  • Store at ambient temperature: keep in the original pack, protect from moisture and direct sunlight.

Avoid Interactions

Kivenul may interact with several medications:

Major Interactions (Avoid)

  • Warfarin or other anticoagulants: increased risk of bleeding.
  • Other NSAIDs or corticosteroids: heightened gastrointestinal toxicity.
  • Lithium or methotrexate: elevated plasma concentrations and toxicity.

Moderate Interactions (Monitor Closely)

  • Antihypertensive agents (e.g., ACE inhibitors): possible reduction in blood pressure control.
  • Diuretics: potential for reduced renal perfusion.
  • Selective serotonin reuptake inhibitors (SSRIs): modest increase in bleeding risk.

Frequently Asked Questions

Kivenul is a combination of ibuprofen and paracetamol indicated for the relief of mild to moderate pain, reduction of fever, and alleviation of inflammation associated with conditions such as headaches, musculoskeletal aches, dental pain, and minor injuries.

Ibuprofen blocks cyclooxygenase enzymes, lowering peripheral prostaglandin production, which reduces pain and inflammation. Paracetamol acts centrally to inhibit prostaglandin synthesis in the brain, providing antipyretic and analgesic effects. Together they offer synergistic symptom control.

The appropriate dose of Kivenul is determined by a qualified prescriber based on the patient’s age, weight, clinical condition, and response to therapy. Patients should follow the specific dosing instructions provided by their healthcare professional.

Safety of Kivenul in pregnancy or lactation has not been fully established. Healthcare providers should evaluate the risk‑benefit profile for each individual, and use the medication only if clearly needed and prescribed by a qualified professional.

To request Kivenul, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, confirming trade or institutional credentials before providing pricing, availability, shipping details, and necessary import documentation.

Kivenul combines an NSAID (ibuprofen) with a centrally acting analgesic (paracetamol), offering broader pain and fever control than either agent alone. Compared with single‑ingredient products, it may provide enhanced efficacy at lower individual doses, but the safety profile must be considered.

Kivenul should be stored at ambient temperature, below 25 °C, in its original packaging to protect from moisture and light. Keep the product out of reach of children and avoid storing in humid or excessively hot environments.

Kivenul is taken orally, usually with a full glass of water. It can be taken with or without food, but taking it with food may reduce gastrointestinal discomfort. Follow the prescriber’s instructions regarding timing and frequency.

Serious risks include gastrointestinal bleeding or ulcer perforation, severe skin reactions such as Stevens‑Johnson syndrome, hepatic injury, acute renal impairment, and anaphylaxis. Patients should seek immediate medical attention if they experience signs of these conditions.

Kivenul should be avoided by individuals with known hypersensitivity to ibuprofen, paracetamol, or any excipients, those with active peptic ulcer disease, severe liver or kidney dysfunction, uncontrolled hypertension, and patients on anticoagulant therapy unless specifically advised by a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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