Product image of Kivizidiale (Timolol, Travoprost) supplied by GNH India

Kivizidiale

Active Ingredient:
Timolol, Travoprost
Origin:
EU

Kivizidiale (Timolol, Travoprost)

Timolol and Travoprost, the active ingredients in Kivizidiale, are a beta‑blocker and prostaglandin analog presented as an ophthalmic solution for ocular use. It lowers intra‑ocular pressure in patients with open‑angle glaucoma or ocular hypertension.
GNH India supplies Kivizidiale as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Bausch + Lomb Ireland Limited

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Indications & Clinical Uses

  • Kivizidiale is indicated for conditions affecting intra‑ocular pressure within the glaucoma and ocular hypertension disease family.
  • Open‑angle glaucoma: reduces intra‑ocular pressure to slow disease progression.
  • Ocular hypertension: lowers eye pressure to prevent conversion to glaucoma.
  • Adjunctive therapy in patients requiring multiple mechanisms: provides combined beta‑blocker and prostaglandin effects for enhanced IOP control.

How It Works

  • Timolol, a non‑selective beta‑adrenergic blocker, decreases aqueous humor production by inhibiting beta receptors in the ciliary body. Travoprost, a prostaglandin F2α analogue, increases uveoscleral outflow of aqueous humor. The complementary actions of reduced production and enhanced outflow result in a net lowering of intra‑ocular pressure.

Side Effects

Common Side Effects

  • Eye irritation or burning sensation
  • Blurred vision shortly after instillation
  • Redness of the eye
  • Dry eye or foreign‑body sensation
  • Mild headache
  • Transient ocular discomfort

Serious or Rare Side Effects

  • Severe allergic reaction (e.g., angio‑edema)
  • Worsening of glaucoma or uncontrolled IOP
  • Significant bradycardia or hypotension
  • Bronchospasm in susceptible individuals
  • Persistent eye pain or vision loss
  • Corneal ulceration or infection

Precautions & Warnings

  • Kivizidiale requires careful patient assessment and monitoring.
  • Assess cardiovascular status: timolol may affect heart rate and blood pressure.
  • Screen for respiratory disease: avoid in patients with asthma or COPD.
  • Monitor intra‑ocular pressure: ensure adequate pressure reduction after initiation.
  • Avoid use in patients with severe ocular inflammation or infection.
  • Store at room temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Kivizidiale may interact with other systemic or ocular agents.

Major Interactions (Avoid)

  • Concurrent non‑selective beta‑blockers: risk of additive systemic beta‑blockade.
  • Other ocular beta‑blocker drops: may cause excessive IOP lowering.

Moderate Interactions (Monitor Closely)

  • Systemic carbonic anhydrase inhibitors: potential additive IOP‑lowering effect.
  • Anticholinergic eye drops: may influence ocular surface tolerance.
  • Topical NSAIDs: increased risk of corneal irritation.
  • Systemic steroids: possible alteration of IOP response.

Frequently Asked Questions

Kivizidiale is an ophthalmic solution that combines timolol and travoprost to lower intra‑ocular pressure. It is prescribed for patients with open‑angle glaucoma or ocular hypertension to help prevent disease progression and protect vision.

Timolol blocks beta‑adrenergic receptors in the eye, reducing the production of aqueous humor. Travoprost mimics prostaglandin F2α, increasing the outflow of fluid through the uveoscleral pathway. Together they provide a dual mechanism that effectively lowers eye pressure.

The dosing regimen for Kivizidiale is determined by the prescribing clinician based on the patient’s condition and response. Typically, one drop is instilled in the affected eye(s) once daily, but exact instructions must come from a qualified eye‑care professional.

Safety data for Kivizidiale in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any potential risk to the fetus or infant, and the decision must be made by the prescribing physician.

To order Kivizidiale, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Kivizidiale offers a fixed‑dose combination of a beta‑blocker and a prostaglandin analogue, providing two mechanisms of action in a single bottle. This can simplify treatment compared with using separate timolol and travoprost drops, potentially improving adherence while delivering comparable IOP‑lowering efficacy.

Kivizidiale should be stored at room temperature, below 25 °C, in its original container. Keep the bottle tightly closed, protect it from light and moisture, and discard any solution that appears discolored or contains particles.

Kivizidiale is applied as an eye drop. The patient should wash their hands, tilt the head back, pull down the lower eyelid, and place a single drop into the conjunctival sac of the affected eye(s). Close the eye gently for a few seconds and avoid blinking excessively.

Serious risks include severe allergic reactions, significant drops in heart rate or blood pressure, bronchospasm in patients with respiratory disease, and worsening of glaucoma if IOP is not adequately controlled. Patients should seek immediate medical attention if they experience any of these symptoms.

Kivizidiale is contraindicated in patients with known hypersensitivity to timolol, travoprost, or any excipients, as well as those with severe bronchial asthma, chronic obstructive pulmonary disease, or certain cardiac conduction disorders. It should also be avoided in eyes with active inflammation or infection.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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